Patents by Inventor Ping-Ching Wu
Ping-Ching Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11967546Abstract: A semiconductor structure includes a first interposer; a second interposer laterally adjacent to the first interposer, where the second interposer is spaced apart from the first interposer; and a first die attached to a first side of the first interposer and attached to a first side of the second interposer, where the first side of the first interposer and the first side of the second interposer face the first die.Type: GrantFiled: July 21, 2022Date of Patent: April 23, 2024Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.Inventors: Shang-Yun Hou, Hsien-Pin Hu, Sao-Ling Chiu, Wen-Hsin Wei, Ping-Kang Huang, Chih-Ta Shen, Szu-Wei Lu, Ying-Ching Shih, Wen-Chih Chiou, Chi-Hsi Wu, Chen-Hua Yu
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Publication number: 20230201129Abstract: Disclosed herein are electrospun fibrous matrix and its production method. The method mainly includes the steps of, mixing a first polymer and a drug to form a first mixture, and sonicating the first mixture until a plurality of microparticles are formed with the drug encapsulated therein; and mixing the plurality of microparticles with a second polymer to form a second mixture, subjecting the second mixture to a wet electrospinning process to form the electrospun fibrous matrix. The thus-produced electrospun fibrous matrix is characterized by having a plurality of first and second fibrils woven together, in which each second fibril has a plurality of drug-encapsulated microparticles independently integrated and disposed along the longitudinal direction of the second fibril. Also encompassed in the present disclosure is a method for treating a wound of a subject. The method includes applying the present electrospun fibrous matrix to the wound of the subject to accelerate wound healing.Type: ApplicationFiled: December 28, 2021Publication date: June 29, 2023Applicant: NATIONAL CHENG KUNG UNIVERSITYInventors: Ping-Ching WU, Cheng-Hsin CHUANG, Po-Heng CHEN, Yu-Yi CHIANG
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Patent number: 11401232Abstract: Disclosed herein are modified chromium-dpoed zinc gallate (ZGC) nanocubes, which are characterized in respectively having a concave surface that is modified with (3-aminopropyl)triethoxysilane (APTES). The modified ZGC nanocubes produce long lasting luminescence (LLL) that lasts for at least 1.5 hours under X-ray or UV excitation. Also disclosed herein are methods for the preparation of the modified ZGC nanocubes; and methods for imaging an area of interest (e.g., cancer) in a live subject using the modified ZGC nanocubes as an imaging agent.Type: GrantFiled: June 19, 2020Date of Patent: August 2, 2022Assignee: NATIONAL CHENG KUNG UNIVERSITYInventors: Chen-Sheng Yeh, Liu-Chun Wang, Zheng-Zhe Chen, Ping-Ching Wu, Chia-Hao Su
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Patent number: 11214840Abstract: Provided herein are aptamers that bind specifically to the surface proteins of periodontal pathogens. Also provided herein are methods for detecting and treating periodontal disease in a subject. The method comprises detecting bacteria associated with periodontal disease by use of the present aptamers to analyze a sample taken from a gum pocket of a tooth of the subject; and treating the periodontal disease of the subject by administering to the gum pocket of the tooth a bactericide or an anti-microbial phototherapy to eradicate the bacteria associated with periodontal disease.Type: GrantFiled: October 7, 2019Date of Patent: January 4, 2022Assignee: NATIONAL CHENG KUNG UNIVERSITYInventors: Ping-Ching Wu, Dar-Bin Shieh, Fong-Yu Cheng, Yuh-Ling Chen
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Publication number: 20210395182Abstract: Disclosed herein are modified chromium-dpoed zinc gallate (ZGC) nanocubes, which are characterized in respectively having a concave surface that is modified with (3-aminopropyl)triethoxysilane (APTES). The modified ZGC nanocubes produce long lasting luminescence (LLL) that lasts for at least 1.5 hours under X-ray or UV excitation. Also disclosed herein are methods for the preparation of the modified ZGC nanocubes; and methods for imaging an area of interest (e.g., cancer) in a live subject using the modified ZGC nanocubes as an imaging agent.Type: ApplicationFiled: June 19, 2020Publication date: December 23, 2021Inventors: Chen-Sheng YEH, Liu-Chun WANG, Zheng-Zhe CHEN, Ping-Ching WU, Chia-Hao SU
