Abstract: The present disclosure provides a preparation method of a non-natural anti-human CD45RA murine chimeric antigen receptor (CAR). In the present disclosure, eukaryotic expression vectors pcDNA3.1/Mu3A4-4-1BB-3? and pcDNA3.1/Mu3A4-4-1BB-3?-EGFP and a lentiviral expression vector pLenti/Mu3A4-4-1BB-3? are constructed based on molecular biology using a mouse-derived 3A4 antibody. The lentiviral expression vector pLenti/Mu3A4-4-1BB-3? can successfully infect human T cells and effectively kill 3A4-positive target cells such as KG1a cells and Raji cells. The recognition of antigens by Mu3A4CAR does not depend on antigen presentation process and is not restricted by a major histocompatibility complex (MHC), thus overcoming tumor immune evasion to kill 3A4-positive tumor cells more effectively.

Abstract: Disclosed herein is a drug complex having a synthetic peptide, which has an amino acid sequence of SEQ ID: NO.1; a metal chelator coupled to the synthetic peptide; and a peptide chain disposed between the synthetic peptide and the metal chelator, wherein the peptide chain is composed of plural glutamate molecules.

Abstract: A quantitative prediction method for gas content of deep marine shale includes: obtaining raw data of known wells; establishing relationship formulas between pore specific surface areas and adsorbed gas contents of a known well in an area as an adsorbed gas content quantitative prediction model; establishing relationship formulas between pore volumes and free gas contents of the known well as a free gas content quantitative prediction model; summing the adsorbed gas contents and corresponding free gas contents to obtain total gas contents; calculating adsorbed gas contents, free gas contents and total gas contents of the known wells; drawing a predicted adsorbed gas content contour map, a predicted free gas content contour map and a predicted total gas content contour map; and reading an adsorbed gas content, a free gas content and a total gas content of an unknown well in the area from the above contour maps.

Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.

Abstract: A method may include receiving a digital model of a dental appliance, the digital model may have a plurality of caps. Each cap of the plurality of caps may represent a set of contact points on a tooth. The digital model may have a plurality of links. Each link of the plurality of links may represent a connection between a plurality of caps. The method may include generating a relaxed model of a dental appliance using the digital model of the dental appliance. The method may also include generating a deformed model of the dental appliance using the digital model of the dental appliance and transforming the relaxed model to the deformed model to generate a plurality of parameters for moving the teeth of the patient towards a target tooth arrangement.

Abstract: A method for controlling infusion of a medication into a patient includes obtaining a rise time of a second infusion device; determining a first infusion end time of a first infusion device; and outputting a pre-start message to the second infusion device at a time at as far in advance of the least before the first infusion end time as the rise time. The second infusion device reaches a target infusion rate before the first infusion end time, so that after the end of the infusion of the first infusion device, the second infusion device can directly start the infusion at the target infusion rate. This avoids large flow rate fluctuations and provides continuous, uninterrupted infusion at a desired, more stable rate, reducing the probability of large changes in the patient's vital signs and improving the safety of the infusion.

Abstract: Provided are an array substrate and an electronic apparatus. The array substrate includes: a base substrate; a first conductive layer on the base substrate, where the first conductive layer includes a plurality of pads, each pad includes a first metal layer, a material of the first metal layer includes Cu, a content of the Cu is greater than or equal to 99%, and a thickness of the first metal layer is greater than 2 ?m; and an electronic element disposed on a side of the first conductive layer facing away from the base substrate, where the electronic element includes an electronic element body and a plurality of pins disposed on a side of the electronic element body facing the base substrate, and the pins are connected with the pads.

Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.

Abstract: A cryogenic storage tank includes an inner tank, a shell and two support assemblies supported between the inner tank and the shell. The two support assemblies are provided on two opposite ends of the inner tank along the axis of the inner tank. The support assemblies all include a plurality of support members, and the plurality of support members of each support assembly are symmetrically provided with respect to the vertical centre axis plane of the inner tank, and each of the upper side and the lower side of the horizontal centre axis plane of the inner tank is provided with support members; each support member includes an inner end connected to the outer end of the inner tank and an outer end connected to the inner wall of the shell, and the support member is located in a different plane from the axis of the inner tank.

Abstract: The present invention provides a method of treating targeted abnormal cells that are resistant, refractory, insensitive, non-responsive, or inadequately responsive to an ingredient, as well as cytotoxic cells used therein, comprising administering an effective amount of the ingredient-complexed cytotoxic cells to a subject with the disease.

Abstract: An optical communication module, a device and a system are provided. The optical communication module includes: an electrical communication unit, an exchanging communication mainboard, a first optical transceiving unit and a second optical transceiving unit. The first optical transceiving unit and the second optical transceiving unit respectively receive an optical signal from and/or send an optical signal to a first device and a second device and complete conversion from or to the optical signal, and by the first optical transceiving unit and the second optical transceiving unit, devices connected with the electrical communication unit, the first device and the second device form a network that has a function of a self-healing ring network.

