Patents by Inventor Pilar Gallego
Pilar Gallego has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8076337Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.Type: GrantFiled: April 6, 2010Date of Patent: December 13, 2011Assignee: Pharma Mar, S.A.Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
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Patent number: 7947671Abstract: Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.Type: GrantFiled: April 12, 2010Date of Patent: May 24, 2011Assignee: Pharma Mar, S.A.Inventors: Valentin Martinez Barrasa, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Roberto Menchaca, Natividad Rodriguez, Alberto Rodriguez
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Patent number: 7919493Abstract: This invention relates to antitumoral ecteinascidin derivatives that contain a fused ecteinascidin five ring system with a 1,4-bridge having the structure of formula (VIa) or (VIb) as described herein and compounds in which the —NH2 or —OH of the 1,4-bridge is derivatized, and related pharmaceutical compositions and methods. Such ecteinascidin derivatives include, but are not limited to, those compounds having formula (XVIIb): in which R1 and R4 together form a group of formula (VIa) or (VIb) as described herein, and R5, R7, R8, R14a, R14b, R15, and R21 are as defined herein.Type: GrantFiled: April 10, 2007Date of Patent: April 5, 2011Assignee: Pharma Mar, S.A.Inventors: Maria Flores, Andres Francesh, Pilar Gallego, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares
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Patent number: 7795260Abstract: Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.Type: GrantFiled: November 19, 2008Date of Patent: September 14, 2010Assignee: Pharma Mar, S.A.Inventors: Valentin Martinez Barrasa, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Roberto Menchaca, Natividad Rodriguez, Alberto Rodriguez
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Publication number: 20100216987Abstract: Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.Type: ApplicationFiled: April 12, 2010Publication date: August 26, 2010Inventors: Valentin Martinez Barrasa, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Roberto Menchaca, Natividad Rodriguez, Alberto Rodriguez
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Publication number: 20100197695Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula Ia.: wherein the substituent groups take various permitted meanings.Type: ApplicationFiled: April 6, 2010Publication date: August 5, 2010Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
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Patent number: 7767659Abstract: Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.Type: GrantFiled: February 4, 2003Date of Patent: August 3, 2010Assignee: Pharma Mar, S.A.Inventors: Valentin Martinez Barrasa, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Roberto Menchaca, Natividad Rodriguez, Alberto Rodriguez
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Patent number: 7763615Abstract: Derivatives of ecteinascidin 736 of general formula (I) wherein the groups R1, R2, R3, R4 and R5 are each independently selected from the group consisting of H, OH, OR?, SH, SR?, SOR?, SO2R?, C(?O)R?, C(?O)OR?, NO2, NH2, NHR?, N(R?)2, NHC(O)R?, CN, halogen, ?O, substituted or unsubstituted C1-C25 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic; wherein X is independently selected of OR?, CN, (?O), or H; wherein each of the R? groups is independently selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, ?O, C(?O)H, C(?O)CH3, CO2H, substituted or unsubstituted C1-C25 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl; wherein m is 0, 1 or 2; and wherein n is 0, 1, 2, 3, or 4, and their use as antitumoral agent.Type: GrantFiled: August 6, 2002Date of Patent: July 27, 2010Assignee: Pharma Mar, S.A.Inventors: Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Valentin Martinez
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Patent number: 7759345Abstract: Derivatives of Et-743 or Et-770 or Et-729 are provided. The derivatives are of the general formula (Ia) wherein the substituent groups take various permitted meanings.Type: GrantFiled: July 17, 2002Date of Patent: July 20, 2010Assignee: Pharma Mar, S.A.Inventors: Valentin Martinez, Maria Flores, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares
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Patent number: 7678765Abstract: The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.Type: GrantFiled: April 20, 2007Date of Patent: March 16, 2010Assignee: Pharma Mar, S.A.Inventors: Ignacio Rodriguez, Concepción Polanco, Felix Cuevas, Paloma Mandez, Carmen Cuevas, Pilar Gallego, Simon Munt, Ignacio Manzanares
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Publication number: 20090163507Abstract: Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.Type: ApplicationFiled: November 19, 2008Publication date: June 25, 2009Applicant: PHARMA MAR, S.A.Inventors: Valentin Martinez Barrasa, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Roberto Menchaca, Natividad Rodriguez, Alberto Rodriguez
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Patent number: 7524956Abstract: Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from —H, —OH or —OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both —H ozone is —H and the other is —OH, —OCH3 or —OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from —H or —OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.Type: GrantFiled: July 9, 2007Date of Patent: April 28, 2009Assignee: Pharma Mar, S.A.Inventors: Carmen Cuevas, Marta Perez, Andres Francesch, Carolina Fernandez, Jose Luis Chicharro, Pilar Gallego, Maria Zarzuelo, Fernando de Calle, Ignacio Manzanares
