Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: Various embodiments of the present disclosure are directed towards a method for opening a source line in a memory device. An erase gate line (EGL) and the source line are formed elongated in parallel. The source line underlies the EGL and is separated from the EGL by a dielectric layer. A first etch is performed to form a first opening through the EGL and stops on the dielectric layer. A second etch is performed to thin the dielectric layer at the first opening, wherein the first and second etches are performed with a common mask in place. A silicide process is performed to form a silicide layer on the source line at the first opening, wherein the silicide process comprises a third etch with a second mask in place and extends the first opening through the dielectric layer. A via is formed extending through the EGL to the silicide layer.

Abstract: An image sensor module includes a sensing surface, a filter element and a first anti-reflective microstructure, wherein the filter element faces towards the sensing surface, and the first anti-reflective microstructure is disposed on the sensing surface. The filter element includes a substrate, an optical deposition layer structure and an optical coating layer, wherein the optical deposition layer structure is disposed on a side of the substrate away from the sensing surface, and the optical coating layer and the optical deposition layer structure are correspondingly disposed on a side of the substrate facing towards the sensing surface. The optical deposition layer structure is multilayer. An air layer is formed between the first anti-reflective microstructure and the filter element, and the first anti-reflective microstructure and the air layer partially overlap at a direction vertical to the sensing surface.

Abstract: A light guide assembly includes a housing element, at least one light guide element, and at least one light-shielding element. The housing element includes an outer surface and an inner surface. The light guide element is configured for a light to pass therethrough. The light guide element includes a light entrance surface, at least one light exit surface, and at least one wall surface. The wall surface surrounds and is connected to an edge of the light exit surface and extends toward the light entrance surface. The light exit surface is in contact with the inner surface. The at least one light-shielding element surrounds the at least one wall surface and is in contact with the inner surface.

Abstract: A titanium precursor is used to selectively form a titanium silicide (TiSix) layer in a semiconductor device. A plasma-based deposition operation is performed in which the titanium precursor is provided into an opening, and a reactant gas and a plasma are used to cause silicon to diffuse to a top surface of a transistor structure. The diffusion of silicon results in the formation of a silicon-rich surface of the transistor structure, which increases the selectivity of the titanium silicide formation relative to other materials of the semiconductor device. The titanium precursor reacts with the silicon-rich surface to form the titanium silicide layer. The selective titanium silicide layer formation results in the formation of a titanium silicon nitride (TiSixNy) on the sidewalls in the opening, which enables a conductive structure such as a metal source/drain contact to be formed in the opening without the addition of another barrier layer.

Abstract: A shower head structure and a plasma processing apparatus are provided. The shower head structure includes a plate body with a first zone and a second zone on a first surface. A plurality of first through holes are in the first zone, each of the first through holes having a diameter uniform with others of the first through holes. A plurality of second through holes are in the second zone. The first zone is in connection with the second zone, and the diameter of each of the first through holes is greater than a diameter of each of the second through holes. A plasma processing apparatus includes the shower head structure is also provided.

Abstract: An optical member driving mechanism for connecting an optical member is provided, including a fixed portion and a first adhesive member. The fixed portion includes a first member and a second member, wherein the first member is fixedly connected to the second member via the first adhesive member.

Abstract: A spherical multi-axis optical fiber sensing device is formed by a three-axis optical interference sensor composed of a multi-level opto-mechanical integrated unit kit. The opto-mechanical integrated unit kit is composed of three fiber rings, which are respectively a large fiber ring, a medium fiber ring and a small fiber ring. The multi-level opto-mechanical integrated unit kit is combined with the use of the mechanism component technology that can be freely rotated and positioned to achieve the functional purpose of establishing a three-axis orthogonal optical fiber sensing unit in a single sphere volume.

Abstract: The present disclosure provides a Lipid-Based Lipid Agent being a compound of Formula (I), (II), (III), or (IV): or pharmaceutically acceptable salts thereof, and related conjugates. The present disclosure also relates to uses of the Lipid-Based Lipid Agents and conjugates, e.g., in delivering nucleic acid and/or treating or preventing diseases.

Abstract: Disclosed herein is a sampling face mask. The sampling mask includes a mask body having a front side, a bottom, and one or more clamping blocks disposed on the bottom; a removable cartridge comprising a cartridge body having a chamber for housing the substances exhaled from the nose of the subject, and a door disposed above the chamber for opening or closing the chamber, and a driving means for driving the door to move laterally or vertically with respective to the cartridge body; wherein, the one or more clamping blocks can hold the door in place thereby keeping the door from closing; and when the one or more clamping blocks does not hold the door in place, the door is driven close via the driving means thereby closing the chamber and allowing the removable cartridge to be separated from the mask body.

Abstract: The invention provides non-opioid pain therapeutic compositions that include an antisense oligonucleotide (ASO) complementary to an identified target on a NaV channel mRNA. The ASO hybridizes to its target RNA and forms a duplex that recruits RNase H to degrade the RNA, thereby downregulating NaV channel synthesis, which inhibits the neuron's ability to contribute to the perception of pain. The ASO targets one of the specific identified targets, and may be provided as a gapmer that includes a central DNA segment flanked by modified RNA wings. When the composition is delivered to dorsal root ganglion (DRG) neurons in vitro, the DRG neurons exhibit a dose-dependent knockdown of NaV1.7, NaV1.8, or NaV1.9.

