Patents by Inventor Ping Lan
Ping Lan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240400583Abstract: Compounds of formula I, that modulate DCAF15 and induce RBM139 protein degradation, pharmaceutical compositions containing these compounds, and methods of using these compounds for treating diseases associated with RBM39 protein activity and DCAF15 modulation are described herein.Type: ApplicationFiled: October 7, 2022Publication date: December 5, 2024Applicant: Merck Sharp & Dohme LLCInventors: John P. Caldwell, Ping Lan, Hongwu Wang, Paul Wehn
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Patent number: 11881132Abstract: A display panel and a display device. The display panel includes a test circuit located in a non-display region. The test circuit includes a plurality of switching transistors and at least one data switching line extending in a first direction. In each switching transistor, a first end of the switching transistor is electrically connected to a data line in the display panel, and a second end of the switching transistor is configured to receive a test data signal. The data switching line is disposed in the same layer as a source-drain layer of the switching transistor. The data switching line is configured to control the switching transistor to be turned on or off.Type: GrantFiled: May 10, 2022Date of Patent: January 23, 2024Assignee: YUNGU (GU'AN) TECHNOLOGY CO., LTD.Inventors: Ping Lan, Jiazuo Cai, Jiading Liu
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Patent number: 11465190Abstract: An object of the present invention is to provide a bending die that has a simple configuration and is capable of bending a rod-shaped body in a three-dimensional XYZ direction quickly and reliably, the bending die comprising a pair of forming dies clamped in a Z direction, wherein the forming dies have, respectively, rod-shaped body-forming recess portions, and rod-shaped body guide portions for guiding a rod-shaped body to the rod-shaped body-forming recess portions, the rod-shaped body-forming recess portions are each formed into a shape with a semicircular cross section that defines, between the forming dies when clamping the forming dies, a long, cylindrical cavity for forming the rod-shaped body bent in a three-dimensional XYZ direction, and the rod-shaped body guide portions are each formed into a V-shape that spreads outward from both sides of each of the rod-shaped body-forming recess portions having a semicircular cross section.Type: GrantFiled: September 25, 2018Date of Patent: October 11, 2022Assignee: SANOH INDUSTRIAL CO., LTD.Inventors: Guang Ping Lan, Kazuhiko Nakazato
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Publication number: 20220288840Abstract: An object is to provide a thermoplastic tube bending method that suppresses springback after the processing by a highly safe and short bending step. The thermoplastic tube bending method includes a step S1 of preheating the thermoplastic tube, a step S2 of bending the preheated thermoplastic tube by using a forming mold, and a step S3 of forming the bent thermoplastic tube by temperature control of an electric heater provided to the forming mold.Type: ApplicationFiled: April 6, 2020Publication date: September 15, 2022Inventors: Guang Ping LAN, Kazuhiko NAKAZATO, Takaaki HABU, Kazuki YASURAOKA
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Publication number: 20220270529Abstract: A display panel and a display device. The display panel includes a test circuit located in a non-display region. The test circuit includes a plurality of switching transistors and at least one data switching line extending in a first direction. In each switching transistor, a first end of the switching transistor is electrically connected to a data line in the display panel, and a second end of the switching transistor is configured to receive a test data signal. The data switching line is disposed in the same layer as a source-drain layer of the switching transistor. The data switching line is configured to control the switching transistor to be turned on or off.Type: ApplicationFiled: May 10, 2022Publication date: August 25, 2022Applicant: YUNGU (GU'AN) TECHNOLOGY CO., LTD.Inventors: Ping LAN, Jiazuo CAI, Jiading LIU
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Patent number: 11161819Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.Type: GrantFiled: July 22, 2020Date of Patent: November 2, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Gregory L. Adams, Jason M. Cox, John S. Debenham, Scott Edmondson, Eric J. Gilbert, Yan Guo, Yu Jiang, Hubert Josien, Hyunjin M. Kim, Ping Lan, Shouwu Miao, Christopher W. Plummer, Murali Rajagopalan, Unmesh Shah, Zhongxiang Sun, Quang T. Truong, Feroze Ujjainwalla, Francisco Velazquez, Srikanth Venkatraman, Takao Suzuki, Nengxue Wang