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Patent number: 7420051Abstract: Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxyl, di-6,8-en-5-one fused ring compound. After formation of the 1,4 brige, C-18 protection is removed before spiroamine introduction.Type: GrantFiled: October 11, 2005Date of Patent: September 2, 2008Assignee: Pharma Mar, S.A.Inventors: Andrés Francesch, Carolina Fernández, José Luis Chicharro, Pilar Gallego, Maria Zarzuelo, Ignacio Manzanares, Marta Perez, Carmen Cuevas, María Jes{dot over (u)}s Martin, Simon Munt
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Publication number: 20080146580Abstract: This invention relates to antitumoral ecteinascidin derivatives.Type: ApplicationFiled: April 10, 2007Publication date: June 19, 2008Applicant: PHARMAMARInventors: Maria Flores, Andres Francesh, Pilar Gallego, Jose Luis Chicharro, Maria Zarzuelo, Carolina Fernandez, Ignacio Manzanares
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Patent number: 7348310Abstract: The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.Type: GrantFiled: July 2, 2001Date of Patent: March 25, 2008Assignee: Pharma Mar, S.A.Inventors: Ignacio Rodriguez, Concepción Polanco, Felix Cuevas, Paloma Mendez, Carmen Cuevas, Pilar Gallego, Simon Munt, Ignacio Manzanares
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Publication number: 20080045713Abstract: Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an aryloxymethylene group; R5 and R8 are independently chosen from —H, —OH or —OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both —H ozone is —H and the other is —OH, —OCH3 or —OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from —H or —OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.Type: ApplicationFiled: July 9, 2007Publication date: February 21, 2008Applicant: Pharma Mar, S.A.Inventors: Carmen Cuevas, Marta Perez, Andres Francesch, Carolina Fernandez, Jose Chicharro, Pilar Gallego, Maria Zarzuelo, Fernando Calle, Ignacio Manzanares
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Publication number: 20080009435Abstract: The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.Type: ApplicationFiled: April 20, 2007Publication date: January 10, 2008Inventors: Ignacio Rodriguez, Concepcion Polanco, Felix Cuevas, Paloma Mendez, Carmen Cuevas, Pilar Gallego, Simon Munt, Ignacio Manzanares
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Patent number: 7241892Abstract: Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically: R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from —H, —OH or —OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both —H ozone is —H and the other is —OH, —OCH3 or —OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from —H or —OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.Type: GrantFiled: May 15, 2000Date of Patent: July 10, 2007Assignee: Pharma Mar, S.A.Inventors: Carmen Cuevas, Marta Perez, Andres Francesch, Carolina Fernandez, Jose Luis Chicharro, Pilar Gallego, Maria Zarzuelo, Fernando de la Calle, Ignacio Manzanares
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Patent number: 7202361Abstract: This invention relates to compounds of the formula: wherein: the substituent groups defined by R1, R2 are each independently selected of H, C(?O)R?, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl; each of the R? groups is independently selected from the group consisting of H; OH; NO2; NH2; SH; CN; halogen; ?O; C(?O)H; C(?O)CH3; CO2H; or C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl, each of which, independently, may be substituted with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, nitro, azido; alkanoyl, carboxamido, alkyl, alkenyl, alkynyl, aryloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aminoalkyl, carbocylic aryl having 6 or more carbons, and aralkyl; X2 is OX1 or N(X1)2 wherein each X1 is independently H, C(?O)R? where R? is as defined, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, aryl, alkoxy, heterocyclyl, or two X1 groups together form a cyclic substituent on the nitrogen atom, or X1 is SO2CH3 when X2 is OX1, or N(X1)2 is NHCOalkType: GrantFiled: April 12, 2001Date of Patent: April 10, 2007Assignee: PharmaMarInventors: Maria Flores, Andrés Francesch, Pilar Gallego, José Luis Chicharro, Maria Zarzuelo, Carolina Fernández, Ignacio Manzanares
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Patent number: 7138547Abstract: New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, CN, halogen, C(?O)H, C(?O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, or two groups X may together form ?O; Y is NR1, OR1, PR1, SR1, or halogen, wherein the number of substituents R1 is selected to suit the valency and each R1 is independently selected of H, OH, C(?O)R?, P(?O)R?R?, substituted or unsubstituted C1–C18 alkyl, substituted or unsubstituted C2–C18 alkenyl, substituted or unsubstituted C2–C18 alkynyl, substituted or unsubstituted aryl, and wherein the dotted line indicates an optional double bond; each Z is the same different, and represents H, OH, OR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, NHC(O)R?, CN, halogen, C(?OType: GrantFiled: June 6, 2001Date of Patent: November 21, 2006Assignee: Pharma Mar, S.A.Inventors: Jose Luis Aceña, Javier Adrio, Carmen Cuevas, Pilar Gallego, Ignacio Manzanares, Simon Munt, Ignacio Rodriguez