Patents by Inventor Pinchas Akiva

Pinchas Akiva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR AND USE THEREOF
    Publication number: 20110212051
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: February 28, 2011
    Publication date: September 1, 2011
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Polynucleotides encoding polypeptides and methods using same
    Patent number: 7939634
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 10, 2011
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • METHODS AND SYSTEMS FOR ANNOTATING BIOMOLECULAR SEQUENCES
    Publication number: 20110091454
    Abstract: Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
    Type: Application
    Filed: February 8, 2010
    Publication date: April 21, 2011
    Inventors: Alex Diber, Sarah Pollock, Zurit Levine, Sergey Nemzer, Vladimir Grebinskiy, Brian Meloon, Andrew Olson, Avi Rosenberg, Ami Haviv, Shaul Zevin, Tomer Zekharia, Zipi Shaked, Moshe Olshansky, Ariel Farkash, Eyal Privman, Amit Novik, Naomi Keren, Gad S. Cojocaru, Pinchas Akiva, Yossi Cohen, Ronen Shemesh, Osnat Sella-Tavor, Liat Mintz, Hanqing Xie, Dvir Dahary, Erez Levanon, Shiri Freilich, Nili Beck, Wei-Yong Zhu, Alon Wasserman, Chen Chermesh, Idit Azar, Rotem Sorek, Jeanne Bernstein
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer
    Patent number: 7906635
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 15, 2011
    Assignee: Compugen Ltd.
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
    Patent number: 7842459
    Abstract: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: November 30, 2010
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Sarah Pollock, Ronen Shemesh, Rotem Sorek, Zurit Levine, Zipi Shaqed, Amir Toporik, Gad S. Cojocaru, Dvir Dahary, Guy Kol, Pinchas Akiva, Amit Novik, Sergey Nemzer, Alexander Diber, Maxim Shklar, Osnat Sella-Tavor, Lily Bazak, Ariel Farkash, Yossi Cohen
  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of use Thereof for Diagnosis of Ovarian Cancer
    Publication number: 20100124786
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 20, 2010
    Applicant: Compugen LTD
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
    Publication number: 20100120022
    Abstract: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
    Type: Application
    Filed: January 27, 2005
    Publication date: May 13, 2010
    Inventors: Michal Ayalon-Soffer, Sarah Pollock, Ronen Shemesh, Rotem Sorek, Zurit Levine, Zipi Shaqed, Amir Toporik, Gad S. Cojocaru, Dvir Dahary, Guy Kol, Pinchas Akiva, Amit Novik, Sergey Nemzer, Alexander Diber, Maxim Shklar, Osnat Sella-Tavor, Lily Bazak, Ariel Farkash, Yossi Cohen
  • Novel polynucleotides encoding polypeptides and methods using same
    Publication number: 20100075891
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: January 27, 2005
    Publication date: March 25, 2010
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Lung Cancer
    Publication number: 20100068736
    Abstract: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 18, 2010
    Applicant: Compugen LTD.
    Inventors: Sarah Pollock, Zurit Levine, Amit Novik, Dvir Dahary, Rotem Sorek, Amir Toporik, Shirley Sameah-Greenwald, Osnat Sella-Tavor, Alexander Diber, Gad S. Cojocaru, Michal Ayalon-Soffer, Shira Walach, Pinchas Akiva, Naomi Keren, Ronen Shemesh
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer
    Patent number: 7667001
    Abstract: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 23, 2010
    Assignee: Compugen Ltd.