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Patent number: 10953448Abstract: A method for bending a pipe by, while sandwiching one portion of the pipe by a gripping device, sandwiching the other portion of the pipe between a pair of bending rolls and by causing the other bending roll to relatively revolve about one bending roll out of the pair of bending rolls, wherein the bending rolls are held by a common movable frame body, the relative revolution is realized by synchronous movement in which rotating movement for rotating the frame body and lateral movement for moving the frame body in a direction (Y-axis direction) perpendicular to a longitudinal direction (X-axis direction) of the pipe are synchronized with each other, and the movement in the Y-axis direction of the frame body is performed such that a position in the Y-axis direction of a center axis of the one bending roll is held and a position in the X-axis direction of a rotating center point of the rotating movement remains same.Type: GrantFiled: April 25, 2016Date of Patent: March 23, 2021Assignee: SANOH INDUSTRIAL CO., LTD.Inventor: Guang Ping Lan
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Patent number: 10888964Abstract: A chuck mechanism enables downsizing of the device with a simple structure, has a wide open/close width of clamps, and hardly causes a dent or scar on pipes. The chuck mechanism includes a horizontally arranged shaft, a frame, a pair of dog leg shaped link members, parallel link members, a pair of clamp members, and a swing drive mechanism.Type: GrantFiled: April 25, 2016Date of Patent: January 12, 2021Assignee: SANOH INDUSTRIAL CO., LTD.Inventor: Guang Ping Lan
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Patent number: 10875851Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.Type: GrantFiled: November 13, 2017Date of Patent: December 29, 2020Assignee: MERCK SHARP & DOHME CORP.Inventors: Ashwin U. Rao, Brian Alexander McKittrick, Matthew Lombardo, Jacqueline D. Hicks, Amy Bittner McCracken, Hong Dong Chu, Sung-Sau So, Peter Orth, Zhicai Wu, Ping Lan, John S. Debenham, Brent R. Whitehead, Jerry A. Taylor, Zhongxiang Sun, Revathi Reddy Katipally, Jonathan E. Gable, Markus K. Dahlgren, Sathesh P. Bhat
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Patent number: 10864211Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.Type: GrantFiled: December 11, 2017Date of Patent: December 15, 2020Assignee: Merck Sharp & Dohme Corp.Inventors: John S. Debenham, Jason M. Cox, Ping Lan, Zhongxiang Sun, Zhe Feng, Chunrui Sun, W. Michael Seganish, Zhong Lai, Cheng Zhu, Thomas Bara, Murali Rajagopalan, Qun Dang, Hyunjin M. Kim, Bin Hu, Jinglai Hao
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Publication number: 20200346266Abstract: An object of the present invention is to provide a bending die that has a simple configuration and is capable of bending a rod-shaped body in a three-dimensional XYZ direction quickly and reliably, the bending die comprising a pair of forming dies clamped in a Z direction, wherein the forming dies have, respectively, rod-shaped body-forming recess portions, and rod-shaped body guide portions for guiding a rod-shaped body to the rod-shaped body-forming recess portions, the rod-shaped body-forming recess portions are each formed into a shape with a semicircular cross section that defines, between the forming dies when clamping the forming dies, a long, cylindrical cavity for forming the rod-shaped body bent in a three-dimensional XYZ direction, and the rod-shaped body guide portions are each formed into a V-shape that spreads outward from both sides of each of the rod-shaped body-forming recess portions having a semicircular cross section.Type: ApplicationFiled: September 25, 2018Publication date: November 5, 2020Inventors: Guang Ping LAN, Kazuhiko NAKAZATO
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Publication number: 20200347020Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.Type: ApplicationFiled: July 22, 2020Publication date: November 5, 2020Applicant: Merck Sharp & Dohme Corp.Inventors: Gregory L. Adams, Jason M. Cox, John S. Debenham, Scott Edmondson, Eric J. Gilbert, Yan Guo, Yu Jiang, Hubert Josien, Hyunjin M. Kim, Ping Lan, Shouwu Miao, Christopher W. Plummer, Murali Rajagopalan, Unmesh Shah, Zhongxiang Sun, Quang T. Truong, Feroze Ujjainwalla, Francisco Velazquez, Srikanth Venkatraman, Takao Suzuki, Nengxue Wang
