Patents by Inventor Pilarin E.L. Nichols

Pilarin E.L. Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides as solubilizing excipients for transforming growth factor beta proteins
    Patent number: 7241740
    Abstract: The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: July 10, 2007
    Assignee: Wyeth
    Inventors: Pilarin E.L. Nichols, Bernardo Perez-Ramirez
  • Peptides as solubilizing excipients for transforming growth factor beta proteins
    Publication number: 20040102378
    Abstract: The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
    Type: Application
    Filed: August 12, 2003
    Publication date: May 27, 2004
    Inventors: Pilarin E.L. Nichols, Bernardo Perez-Ramirez