Abstract: A method for digital treatment planning may include defining a set of contact points on a tooth of a patient's dentition and a plurality of connections between pairs of the plurality of contact points. The plurality of connections may include Hookian stiffness parameters of a dental appliance between the plurality of contact points. The method may also include generating a relaxed model of a dental appliance using the plurality of contact points and the plurality of connections. The method may also include generating a deformed model of the dental appliance using the plurality of contact points and plurality of connections. The method may also include transforming the relaxed model to the deformed model to direct the patient dentition towards a target tooth arrangement.

Abstract: A head-mounted device comprises a main body, a monitor-base, at least one monitor, and a sensor. The main body is mounted on a head. The monitor moves with the monitor-base. The sensor is mounted on the main body or the monitor-base and used for detecting a state of the head. A visual field is defined as a maximum area seen by eyes of the user, and an area of the virtual image is smaller than the visual field. The at least one monitor is movable by moving the monitor-base relative to the main body according to the state of the head, detected by the sensor, to adjust a relative angle of the monitor to the eyes such that a relative position of the virtual image in the visual field is adjusted, to ensure that the user sees the virtual image. An augmented reality device is also disclosed.

Abstract: A head-mounted device comprises a main body, a monitor-base, a monitor, and an adjusting component. The main body is mounted on a user's head. The monitor moves with the monitor-base. An eyes-monitor distance is defined between the user's eyes and the monitor. A visual range is defined by a range seen by the user's eyes through the monitor. The adjusting component is configured for pulling or pushing the monitor-base towards the user's eyes to prevent the eyes-monitor distance from increasing and to prevent the visual range from decreasing. When the user wears a pair of glasses between the user's eyes and the monitor, and the glasses block the monitor causing the eyes-monitor distance to be larger than a preset distance, the adjusting component pulls or pushes the monitor-base until the monitor contacts the glasses, to prevent the eyes-monitor distance from increasing. An augmented reality device is also disclosed.

Abstract: A field-effect transistor (FET) based synchronous rectifier for emulating a diode, comprising: a first terminal (20) and a second terminal (30); a first FET (M1) and a second FET (M2), wherein the second FET (M2) is adapted to control operation of the first FET (M1) to thereby allow unidirectional current flow when the two terminals (20, 30) are connected with an external circuit; and wherein the FET based synchronous rectifier comprises a fully integrated single-chip device (10) adapted to emulate a diode.

Abstract: The present disclosure relates to a magnon spin valve device, a magnon sensor, a magnon field effect transistor, a magnon tunnel junction and a magnon memory. A magnon spin valve device may comprise a first ferromagnetic insulation layer, a non-magnetic conductive layer disposed on the first ferromagnetic insulation layer, and a second ferromagnetic insulation layer disposed on the non-magnetic conductive layer.

Abstract: A method for digital treatment planning may include defining a set of contact points on a tooth of a patient's dentition and a plurality of connections between pairs of the plurality of contact points. The plurality of connections may include Hookian stiffness parameters of a dental appliance between the plurality of contact points. The method may also include generating a relaxed model of a dental appliance using the plurality of contact points and the plurality of connections. The method may also include generating a deformed model of the dental appliance using the plurality of contact points and plurality of connections. The method may also include transforming the relaxed model to the deformed model to direct the patient dentition towards a target tooth arrangement.

Abstract: A remote collaboration method applied to a remote device is provided. In the method, the remote device receives a first image transmitted by a wearable device and determines a reference area based on the first image. The remote device further determines a position of a target object relative to the reference area and generates the indication information according to the position of the target object relative to the reference area and transmits the indication information to the wearable device. The method can provide a user with the indication information of the position of the target object in the eyesight through remote collaboration between the remote device and the wearable device, thereby improving the efficiency and accuracy of determining the position of the target object.

Abstract: Systems and methods of generating an orthodontic model are disclosed. The method may include: generating an initial model of a patient dentition; generating a target model of the patient dentition; defining a plurality of caps and a plurality of links, wherein each link connects two of the plurality of caps; generating a relaxed model of a dental appliance from the plurality of caps and the plurality of links; generating a deformed model of a dental appliance from the plurality of caps and plurality of links; and determining a plurality of movements, wherein the plurality of moments transform the relaxed model to the deformed model and wherein the moments are configured to direct the patient dentition from the initial model to the target model.

Abstract: Systems and methods of generating an orthodontic model are disclosed. The method may include: generating an initial model of a patient dentition; generating a target model of the patient dentition; defining a plurality of caps and a plurality of links, wherein each link connects two of the plurality of caps; generating a relaxed model of a dental appliance from the plurality of caps and the plurality of links; generating a deformed model of a dental appliance from the plurality of caps and plurality of links; and determining a plurality of movements, wherein the plurality of moments transform the relaxed model to the deformed model and wherein the moments are configured to direct the patient dentition from the initial model to the target model.