Patents by Inventor Pilarin Nichols

Pilarin Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDES AS SOLUBILIZING EXCIPIENTS FOR TRANSFORMING GROWTH FACTOR BETA PROTEINS
    Publication number: 20070244050
    Abstract: The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
    Type: Application
    Filed: June 4, 2007
    Publication date: October 18, 2007
    Inventors: Pilarin Nichols, Bernardo Perez-Ramirez
  • Protein formulations with reduced viscosity and uses thereof
    Publication number: 20070172479
    Abstract: Protein formulations and methods for reducing the viscosity of a protein formulation are provided. The method for reducing the viscosity of a protein formulation comprises adding a viscosity reducing agent, such as calcium chloride or magnesium chloride to the protein formulation.
    Type: Application
    Filed: December 21, 2006
    Publication date: July 26, 2007
    Applicant: Wyeth
    Inventors: Nicholas Warne, Pilarin Nichols, Paulo Loueiro