Abstract: An electronic device includes a switch element and a voltage clamping element. The switch element includes a first end, a second end, and a control end. The switch element conducts the first end with the second end of the switch element according to a first voltage on the control end. The voltage clamping element includes a first end, a second end, and a control end. The control end of the voltage clamping element is electrically connected to the second end of the switch element and a ground voltage, and the second end of the voltage clamping element is electrically connected to the control end of the switch element. The voltage clamping element clamps the first voltage to a preset voltage based on the voltage difference between the first voltage and the ground voltage.

Abstract: An electronic device includes an input end, a power amplifier, a voltage dividing circuit, and a driving circuit. The input end receives an input signal. The power amplifier is electrically connected between the power voltage and the ground voltage and includes a first control end. The voltage dividing circuit divides the input signal and outputs a divided voltage signal. The driving circuit includes a second control end. The driving circuit is electrically connected to the voltage dividing circuit through the second control end. The driving circuit is electrically connected to the first control end of the power amplifier. The driving circuit is electrically connected to the input end through a bus to receive the input signal. The driving circuit outputs the input signal to the power amplifier according to the voltage of the divided voltage signal to drive the power amplifier.

Abstract: The invention provides non-opioid pain therapeutic compositions that include an antisense oligonucleotide (ASO) complementary to an identified target on a NaV channel mRNA. The ASO hybridizes to its target RNA and forms a duplex that recruits RNase H to degrade the RNA, thereby downregulating NaV channel synthesis, which inhibits the neuron's ability to contribute to the perception of pain. The ASO targets one of the specific identified targets, and may be provided as a gapmer that includes a central DNA segment flanked by modified RNA wings. When the composition is delivered to dorsal root ganglion (DRG) neurons in vitro the DRG neurons exhibit a dose-dependent knockdown of NaV 1.7 NaV 1.8 or NaV 1.9.

Abstract: A shower head structure and a plasma processing apparatus are provided. The shower head structure includes a plate body with a first zone and a second zone on a first surface. A plurality of first through holes are in the first zone, each of the first through holes having a diameter uniform with others of the first through holes. A plurality of second through holes are in the second zone. The first zone is in connection with the second zone, and the diameter of each of the first through holes is greater than a diameter of each of the second through holes. A plasma processing apparatus includes the shower head structure is also provided.

Abstract: A shower head structure and a plasma processing apparatus are provided. The shower head structure includes a plate body with a first zone and a second zone on a first surface. A plurality of first through holes are in the first zone, each of the first through holes having a diameter uniform with others of the first through holes. A plurality of second through holes are in the second zone. The first zone is in connection with the second zone, and the diameter of each of the first through holes is greater than a diameter of each of the second through holes. A plasma processing apparatus includes the shower head structure is also provided.

Abstract: An electronic paper display and a driving method thereof are provided. The electronic paper display includes an electronic paper display panel, a touch panel and a processing circuit. The touch panel outputs a first touch coordinate of a current touch and a second touch coordinate of a next touch. The processing circuit executes a filter module and a line drawing module. The filter module outputs a first measured position data and a first predicted position data to the line drawing module. The line drawing module drives the electronic paper display panel to display a first predicted track. The filter module outputs a second measured position data to the line drawing module. The line drawing module determines whether a second track display coordinate corresponding to the second measured position data is equal to the first predicted display coordinate to correct the first predicted track.

Abstract: A plasma ashing method is provided. The plasma ashing method includes analyzing the process status of each of a number of semiconductor substrate models undergoing a tested plasma ash process by a residue gas analyzer. The tested plasma ash processes for the semiconductor substrate models utilize a plurality of tested recipes. The plasma ashing method further includes selecting one of the tested recipes as a process recipe for a plasma ash process.

Abstract: The invention introduces a method for producing solid state disk (SSD) devices, performed by a processing unit of a production host, to include steps of: loading a port-mapping configuration table including location information regarding each port connected to the production host; comparing location information in a hardware description file with the location information in the port-mapping configuration table to determine which ports that SSD devices are connected to; displaying a graphical user interface (GUI) on a displayer to indicate which ports are connected by SSD devices; and when an SSD device connected to one port that fails to activate, updating the GUI to display information indicating that an SSD device connected to the corresponding port that fails to activate.

Abstract: An electronic paper display and a driving method thereof are provided. The electronic paper display includes an electronic paper display panel, a touch panel and a processing circuit. The touch panel outputs a first touch coordinate of a current touch and a second touch coordinate of a next touch. The processing circuit executes a filter module and a line drawing module. The filter module outputs a first measured position data and a first predicted position data to the line drawing module. The line drawing module drives the electronic paper display panel to display a first predicted track. The filter module outputs a second measured position data to the line drawing module. The line drawing module determines whether a second track display coordinate corresponding to the second measured position data is equal to the first predicted display coordinate to correct the first predicted track.