Abstract: Disclosed herein an isolated neutralizing antibody, which is capable of specifically binding to chitinase-3-like protein-1 (YKL-40) and uses thereof. The neutralizing antibody can further conjugate with a metal chelator to form an antibody complex. Further, labeling the antibody complex with a radioactive metal nuclide results in formation of a radioactive antibody complex, which can be used as a contrast agent and treatment for YKL-40 over-expression-related diseases. The radioactive antibody complex can specifically bind to YKL-40, and can be used for diagnosis and the preparation of the use of the treatment for cancers related to YKL-40 over-expression.

Abstract: A surface-modified microsphere composition comprises poly(lactic-co-glycolic acid) (PLGA), chitosan, hydrophobic drug, and hydrophilic drug. The PLGA forms a microsphere. The chitosan is formed on a surface of the microsphere. The hydrophobic drug is encapsulated by the microsphere. The hydrophilic drug is adsorbed on the surface of the microsphere. The surface-modified microsphere composition is for treating arthritis. A method of preparing a surface-modified microsphere composition involves producing by an oil-in-water emulsion method microspheres formed from PLGA, covered with chitosan, and adapted to encapsulate hydrophobic drug, and having hydrophilic drug adsorbed on their surfaces. The surface-modified microsphere composition enables drug to be released to achieve efficacy both instantly and persistently.

Abstract: The present invention relates to a biodegradable carrier for carrying a radioisotope, which is formed from at least one biodegradable polymer selected from the group consisting of poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), poly(?-caprolactone) (PCL), chitosan, poly(?-glutamic acid) (PGA), and polyethylene glycol (PE) in which its hydroxyl group is substituted with an amino group and grafted with tetraazocyclododecanetetraacetic acid monosuccinimide ester (DOTA-NHS), in which nitrogen atoms contained in the DOTA-NHS are provided for coordinating with a radioisotope. The present invention also relates to a kit which includes a first container containing the biodegradable carrier for carrying a radioisotope according to the present invention and a second container containing a radioisotope.