Abstract: The invention relates to a method of treatment comprising administering a long-acting mutant human fibroblast growth factor to a subject in need thereof. The said long-acting mutant human fibroblast growth factor is mPEG-CH2—N?H-mFGF21, wherein mFGF21 consists of SEQ ID NO: 1, and the said new use consists of a method of treating non-alcoholic steatohepatitis.

Abstract: A method, apparatus and device used to search for content, and a computer-readable storage medium, which relate to the field of data processing. In the method, in response to receiving a search request for a target search term, obtain multiple historical search records related to multiple historical search requests, each historical search record comprising the historical search term targeted by the corresponding historical search request. Then, determine a first historical search record matching the target search term from the multiple historical search records. Furthermore, based on the relationship between multiple historical search records, determine from the multiple historical search records a second historical search record associated with the first historical search record. The method further comprises determining an extended result for the target search term on the basis of the search result corresponding to the second historical search record.

Abstract: The present invention discloses a microchannel mixer, comprising a microchannel component and a shell, wherein the microchannel component is fixed inside the shell, wherein an inlet is provided at one end of the shell for feeding liquid and gas phase materials, and an outlet is provided at the other end for discharging the mixed material; said microchannel component comprises multiple stacked sheets and several layers of oleophilic and/or hydrophilic fiber filaments filled in the crevices between adjacent sheets, wherein the fiber filaments form several microchannels between them, and the fiber filaments are clamped and fixed by the sheets. The present invention also discloses a heavy oil hydrogenation reaction system comprising the above-mentioned microchannel mixer and a heavy oil hydrogenation process.

Abstract: Increasingly, human subjects are taking biotin as a medical therapy or nutritional supplement. This practice causes difficulty in analysis of biological samples, such as blood samples, using biotin conjugate reagents since free biotin results in interference. Inventive antibodies, and antigen binding fragments thereof, which specifically bind to biotin of a biotin conjugate and which have a higher affinity for biotin of a biotin conjugate than for free biotin, are provided along with methods of their use.

Abstract: Methods and compositions for treating a disorder of cardiac muscle and/or skeletal muscle in a subject according to aspects of the present disclosure. Treatment methods include administering a therapeutically effective dose of a C-terminal portion of troponin I capable of reducing sensitivity of cardiac muscle and/or skeletal muscle to Ca2+ without decreasing maximum force production. Assays for identification of compounds capable of reducing sensitivity of cardiac muscle and/or skeletal muscle to Ca2+ without decreasing maximum force production are further provided.

Abstract: A library of machine learning primitives is provided to optimize a machine learning model to improve the efficiency of inference operations. In one embodiment a trained convolutional neural network (CNN) model is processed into a trained CNN model via pruning, convolution window optimization, and quantization.

Abstract: A continuous wet ball-milling separation device has a cylinder, which has a feeding section, a shearing section, and a crushing section in sequence from top to bottom. The feeding section is located at the upper portion of the device, and is provided with a liquid inlet, a material inlet, and a material distributor. The shearing section is located in the middle of the device, and is internally provided with shearing blades. The crushing section is located at the lower portion of the device, and is internally provided with stirring rods and crushing balls, and a grading discharge module is provided at the bottom of the crushing section. A grading discharge module is used in the device and a continuous wet ball-milling separation method applying the device. The device implements continuous operations of material crushing and grading by means of the material distributor, wet shearing, wet crushing, and wet grading.

Abstract: The present disclosure relates to a coating composition, comprising: —a resin component containing an epoxy resin and a petroleum resin; —zinc particles in an amount of at least 65 wt.-%, based on the total solid weight of the coating composition; —a metallic salt of phosphorous acid; and —a hardener. In addition, the present disclosure also relates to a multi-part coating form of said coating composition, a method for preparing the coating composition and a substrate coated with the coating composition.

Abstract: The instant application relates to a polysiloxane-based coating composition, comprising: Polysiloxane of formula I wherein each R1 is independently a hydroxyl group or an alkyl, aryl or alkoxy group having up to 6 carbon atoms, each R2 independently is hydrogen or alkyl or aryl group having up to 6 carbon atoms, and n is selected so that the molecular weight for the polysiloxane is 400 to 10000; a non-aromatic epoxide resin having more than one 1, 2-epoxide group per molecule with an epoxide equivalent weight of 100 to 5000; a multi-functional (meth) acrylate monomer; and a cure system comprising at least one alkoxy functional aminosilane. Furthermore, it also relates to a method of coating surface using said coating composition and the substrate coated therewith.

Abstract: A gas purification system includes a dust removal filler, a fouling collection pan and a gas purification device. The dust removal filler has a plurality of rows of channels, each channel extending obliquely with respect to a vertical direction to form a windward surface, and a leeward surface, and a waveform plate. The peak portion of the waveform plate is attached to the leeward surface of the obliquely prismatic channel. During operation, dust adheres to a concave portion of a lower surface of the waveform plate and accumulates to form dust aggregates. When the gravity of the dust aggregates is greater than the adhesion force, the dust aggregates fall onto the windward surface of the channels and slide off from the windward surface of the channels.

Abstract: A process for producing propylene involves dehydration of isopropanol. The dehydration process includes a step of subjecting a starting material containing isopropanol to a dehydration reaction in the presence of a dehydration catalyst comprising alumina to produce a product containing propylene. The starting material has a water content of 0.1 to 10.0 wt % (relative to 100 wt % of the total mass of the starting material), and the product has a total content of C2 unsaturated impurities and C3-C4 unsaturated impurities of 80 ppm or less (relative to 100 wt % of the total mass of the product).

