Abstract: An iridium complex for an organic light-emitting device includes the chemical structural formula shown below, where the ring A is selected from C12-C30 polycyclic groups formed by fusing three or more monocyclic groups with each other, and the precondition is that the ring A at least includes the structure of general formula II: R1-R5 are the same or different, and each independently is H, deuterium, halogen, —CF3, CN, amino, substituted or unsubstituted C1-C10 alkoxyl, or substituted or unsubstituted C1-C30 alkyl, hydrogens on the alkyl chain of the C1-C10 alkoxyl and C1-C30 alkyl may each be independently substituted by deuterium, halogen, —CF3 or CN, where the halogen is selected from fluorine, chlorine, bromine or iodine; Rx and Ry are the same or different, and each independently includes saturated aliphatic ring structure. The iridium complex has excellent red-light saturation, luminous efficiency and thermal stability.

Abstract: The present disclosure relates generally to methods for sensitizing PRC2 mutant tumors to immune checkpoint blockade therapy in a subject in need thereof comprising administering to the subject an effective amount of inactivated modified vaccinia virus Ankara (MVA) or MVA ?E3L.

Abstract: The present disclosure provides compositions and methods for assaying the effectiveness of a potential therapeutic agent for treatment of an activated G?Q mutant cancer (e.g., melanoma or angiosarcoma) or an activated G?Q mutant melanocytic malignancy (e.g., Portwine stain or Sturge-Weber syndrome). Also disclosed herein are methods for treating an activated G?Q mutant cancer (e.g., melanoma or angiosarcoma) or an activated G?Q mutant melanocytic malignancy (e.g., Portwine stain or Sturge-Weber syndrome) in a subject in need thereof.

Abstract: Techniques for reallocating a memory pending queue based on stalls are provided. In one aspect, it may be determined at a memory stop of a memory fabric that at least one class of memory access is stalled. It may also be determined at the memory stop of the memory fabric that there is at least one class of memory access that is not stalled. At least a portion of a memory pending queue may be reallocated from the class of memory access that is not stalled to the class of memory access that is stalled.

Abstract: The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.

Abstract: The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.

Abstract: Techniques for reallocating a memory pending queue based on stalls are provided. In one aspect, it may be determined at a memory stop of a memory fabric that at least one class of memory access is stalled. It may also be determined at the memory stop of the memory fabric that there is at least one class of memory access that is not stalled. At least a portion of a memory pending queue may be reallocated from the class of memory access that is not stalled to the class of memory access that is stalled.

Abstract: Techniques for reallocating a memory pending queue based on stalls are provided. In one aspect, it may be determined at a memory stop of a memory fabric that at least one class of memory access is stalled. It may also be determined at the memory stop of the memory fabric that there is at least one class of memory access that is not stalled. At least a portion of a memory pending queue may be reallocated from the class of memory access that is not stalled to the class of memory access that is stalled.

Abstract: The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.