Abstract: An image sensor structure includes a semiconductor substrate, a plurality of image sensing elements, a reflective element, and a high-k dielectric structure. The image sensing elements are in the semiconductor substrate. The reflective element is in the semiconductor substrate and between the image sensing elements. The high-k dielectric structure is between the reflective element and the image sensing elements.

Abstract: A semiconductor package including two different adhesives and a method of forming are provided. The semiconductor package may include a package component having a semiconductor die bonded to a substrate, a first adhesive over the substrate, a heat transfer layer on the package component, and a lid attached to the substrate by a second adhesive. The first adhesive may encircle the package component and the heat transfer layer. The lid may include a top portion on the heat transfer layer and the first adhesive, and a bottom portion attached to the substrate and encircling the first adhesive. A material of the second adhesive may be different from a material of the first adhesive.

Abstract: A problem of the present invention is to provide a diagnostic biomarker of nonalcoholic steatohepatitis (NASH) useful for differentiation of simple steatosis (SS) from NASH and use thereof. Specifically, the present invention relates to a diagnostic biomarker of nonalcoholic steatohepatitis used to differentiate nonalcoholic steatohepatitis from simple steatosis comprising the oxidized apolipoprotein A-I (ApoA-I) modified by dioxidation of the 72nd tryptophan in the ApoA-I consisting of the amino acid sequence as shown in SEQ ID NO: 1.

Abstract: Disclosed herein are system, method, and computer program product embodiments for database management coordinators operated by a source server and a target server, respectively. The database management coordinator can be in a state selected from an initial state, a ready state, a transmission state, or a pause state. The database management coordinator operated by the source server can extract data in a first format stored in a first storage device and convert the data in the first format into a second format to be transmitted to the target serer. The database management coordinator operated by the target server can convert the data in the second format into a third format to be stored in a third storage device associated with the target server.

Abstract: Disclosed herein are system, method, and computer program product embodiments for replaying a large concurrency workload. The embodiments disclosed herein may be used to test the workload capacity of a database. An embodiment operates by executing a first database transaction statement to a database. The execution status of the first database transaction statement is checked and the number of work threads connecting to the database is adjusted. In an embodiment, the number of work threads used may be less than the number of sessions simulated.

Abstract: Provided is a method of assisting the detection of nonalcoholic steatohepatitis (NASH), which is far less invasive than liver biopsy and is based on simple operations that do not require skilled technical personnel. The present invention is a method of assisting the detection of NASH, which includes: a) measuring the amount of LDL-TG contained in a test blood sample isolated from a living body; b) measuring the amount of at least one component selected from the group consisting of LDL-C, LDL subfraction-C, IIDL-C, HDL subfraction-C, ApoB, ApoE, total cholesterol, ALT, and AST contained in the test blood sample; and c) determining the possibility of developing and/or having NASH by using the amount of LDL-TG in combination with the amount of the at least one component.

Abstract: Smart vehicle parking apparatus and related methods are disclosed herein. An example system includes a processor to reserve a personal vehicle for a time interval. The personal vehicle is to park at a location during the time interval. The processor is also to match a vehicle use option to the personal vehicle based on the time interval and the location. The vehicle use option is associated with a person to use the personal vehicle during the time interval.

Abstract: Provided are anti-claudin 18.2 (CLDN18.2) antibodies and fragments thereof. Also provided are isolated nucleic acid molecules that encode anti-CLDN18.2 antibodies, vectors comprising such nucleic acid, and host cells comprising such vectors or nucleic acids. Provided are methods of making anti-CLDN18.2. Also provided are related pharmaceutical compositions and methods using such pharmaceutical compositions in the treatment of disorders associated with aberrant CLDN18.2 expression, such as cancers.

Abstract: Disclosed herein are system, method, and computer program product embodiments for database management coordinators operated by a source server and a target server, respectively. The database management coordinator can be in a state selected from an initial state, a ready state, a transmission state, or a pause state. The database management coordinator operated by the source server can extract data in a first format stored in a first storage device and convert the data in the first format into a second format to be transmitted to the target serer. The database management coordinator operated by the target server can convert the data in the second format into a third format to be stored in a third storage device associated with the target server.

Abstract: The present disclosure provides variant CD80 polypeptides that have altered affinity for their cognate binding partners, and immunomodulatory fusion proteins comprising the variant CD80 polypeptides. The present disclosure also provides pharmaceutical compositions comprising such polypeptides and/or proteins and methods for modulating immune responses and/or treatment of cancer, infectious diseases, and/or immunological diseases.

Abstract: Methods and Raman detection agents for detecting an analyte in a sample are provided. Methods described herein may comprise steps of providing a 3D diagnostic substrate presenting a capture agent for the analyte or an analyte complex; exposing the sample to the substrate and to a Raman detection agent, allowing analyte in the sample to bind to the capture agent of the diagnostic substrate and an affinity component of the Raman detection agent; and detecting the Raman detection agent bound to the 3D diagnostic substrate by Raman spectroscopy, thereby detecting the presence of the analyte in the sample. Raman detection agents described herein may comprise a Raman signal-enhancing metal nanoparticle carrying both a Raman reporter and an affinity component for binding to the analyte or the complex formed between the analyte and the capture agent on the 3D diagnostic substrate.