    Inventors: Sarah Pollock, Zurit Levine, Amit Novik, Dvir Dahary, Rotem Sorek, Amir Toporik, Shirley Sameah-Greenwald, Osnat Sella-Tavor, Alexander Diber, Gad S. Cojocaru, Michal Avalon-Soffer, Shira Walach, Pinchas Akiva, Naomi Keren, Ronen Shemesh
  • NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS OF BREAST CANCER
    Publication number: 20090286957
    Abstract: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 19, 2009
    Applicant: Compugen LTD
    Inventors: Amir Toporik, Dvir Dahary, Rotem Sorek, Sarah Pollock, Zurit Levine, Pinchas Akiva, Alexander Diber, Amit Novik, Osnat Sella-Tavor, Michal Ayalon-Soffer, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Naomi Keren, Maxim Shklar
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer
    Patent number: 7569662
    Abstract: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: August 4, 2009
    Assignee: Compugen Ltd
    Inventors: Sarah Pollock, Zurit Levine, Amit Novik, Dvir Dahary, Rotem Sorek, Amir Toporik, Shirley Sameah-Greenwald, Osnat Sella-Tavor, Alexander Diber, Gad S. Cojocaru, Michal Ayalon-Soffer, Shira Walach, Pinchas Akiva, Naomi Keren, Ronen Shemesh
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer
    Patent number: 7553948
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: June 30, 2009
    Assignee: Compugen Ltd
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer
    Patent number: 7528243
    Abstract: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: May 5, 2009
    Assignee: Compugen Ltd
    Inventors: Amir Toporik, Dvir Dahary, Rotem Sorek, Sarah Pollock, Zurit Levine, Pinchas Akiva, Alexander Diber, Amit Novik, Osnat Sella-Tavor, Michal Ayalon-Soffer, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Naomi Keren, Maxim Shklar
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer
    Publication number: 20090004648
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Application
    Filed: March 6, 2007
    Publication date: January 1, 2009
    Applicant: COMPUGEN LTD.
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer
    Patent number: 7368548
    Abstract: Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 6, 2008
    Assignee: Compugen Ltd.
    Inventors: Dvir Dahary, Sarah Pollock, Zurit Levine, Rotem Sorek, Michal Ayalon-Soffer, Pinchas Akiva, Amir Toporik, Osnat Sella-Tavor, Shirley Sameah-Greenwald
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer
    Publication number: 20080014590
    Abstract: Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
    Type: Application
    Filed: June 19, 2007
    Publication date: January 17, 2008
    Applicant: COMPUGEN LTD.
    Inventors: Dvir Dahary, Sarah Pollock, Zurit Levine, Rotern Sorek, Michal Avalon-Soffer, Pinchas Akiva, Amir Toporik, Osnat Sella-Tavor, Shirley Sameah-Greenwald
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer
    Publication number: 20070259386
    Abstract: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
    Type: Application
    Filed: February 28, 2007
    Publication date: November 8, 2007
    Applicant: COMPUGEN LTD.
    Inventors: Amir Toporik, Dvir Dahary, Rotem Sorek, Sarah Pollock, Zurit Levine, Pinchas Akiva, Alexander Diber, Amit Novik, Osnat Sella-Tayor, Michal Ayalon-Soffer, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Naomi Keren, Maxim Shklar
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer
    Publication number: 20060183131
    Abstract: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
    Type: Application
    Filed: January 27, 2005
    Publication date: August 17, 2006
    Inventors: Amir Toporik, Dvir Dahary, Rotem Sorek, Sarah Pollock, Zurit Levine, Pinchas Akiva, Alexander Diber, Amit Novik, Osnat Sella-Tavor, Michal Ayalon-Soffer, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Naomi Keren, Maxim Shklar
  • Novel calcium channel variants and methods of use thereof
    Publication number: 20060147946
    Abstract: Novel alpha 1 subunit splice variants, including nucleic and amino acid sequences. Methods of use thereof are also described.
    Type: Application
    Filed: January 27, 2005
    Publication date: July 6, 2006
    Inventors: Pinchas Akiva, Alexander Dlber, Sarah Pollock, Zurit Levine, Sergey Nemzer, Vladimir Grebinskiy, Brian Meloon, Andrew Olson, Avi Rosenberg, Ami Haviv, Shaul Zevin, Tomer Zekhari, Zipi Shaged, Moshe Olshansky, Arial Farkash, Eyal Privman, Amit Novik, Naomi Keren, Gad Cojocaru, Yossi Cohen, Ronen Shemesh, Osnat Sella-Tavor, Liat Mintz, Hanquing Xie, Dvir Dahary, Erez Levanon, Shiri Freilich, Nili Beck, Wei-Yong Zhu, Alon Wasserman, Chen Chermesh, Idit Azar, Rotem Sorek, Jeanne Bernstein