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Publication number: 20200172961Abstract: Provided herein are aptamers that bind specifically to the surface proteins of periodontal pathogens. Also provided herein are methods for detecting and treating periodontal disease in a subject. The method comprises detecting bacteria associated with periodontal disease by use of the present aptamers to analyze a sample taken from a gum pocket of a tooth of the subject; and treating the periodontal disease of the subject by administering to the gum pocket of the tooth a bactericide or an anti-microbial phototherapy to eradicate the bacteria associated with periodontal disease.Type: ApplicationFiled: October 7, 2019Publication date: June 4, 2020Applicant: NATIONAL CHENG KUNG UNIVERSITYInventors: Ping-Ching WU, Dar-Bin SHIEH, Fong-Yu CHENG, Yuh-Ling CHEN
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Patent number: 10487331Abstract: Disclosed herein are aptamers that bind specifically to the surface proteins of periodontal pathogens. Disclosed also herein are kits and methods for detecting bacteria associated with periodontal disease by using the present aptamers to analyze a sample taken from the oral cavity of a patient.Type: GrantFiled: November 30, 2018Date of Patent: November 26, 2019Assignee: NATIONAL CHENG KUNG UNIVERSITYInventors: Ping-Ching Wu, Dar-Bin Shieh, Fong-Yu Cheng, Yuh-Ling Chen
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Patent number: 10220221Abstract: A dental device for treating dental infection includes a dental cast comprising at least one groove to receive teeth and/or gums of a dental arch of the patient; and at least one light diffusing fiber arranged on the dental cast around the at least one groove. The dental device is used in a photodynamic therapeutic system, in which a light source instrument emits light onto a photosensitizer applied in mouth of the patient. The dental device is optically coupled to the light source instrument. The light for treating dental infection of the patient is transmitted by the at least one light diffusing fiber of the dental device and activates the photosensitizer to produce free radicals or oxidants to destroy the bacteria and microbes causing dental disease.Type: GrantFiled: December 28, 2016Date of Patent: March 5, 2019Assignee: Olighter Co., Ltd.Inventor: Ping-Ching Wu
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Publication number: 20180178030Abstract: A photodynamic therapeutic method for treating dental infection of a patient includes the steps of applying a dental device including at least one light diffusing fiber (LDF) to an oral cavity of the patient and providing light from a light source instrument to the at least one LDF of the dental device. The light is introduced into the mouth of the patient for a time period through the at least one LDF of the dental device. The light treats dental infection of the patient by transforming a photosensitizer applied within the mouth into free radicals and oxidants which destroy disease-causing bacteria and microbes.Type: ApplicationFiled: December 28, 2016Publication date: June 28, 2018Inventor: PING-CHING WU
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Publication number: 20180178031Abstract: A dental device for treating dental infection includes a dental cast comprising at least one groove to receive teeth and/or gums of a dental arch of the patient; and at least one light diffusing fiber arranged on the dental cast around the at least one groove. The dental device is used in a photodynamic therapeutic system, in which a light source instrument emits light onto a photosensitizer applied in mouth of the patient. The dental device is optically coupled to the light source instrument. The light for treating dental infection of the patient is transmitted by the at least one light diffusing fiber of the dental device and activates the photosensitizer to produce free radicals or oxidants to destroy the bacteria and microbes causing dental disease.Type: ApplicationFiled: December 28, 2016Publication date: June 28, 2018Inventor: PING-CHING WU
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Patent number: 9339562Abstract: Nanoparticles are used as a contrast agent for magnetic resonance imaging and computed tomography. Each of the nanoparticles includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the surface of the metal alloy core. Also disclosed is a method for using the contrast agent.Type: GrantFiled: March 23, 2011Date of Patent: May 17, 2016Assignees: National Taiwan Normal University, National Cheng Kung UniversityInventors: Chia-Chun Chen, Dar-Bin Shieh, Shang-Wei Chou, Ping-Ching Wu, Yu Hong Hsiao, Yu Sang Yang
