Abstract: The present invention resides in the discovery that combined use of kuraridin (or any one of its analogs) and epicatechin gallate (ECG) can provide heightened level of antimicrobial activity, especially for the suppression of bacteria of the Staphylococcus aureus and Staphylococcal species. Compositions, kits, and methods for the combination use are disclosed.

Abstract: The present invention resides in the discovery that combined use of kuraridin (or any one of its analogs) and epicatechin gallate (ECG) can provide heightened level of antimicrobial activity, especially for the suppression of bacteria of the Staphylococcus aureus and Staphylococcal species. Compositions, kits, and methods for the combination use are disclosed.

Abstract: The present invention is a herbal composition and method of preparing thereof. The herbal composition comprising extracts of Carthami Flos (CF), Dipsaci Radix (DR), Notoginseng Rhizoma (NR) and Rhei Rhizoma (RR). The present invention also relates to an oil-in-water or water-in-oil type nano-emulsion and method of preparing thereof. The nano-emulsion comprises an aqueous phase, an organic phase and a surfactant, wherein said aqueous phase comprises hydrophilic extract of herbal materials and said organic phase comprises hydrophobic extract of said herbal materials. The present invention also relates to a transdermal patch comprises said nano-emulsion. The herbal composition of the present invention is useful in treating traumatic injuries, in particular bone injuries. The present nano-emulsion and patch thereof can promote skin absorption of active ingredients in herb, thereby increasing the herb's bioavailability and efficacy in therapy.

Abstract: An organic extract of a Chinese herbal medicine Geum Japonicum thunb var. has been identified that displayed potent stimulatory effects on rapid agiogenesis (<24 h), myogenesis and blocking fibrosis in traumatized skeletal muscles. The extract has displayed potent dual effects on angiogenesis and myogenesis in damaged skeletal muscles leading to complete skeletal muscle healing in rabbit and rat animal models. The extract of the present invention can be developed into an effective therapeutic drug for the treatment of skeletal muscle trauma, soft tissue healing including burn, skin wound and operation cut, and bone fracture and defect healings.