Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: A neutron capture therapy system, which can reduce secondary radiation and radiation damage caused by the action of recoil neutrons generated in the process of generating neutron beams by a beam transmission portion and a neutron beam generation portion. The neutron capture therapy system comprises an accelerator, the beam transmission portion, and the neutron beam generation portion; the accelerator accelerates charged particles to generate charged particle beams; the beam transmission portion transmits the charged particle beams generated by the accelerator to the neutron beam generation portion; the neutron beam generation portion generates neutron beams for treatment; and the neutron capture therapy system comprises a beam transmission shielding component for the beam transmission portion.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: Subject matter disclosed herein relates to sealant for tire repairing and more particularly, relates to sealant composition for repairing tire punctures and a method of preparing the same.

Abstract: Subject matter disclosed herein relates to sealant for tire repairing and more particularly, relates to sealant composition for repairing tire punctures and a method of preparing the same.

Abstract: A sleeve accessory for a portable electronic device includes a plurality of layers stitched together and defining at least one pocket. An adhesive layer is provided for mounting the sleeve accessory with a back panel portion of the portable electronic device. The at least one pocket provides a user with the ability to retain one or more personal items of information therein.

Abstract: A display includes a display panel and a touch panel with a multilayer structure disposed on the display panel. The touch panel includes an ITO film, a transparent electroconductive layer and an electrode pattern layer stacked vertically. The electrode pattern layer includes two parallel X-side electrodes and two parallel Y-side electrodes, all of which surround a rectangular area and are disposed on a peripheral portion of the transparent electroconductive layer. A mother glass layer is stacked above a side surface of the electrode pattern layer opposite to the transparent electroconductive layer. Thus, the touch panel needs not the processing of the surface hard layer, so that the manufacturing processes are simplified, the production yield is increased and the manufacturing cost is reduced. Meanwhile, the interference of electromagnetic waves on the transparent electroconductive layer and the electrode pattern layer can be reduced, and the touch certainty and precision can be enhanced.

Abstract: A touch panel of a display disposed on a display panel includes a transparent substrate, a transparent electroconductive layer and an electrode pattern layer vertically stacked together. The electrode pattern layer includes two opposite parallel X-side electrodes and two opposite parallel Y-side electrodes, all of which surround a rectangular area and are disposed on a periphery of the transparent electroconductive layer. Also, a plastic film is disposed on a side surface of the electrode pattern layer opposite the transparent electroconductive layer. Thus, the touch panel needs not the processing of the surface hard layer, so that the manufacturing processes are simplified, the production yield is increased and the manufacturing cost is reduced when the large-scale touch panel is manufactured. Meanwhile, the interference of electromagnetic waves on the transparent electroconductive layer and the electrode pattern layer can be reduced, and the touch certainty and precision can be enhanced.

Abstract: A display includes a display panel and a touch panel with a multilayer structure. The touch panel includes a transparent substrate, a transparent electroconductive layer and an electrode pattern layer stacked vertically. The electrode pattern layer includes two parallel X-side electrodes and two parallel Y-side electrodes, all of which surround a rectangular area and are disposed on a peripheral portion of the transparent electroconductive layer. A mother glass layer is stacked above a side surface of the electrode pattern layer opposite to the transparent electroconductive layer. Thus, the touch panel needs not the processing of the surface hard layer, so that the manufacturing processes are simplified, the production yield is increased and the manufacturing cost is reduced. Meanwhile, the interference of electromagnetic waves on the transparent electroconductive layer and the electrode pattern layer can be reduced, and the touch certainty and precision can be enhanced.

Abstract: The invention relates to a surface capacitive touch panel capable of simultaneously determining different touch points, and a method thereof. The touch panel includes a transparent substrate, a transparent electroconductive layer and an electrode pattern layer. The electrode pattern layer includes at least one first X-side electrode, at least one second X-side electrode, at least one first Y-side electrode and at least one second Y-side electrode, which surround a rectangular area and are formed on a surface periphery of the transparent electroconductive layer. The impedances of the X-side and Y-side electrodes are configured in an ascending manner or a descending manner with a common difference or a common ratio toward the same side, so that impedances of two touch points on the same horizontal or vertical line of the touch panel have a gradient phenomenon to prevent currents from offsetting each other when the two touch points are moved.

Abstract: A touch panel of a display has an impedance adjusting structure for enhancing the detection precision of touch points and includes a transparent substrate, a transparent electroconductive layer and an electrode pattern layer. The electrode pattern layer includes two parallel X-side electrodes and two parallel Y-side electrodes, which surround a rectangular area and are formed on a periphery portion of the electroconductive layer. Each of the X-side and Y-side electrodes is composed of carbon paste sections and silver paste sections arranged in a neighboring manner. Output currents of the X-side and Y-side electrodes are adjusted according to ratios of the carbon paste sections to the silver paste sections, wherein the carbon/silver paste sections are spaced apart by gaps, which are the same, ascend or descend. According to the design, the specific impedance adjustment of the electrode pattern layer can be performed according to the special requirement in the used environment.

Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.

Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.