Abstract: A method and device for issuing an identity certificate to a blockchain node in a blockchain network includes issuing a first identity certificate to a first terminal. a second identity certificate issuance request that is from the first terminal and that is made by using the first identity certificate is received and a second identity certificate is issued to the first terminal, which forwards the second identity certificate to a second terminal. A third identity certificate issuance request that is from the second terminal and that is made by using the second identity certificate is received and a third identity certificate is issued to the second terminal, which forwards the third identity certificate to a third terminal.

Abstract: This disclosure relates to methods for the treatment of neoplastic disorders by administering Compound 1, or a pharmaceutically acceptably salt thereof, on its own and/or as part of a conjugate or composition, and inducing production of at least one neoantigen.

Abstract: The present disclosure discloses an ankle prosthesis containing zirconium-niobium alloy on oxidation layer and a preparation method thereof, the preparation method comprises: using zirconium-niobium alloy powder as a raw material, conducting a 3D printing for one-piece molding to obtain an intermediate products of the talus part and tibial part, and performing Sinter-HIP, cryogenic cooling and surface oxidation to obtain talus part and tibial part. The talus part is connected with the tibial part in a sliding mode; a bone trabeculae is respectively arranged on the lower surface of the talus body and the outer surfaces of the two first fixations, and on the upper surface of the tibial body and the outer surfaces of the two second fixations as well, so as to improve bone ingrowth.

Abstract: A fan frame includes a central base, a frame wall, and a plurality of static blades radially extending from the central base to the frame wall, each static blade is connected to the central base at a first end and connected to the frame wall at a second end, the central base is provided with a first wire groove, the frame wall is provided with a second wire groove, the first wire groove and the second wire groove are configured for accommodating wires, and the second wire groove has a shape same as the second end of the static blade connected to the frame wall for gathering the wires to shape similar to the static blade. A fan assembly including the fan frame is also disclosed.

Abstract: A full-frequency band high quality speaker with a bar and sound tunnels includes a voice coil, magnet, diaphragm and magnetically conductive structure; the diaphragm is conical, a bridge-style bar is on the surface of at least one side of the diaphragm; the diaphragm includes at least two grooves, each horizontally radial; each groove crosses the bridge-type bar in the horizontal direction and the length direction of the groove is perpendicular to the bridge-type bar; the groove is concave on the surface of the diaphragm to form a sound tunnel. The diaphragm is changed to the current standard vibration mode, and the timbre of treble register is not bright and the timbre of bass register is not sonorous and mellow enough from the perspective of vibration, resonance and phonation. The practice proves that the improved scheme has outstanding substantive characteristics and remarkable technical progress, and has obtained obvious technical results.

Abstract: The present invention relates to a ventilating and blanking device for a coal storage Eurosilo. The ventilating and blanking device includes a top blanking pipe, an axial flow fan and a baffle door, the top blanking pipe including a first pipeline and a second pipeline, an air supply pipe is connected to a side wall of the second pipeline, and the baffle door is connected to a driving mechanism; during blanking, the driving mechanism drives the baffle door so as to make the baffle door close the air supply pipe and the axial flow fan is shut off; and during ventilation, the driving mechanism drives the baffle door so as to make the baffle door close the first pipeline, and the axial flow fan is turned on. Compared with the prior art, the present invention has the advantages of ventilation efficiency, good ventilation effect, etc.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Embodiments of a generative framework comprise cooperative learning of two generative flow models, in which the two models are iteratively updated based on the jointly synthesized examples. In one or more embodiments, the first flow model is a normalizing flow that transforms an initial simple density into a target density by applying a sequence of invertible transformations, and the second flow model is a Langevin flow that runs finite steps of gradient-based MCMC toward an energy-based model. In learning iterations, synthesized examples are generated by using a normalizing flow initialization followed by a short-run Langevin flow revision toward the current energy-based model. Then, the synthesized examples may be treated as fair samples from the energy-based model and the model parameters are updated, while the normalizing flow directly learns from the synthesized examples by maximizing the tractable likelihood. Also provided are both theoretical and empirical justifications for the embodiments.

Abstract: An identity certificate may be issued to a blockchain node. The issuance may include issuing a first identity certificate to a first terminal and receiving a second identity certificate issuance request that is from the first terminal. A second identity certificate may be issued to the first terminal, and a third identity certificate issuance request is received from the second terminal. A third identity certificate is issued to the second terminal, so that the second terminal forwards the third identity certificate to the third terminal.

Abstract: A method for installing a maximum power point tracking (MPPT) controller is provided. The method includes acquiring an occlusion area proportion of a photovoltaic string in a photovoltaic system, optimizing the occlusion area proportion to generate a target occlusion area proportion, determining a target position from the photovoltaic string according to the target occlusion area proportion, and installing the MPPT controller at the target position.

Abstract: A novel dry powder inhaler. By providing a plurality of capsule chambers (1a, 1b, 1c, 1d) arranged in parallel in a capsule dry powder inhalation device, a medicine dispenser containing active components of a composite product or their mixture separately is provided. The dry powder inhaler has a simple structure and is convenient to operate. In addition, the parameters of air inlet channels and an air outlet channel can be adjusted by means of each capsule chamber (1a, 1b, 1c, 1d) according to the properties of powder of a medicine or a combination, so as to provide an appropriate particle distribution for each active component.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: A method, computer system, and computer program product for data monitoring management are provided. A first invalid zero value candidate from a data stream is received. A memory location for the first invalid zero value candidate is received. At a first time an access connection to the memory location is established. At a second time subsequent to the first time the access connection to the memory location is checked. Based on the checking, a determination is made whether the first invalid zero value candidate contains an invalid zero value.

Abstract: This invention relates to inhibition of the complement signaling using an anti-C5 antibody or fusion protein thereof. Specifically, the invention relates to methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody fusion protein thereof.

Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R4 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

Abstract: A Micro LED transfer method, a display panel, and a fabrication method of the display panel are provided. The Micro LED transfer method includes: transferring Micro LEDs of at least two colors from growth substrates thereof to a plurality of first temporary substrates, respectively, where a first temporary substrate includes Micro LEDs of the at least two colors; and transferring the Micro LEDs of the at least two colors located on a same first temporary substrate to at least one array substrate. A same array substrate includes Micro LEDs of the at least two colors, and the Micro LEDs of the at least two colors located on the same array substrate are simultaneously transferred. A distance between adjacent Micro LEDs of a same color on the first temporary substrate is smaller than a distance between adjacent Micro LEDs of the same color on the array substrate.

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

Abstract: The present invention relates to a support device used in weighing coal of a raw coal bunker in a thermal power plant and a weighable raw coal bunker. The support device includes a base, a positioning sleeve, an upper support and a weighing sensor, a sensor groove being provided in the middle of the base, the weighing sensor being arranged in the sensor groove, the positioning sleeve being arranged on the base in a covering mode, a positioning hole being provided in the middle of the positioning sleeve, the upper support being movably inserted in the positioning hole, and a bottom surface of the upper support penetrating the positioning hole to abut against a top surface of the weighing sensor. The raw coal bunker uses the support device. Compared with the prior art, the present invention effectively meets the weighing requirement of the raw coal bunker.