Abstract: An optoelectronic semiconductor structure includes a first n-type semiconductor layer, a first quantum well layer, a first p-type semiconductor layer, and a second n-type semiconductor layer. The first quantum well layer is disposed on the first n-type semiconductor layer. The first p-type semiconductor layer is disposed on the first quantum well layer. The second n-type semiconductor layer is disposed on the first p-type semiconductor layer. The second n-type semiconductor layer includes both an n-type dopant and a p-type dopant. The concentration of the n-type dopant in the second n-type semiconductor layer is greater than the concentration of the p-type dopant in the second n-type semiconductor layer. The first n-type semiconductor layer, the first quantum well layer, the first p-type semiconductor layer, and the second n-type semiconductor layer form a bipolar phototransistor structure. A manufacturing method of the optoelectronic semiconductor structure is also provided.

Abstract: Provided are anti-claudin 18.2 (CLDN18.2) antibodies and fragments thereof. Also provided are isolated nucleic acid molecules that encode anti-CLDN18.2 antibodies, vectors comprising such nucleic acid, and host cells comprising such vectors or nucleic acids. Provided are methods of making anti-CLDN18.2. Also provided are related pharmaceutical compositions and methods using such pharmaceutical compositions in the treatment of disorders associated with aberrant CLDN18.2 expression, such as cancers.

Abstract: Particular embodiments detect an indication of an event that is initiated on an online social network by a user and that is related to an entity associated with an activity that the user has engaged in. Based on the received indication, a social-networking system sends the user a request for follow-up information about the activity. After the follow-up information is received, the social-networking system retrieves contacts of the user and identifies contacts that have engaged in social activities on the online social network related to the entity. Recommendations for the entity are then sent to those identified contacts.

Abstract: Particular embodiments detect events associated with information about events and activities that a user has engaged in. The events may be of a particular type. An entity associated with an event may request that the user provide further information on the event and, based on the received information, the social-networking system sends the user a request for follow-up information after an appropriate time delay. The time delay may vary based on the user activity and the type or context of the event that triggered the request. After the follow-up information is received, such information is stored in the social-networking system and may be used to determine recommendations, sponsored stories, advertisements, etc. to send to friends of the user. The information may also be used for ranking or filtering recommendations.

Abstract: Social networking system users may create events where a group of other users invited to the event meet at a specified time and location. While an inviting user initially specifies the group of users to invite to the event, the social networking system suggests additional users to invite to the event. The social networking system suggests additional users based on a prediction that the users would attend the event if invited. Various factors may be used to make the prediction, such as an affinity between the inviting user and the other users, the availability of the other users at the time of the event and/or the proximity of the other users to the location of the event. Invitations to the suggested additional users may be automatically sent or sent to a set of the additional users selected by the inviting user.

Abstract: An optoelectronic semiconductor structure includes a first n-type semiconductor layer, a first quantum well layer, a first p-type semiconductor layer, and a second n-type semiconductor layer. The first quantum well layer is disposed on the first n-type semiconductor layer. The first p-type semiconductor layer is disposed on the first quantum well layer. The second n-type semiconductor layer is disposed on the first p-type semiconductor layer. The second n-type semiconductor layer includes both an n-type dopant and a p-type dopant. The concentration of the n-type dopant in the second n-type semiconductor layer is greater than the concentration of the p-type dopant in the second n-type semiconductor layer. The first n-type semiconductor layer, the first quantum well layer, the first p-type semiconductor layer, and the second n-type semiconductor layer form a bipolar phototransistor structure. A manufacturing method of the optoelectronic semiconductor structure is also provided.

Abstract: Smart vehicle parking apparatus and related methods are disclosed herein. An example system includes a processor to reserve a personal vehicle for a time interval. The personal vehicle is to park at a location during the time interval. The processor is also to match a vehicle use option to the personal vehicle based on the time interval and the location. The vehicle use option is associated with a person to use the personal vehicle during the time interval.

Abstract: Methods and Raman detection agents for detecting an analyte in a sample are provided. Methods described herein may comprise steps of providing a 3D diagnostic substrate presenting a capture agent for the analyte or an analyte complex; exposing the sample to the substrate and to a Raman detection agent, allowing analyte in the sample to bind to the capture agent of the diagnostic substrate and an affinity component of the Raman detection agent; and detecting the Raman detection agent bound to the 3D diagnostic substrate by Raman spectroscopy, thereby detecting the presence of the analyte in the sample. Raman detection agents described herein may comprise a Raman signal-enhancing metal nanoparticle carrying both a Raman reporter and an affinity component for binding to the analyte or the complex formed between the analyte and the capture agent on the 3D diagnostic substrate.

Abstract: Social networking system users may create events where a group of other users invited to the event meet at a specified time and location. While an inviting user initially specifies the group of users to invite to the event, the social networking system suggests additional users to invite to the event. The social networking system suggests additional users based on a prediction that the users would attend the event if invited. Various factors may be used to make the prediction, such as an affinity between the inviting user and the other users, the availability of the other users at the time of the event and/or the proximity of the other users to the location of the event. Invitations to the suggested additional users may be automatically sent or sent to a set of the additional users selected by the inviting user.