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Publication number: 20150368633Abstract: The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.Type: ApplicationFiled: August 27, 2015Publication date: December 24, 2015Inventors: Dar-Bin SHIEH, Hai-Wen CHEN, Chia-Chun CHEN, Ping-Ching WU
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Patent number: 9121049Abstract: The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure, and the size of the nanoparticle is under a controllable range of 3 nm to 150 nm. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.Type: GrantFiled: September 27, 2012Date of Patent: September 1, 2015Assignee: NATIONAL CHENG KUNG UNIVERSITYInventors: Dar-Bin Shieh, Hai-Wen Chen, Chia-Chun Chen, Ping-Ching Wu
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Publication number: 20140228552Abstract: The present invention provides a MRI contrast enhancing agent, which comprises: a magnetic particle with a T2-reducing effect; a polymer coupled to a surface of the magnetic particle; and a T1 contrast agent coupled to the polymer.Type: ApplicationFiled: February 8, 2013Publication date: August 14, 2014Applicant: National Cheng Kung UniversityInventor: Ping-Ching WU
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Publication number: 20140147508Abstract: The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide is connected to a surface of the metal nanoparticle, and the anticancer drug is bound to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.Type: ApplicationFiled: January 29, 2014Publication date: May 29, 2014Applicant: National Cheng Kung UniversityInventors: Dar-Bin SHIEH, Chen-Sheng YEH, Dong-Hwang CHEN, Ya-Na WU, Ping-Ching WU
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Patent number: 8673358Abstract: The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide connects to a surface of the metal nanoparticle, and the anticancer drug binds to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.Type: GrantFiled: July 30, 2010Date of Patent: March 18, 2014Assignee: National Cheng Kung UniversityInventors: Dar-Bin Shieh, Chen-Sheng Yeh, Dong-Hwang Chen, Ya-Na Wu, Ping-Ching Wu
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Publication number: 20130171258Abstract: The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure, and the size of the nanoparticle is under a controllable range of 3 nm to 150 nm. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.Type: ApplicationFiled: September 27, 2012Publication date: July 4, 2013Inventors: Dar-Bin SHIEH, Hai-Wen CHEN, Chia-Chun CHEN, Ping-Ching WU
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Publication number: 20120076737Abstract: Nanoparticles are used as a contrast agent for magnetic resonance imaging and computed tomography. Each of the nanoparticles includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the surface of the metal alloy core. Also disclosed is a method for using the contrast agent.Type: ApplicationFiled: March 23, 2011Publication date: March 29, 2012Applicants: National Cheng Kung University, National Taiwan Normal UniversityInventors: Chia-Chun Chen, Dar-Bin Shieh, Shang-Wei Chou, Ping-Ching Wu
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Publication number: 20120027861Abstract: The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide connects to a surface of the metal nanoparticle, and the anticancer drug binds to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.Type: ApplicationFiled: July 30, 2010Publication date: February 2, 2012Applicant: National Cheng Kung UniversityInventors: Dar-Bin Shieh, Chen-Sheng Yeh, Dong-Hwang Chen, Ya-Na Wu, Ping-Ching Wu
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Publication number: 20050032735Abstract: A method for regulating the skin and hair color in a post-natal mammalian by preparing a recombinant vector in which an agouti-encoding DNA segment is positioned under the control of a promoter and introducing the recombinant vector into skin cells of the mammalian. The recombinant vector carrying the genes expresses related proteins after they are introduced to most mammalian cells.Type: ApplicationFiled: June 4, 2004Publication date: February 10, 2005Applicant: Industrial Technology Research InstituteInventors: Bin-Ru She, Lin-Cheng Yang, Chih-Hsun Yang, Ping-Ching Wu