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Publication number: 20200331053Abstract: An object of the present invention is to provide a bending die that has a simple configuration and is capable of bending a rod-shaped body in a three-dimensional XYZ direction quickly and reliably. The bending die includes XY-plane forming dies that are to be clamped in an X direction to bend the rod-shaped body in an XY plane, and Z-direction forming dies that are to be clamped in a Z direction to bend the rod-shaped body in the Z direction, wherein when both the XY-plane forming dies and the Z-direction forming dies are clamped, a cavity that forms the rod-shaped body bent in the three-dimensional XYZ direction is defined therebetween.Type: ApplicationFiled: September 20, 2018Publication date: October 22, 2020Inventors: Guang Ping LAN, Kazuhiko NAKAZATO
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Publication number: 20190352294Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.Type: ApplicationFiled: November 13, 2017Publication date: November 21, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Ashwin U. Rao, Brian Alexander McKittrick, Matthew Lombardo, Jacqueline D. Hicks, Amy Bittner McCracken, Hong Dong Chu, Sung-Sau So, Peter Orth, Zhicai Wu, Ping Lan, John S. Debenham, Brent R. Whitehead, Jerry A. Taylor, Zhongxiang Sun, Revathi Reddy Katipally, Jonathan E. Gable, Markus K. Dahlgren, Sathesh P. Bhat
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Publication number: 20190269679Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.Type: ApplicationFiled: December 11, 2017Publication date: September 5, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: John S. Debenham, Jason M. Cox, Ping Lan, Zhongxiang Sun, Zhe Feng, Chunrui Sun, Michael W. Seganish, Zhong Lai, Cheng Zhu, Thomas Bara, Murali Rajagopalan, Qun Dang, Hyunjin M. Kim, Bin Hu, Jinglai Hao
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Publication number: 20190161448Abstract: The present invention relates to a compound represented by formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.Type: ApplicationFiled: May 19, 2017Publication date: May 30, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Gregory L. Adams, Jason M. Cox, John S. Debenham, Scott Edmondson, Eric J. Gilbert, Yan Guo, Yu Jiang, Hubert Josien, Hyunjin M. Kim, Ping Lan, Shouwu Miao, Christopher W. Plummer, Murali Rajagopalan, Unmesh Shah, Zhongxiang Sun, Quang T. Truong, Feroze Ujjainwalla, Francisco Velazquez, Srikanth Venkatraman, Takao Suzuki, Nengxue Wang
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Publication number: 20180126436Abstract: A method for bending a pipe by, while sandwiching one portion of the pipe by a gripping device, sandwiching the other portion of the pipe between a pair of bending rolls and by causing the other bending roll to relatively revolve about one bending roll out of the pair of bending rolls, wherein the bending rolls are held by a common movable frame body, the relative revolution is realized by synchronous movement in which rotating movement for rotating the frame body and lateral movement for moving the frame body in a direction (Y-axis direction) perpendicular to a longitudinal direction (X-axis direction) of the pipe are synchronized with each other, and the movement in the Y-axis direction of the frame body is performed such that a position in the Y-axis direction of a center axis of the one bending roll is held and a position in the X-axis direction of a rotating center point of the rotating movement remains same.Type: ApplicationFiled: April 25, 2016Publication date: May 10, 2018Inventor: Guang Ping LAN
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Publication number: 20180111236Abstract: A chuck mechanism enables downsizing of the device with a simple structure, has a wide open/close width of clamps, and hardly causes a dent or scar on pipes. The chuck mechanism includes a horizontally arranged shaft, a frame, a pair of dog leg shaped link members, parallel link members, a pair of clamp members, and a swing drive mechanism.Type: ApplicationFiled: April 25, 2016Publication date: April 26, 2018Inventor: Guang Ping LAN
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Patent number: 9708270Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.Type: GrantFiled: October 11, 2013Date of Patent: July 18, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Mariappan Chelliah, Hong Dong Chu, Jason M. Cox, John S. Debenham, Keith Eagen, Ping Lan, Clare London, Michael A. Plotkin, Unmesh Shah, Christopher Joseph Sinz, Zhongxiang Sun, Henry M. Vaccaro, Srikanth Venkatraman
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Patent number: 9487506Abstract: Compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases are disclosed. Processes for preparing compounds of the Formula (I), use of the compounds for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and pharmaceutical compositions which comprise compounds of the Formula (I) are disclosed.Type: GrantFiled: April 11, 2012Date of Patent: November 8, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Ping Lan, Kun Liu, Anthony Ogawa, Hong Shen, Christine Yang, Yuguang Wang, Richard Beresis, Changhe Qi