Abstract: A data writing and reading method and apparatus, and a cloud storage system. The data writing method includes an access node receiving a data write request, identifying domain identification information contained in the data write request when failing to obtain an available management node, and querying a pre-saved index according to the domain identification information, wherein the index includes a correspondence between a resource pool and domain identification information, identifying a target resource pool that matches the domain identification information, each resource pool including at least one storage server, determining, from at least one storage server included in the target resource pool, one of the storage servers as a target storage server, and writing data to be written into the target storage server, to ensure that the cloud storage system operates normally without additional cost when all management nodes are at fault or the management node cluster network is abnormal.

Abstract: Methods of amplifying an RNA template according to aspects of the present disclosure include: providing a composition including a recombinant thermostable DNA polymerase including SEQ ID NO:1, or a variant thereof having at least 99% identity to SEQ ID NO:1; and a reaction buffer, the reaction buffer including 10-30 mM Tris-HCl, pH 8.5-9.0; 20-40 mM KCl; 5-15 mM (NH4)2SO4; 1.5-3.5 mM Mn2+; 0.01-0.20% (w/v) gelatin and/or serum albumin; 0.05-0.15% (w/v) of a nonionic detergent; with the proviso that no more than 0.1 mM of Mg2+ is present in the composition; and, optionally, 0.01-0.1 mM of a chelating agent is present in the composition.

Abstract: A production system for insoluble sulfur includes a polymeric kettle having a first discharge port and a quench tower (200) having a feed port. The first discharge port is in communication with the feed port. The quench tower has a cylindrical housing, a granulation device and a shear pump. A solvent inlet and a quenching agent inlet, which are respectively used for providing a solvent and a quenching agent, are arranged on the side wall of the housing. The sulfur production method includes raising the temperature of liquid sulfur under the protection of an initiator and nitrogen to perform polymerization reaction; introducing the polymerized material into the quenching tower and sequentially carrying out granulation and quenching treatment; carrying out solvent curing and extraction integrated treatment on the quenched product; and carrying out liquid phase circulating crushing and extraction integrated treatment on the cured and extracted product.

Abstract: The present disclosure relates to the technical field of water purifying material, and in particular to a kaolin-based water purifying material, a preparation method and use thereof. The method for preparing a kaolin-based water purifying material provided by the present disclosure includes the following steps: mixing kaolin and a modifier with water, and conducting hydrothermal reaction to obtain a kaolin-based water purifying material; the modifier is an organic or inorganic modifier; the organic modifier is octadecyl trimethyl ammonium chloride (OTAC), and the inorganic modifier is one or more of polyaluminum chloride, Al2(SO4)3, Fe2(SO4)3, AlCl3 and FeCl3; the kaolin is 200-400 mesh in particle size. The water purifying material of the present disclosure enables efficient algae removal and water purification, and is safe and eco-friendly.

Abstract: This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of sodium-glucose cotransporter (SGLT) activity. The invention further relates to methods of treating and/or ameliorating symptoms related to cystic fibrosis (CF), comprising administering to a subject (e.g., a human patient) a composition comprising one or more pharmaceutical agents which function as inhibitors of SGLT activity.

Abstract: A washing and desalting device includes a first shell and a plurality of filaments. The first shell has a first receiving cavity and is provided with a liquid inlet and a liquid outlet that communicate with the first receiving cavity. The plurality of the filaments is provided in the first receiving cavity, and the length direction of each of the filaments is consistent with that of the first receiving cavity. The device can be incorporated in a washing and dehydrating system.

Abstract: The present disclosure relates to the technical field of water purifying material, and in particular to a kaolin-based water purifying material, a preparation method and use thereof. The method for preparing a kaolin-based water purifying material provided by the present disclosure includes the following steps: mixing kaolin and a modifier with water, and conducting hydrothermal reaction to obtain a kaolin-based water purifying material; the modifier is an organic or inorganic modifier; the organic modifier is octadecyl trimethyl ammonium chloride (OTAC), and the inorganic modifier is one or more of polyaluminum chloride, Al2(SO4)3, Fe2(SO4)3, AlCl3 and FeCl3; the kaolin is 200-400 mesh in particle size. The water purifying material of the present disclosure enables efficient algae removal and water purification, and is safe and eco-friendly.

Abstract: Methods for detecting a cardiac condition in a human subject are provided according to aspects of the present invention which include providing an immunological reagent characterized by specific binding to: an N-terminal fragment of human cardiac troponin T (HcTnT-N69) or a neoepitope of human cardiac troponin T generated by removal of HcTnT-N69 from HcTnT (HcTnT-neo); contacting the immunological reagent with a biological sample of the human subject under binding conditions; and detecting binding of the immunological reagent with HcTnT-N69 or HcTnT-neo, wherein detection of HcTnT-N69 or HcTnT-neo in the biological sample is indicative of a cardiac condition in the subject. Antibodies and antigen binding fragments thereof characterized by specific binding to HcTnT-N69 or HcTnT-neo, or a variant of either thereof, are provided according to aspects of the present invention.

Abstract: Automatic append includes: identifying, based at least in part on contents of a first data set comprising a first plurality of columns and contents of a second data set comprising a second plurality of columns, a plurality of matching columns and a plurality of non-matching columns. The matching columns comprise one or more columns among the first plurality of columns; and corresponding one or more matching columns among the second plurality of columns. The non-matching columns comprise: one or more columns among the first plurality of columns that do not match with any columns among the second plurality of columns; and one or more columns among the second plurality of columns that do not match with any columns among the first plurality of columns.