Abstract: The disclosure provides nucleic acid constructs comprising a transmembrane reporter cassette encoding an affinity tag, a transmembrane (TM) domain and a fluorescent reporter protein. In embodiments, the nucleic acid constructs are inserted in a safe harbor locus or an immunoglobulin constant domain locus of in a cell of a non-human mammal. In embodiments, when the transmembrane reporter cassette is expressed in the cell, the affinity tag is displayed on a surface of the cell while the fluorescent reporter protein is located inside the cell membrane. The presence of the affinity tag and the fluorescent reporter protein allow for identification, sorting and/or isolation of cells expressing the nucleic acid constructs. The disclosure also provides embodiments of methods of modifying cells and non-human organisms with the nucleic acid constructs, along with embodiments of cells and non-human organisms produced using the disclosed methods.

Abstract: Disclosed are 3,4-methylenedioxyphenylimidazolylethanonexime ether derivatives, a preparation method and use thereof, and a drug for the treatment of Alzheimer's disease, which relates to the technical field of preparation of acetophenone oxime ether compounds. The (Z)-3,4-methylenedioxyphenylimidazolylethanonexime ether derivatives provided by the present disclosure show a significant effect on the inhibition of NO production, with an EC50 of 2.07-5.41 ?mol/L. Compared with the positive control group of quercetin (with an EC50 of 9.56 ?mol/L) and oxiconazole (with an EC50 of 13.5 ?mol/L), the inhibitory effect is stronger without significant cytotoxicity (cell viability >90%), which can be used to prepare drugs for the treatment of Alzheimer's disease.

Abstract: Disclosed are 3,4-methylenedioxyphenylimidazolylethanonexime ether derivatives, a preparation method and use thereof, and a drug for the treatment of Alzheimer's disease, which relates to the technical field of preparation of acetophenone oxime ether compounds. The (Z)-3,4-methylenedioxyphenylimidazolylethanonexime ether derivatives provided by the present disclosure show a significant effect on the inhibition of NO production, with an EC50 of 2.07-5.41 ?mol/L. Compared with the positive control group of quercetin (with an EC50 of 9.56 ?mol/L) and oxiconazole (with an EC50 of 13.5 ?mol/L), the inhibitory effect is stronger without significant cytotoxicity (cell viability >90%), which can be used to prepare drugs for the treatment of Alzheimer's disease.

Abstract: A system includes reception of a filter on a first dimension of a first data model, determination of an association between a second dimension of the first data model and a first dimension of a second data model, generation of a calculated dimension based on the second dimension, the rows of the calculated dimension being identical to the rows of the first dimension, application of the filter to the rows of the calculated dimension to generate filtered rows of the calculated dimension, execution of an inner join between the filtered rows of the calculated dimension and a fact table of the second data model to generate a result table including one or more measure values of the second data model, and generation of a visualization including the result table.

Abstract: Some embodiments provide execution of a query on a target data model which is filtered on a measure of a source data model, even if the source data model and the target data model are not logically linked. Some embodiments further support execution of a query on a target data model which is filtered on a measure of a source data model and on a dimension filter of another data model. Some embodiments provide for a substantial amount of query execution to occur on the backend, thereby freeing client resources in comparison to prior approaches.

Abstract: Some embodiments provide execution of a query on a target data model which is filtered on a measure of a source data model, even if the source data model and the target data model are not logically linked. Some embodiments further support execution of a query on a target data model which is filtered on a measure of a source data model and on a dimension filter of another data model. Some embodiments provide for a substantial amount of query execution to occur on the backend, thereby freeing client resources in comparison to prior approaches.

Abstract: A system includes reception of a filter on a first dimension of a first data model, determination of an association between a second dimension of the first data model and a first dimension of a second data model, generation of a calculated dimension based on the second dimension, the rows of the calculated dimension being identical to the rows of the first dimension, application of the filter to the rows of the calculated dimension to generate filtered rows of the calculated dimension, execution of an inner join between the filtered rows of the calculated dimension and a fact table of the second data model to generate a result table including one or more measure values of the second data model, and generation of a visualization including the result table.

Abstract: A hydrocarbon injector deflector for a diesel exhaust system includes a base plate having a first end linearly extending to a second end to define a first side and a second side. The base plate is arcuately formed such that the first side extends arcuately to the second side. The first end is disposed upstream of the exhaust system relative to the second end. The hydrocarbon deflector further includes a frame connected to the second end of the base plate and extends therefrom at a first angle. The frame has an opening formed through the frame. The opening defines an outer wall having an inner side of the frame. The deflector further includes a tab extending from the inner side at a second angle.

Abstract: An aftertreatment module is disclosed for use with an engine. The aftertreatment module may have an inlet housing at least partially defining an inlet passage for exhaust, and at least one mixer disposed in the inlet passage. The aftertreatment module may also have an outlet housing at least partially defining an outlet passage for exhaust, and a catalyst housing removably connected between the inlet housing and the outlet housing. The aftertreatment module may further have a plurality of catalyst substrates configured to be mounted in the catalyst housing, to receive exhaust from the inlet passage in parallel, and to discharge exhaust to the outlet housing in parallel.

Abstract: An aftertreatment module is disclosed for use with an engine. The aftertreatment module may have an inlet housing at least partially defining an inlet passage for exhaust, and at least one mixer disposed in the inlet passage. The aftertreatment module may also have an outlet housing at least partially defining an outlet passage for exhaust, and a catalyst housing removably connected between the inlet housing and the outlet housing. The aftertreatment module may further have a plurality of catalyst substrates configured to be mounted in the catalyst housing, to receive exhaust from the inlet passage in parallel, and to discharge exhaust to the outlet housing in parallel.

Abstract: An aftertreatment module is disclosed for use with an engine. The aftertreatment module may have an inlet housing at least partially defining an inlet passage for exhaust, and at least one mixer disposed in the inlet passage. The aftertreatment module may also have an outlet housing at least partially defining an outlet passage for exhaust, and a catalyst housing removably connected between the inlet housing and the outlet housing. The aftertreatment module may further have a plurality of catalyst substrates configured to be mounted in the catalyst housing, to receive exhaust from the inlet passage in parallel, and to discharge exhaust to the outlet housing in parallel.

Abstract: An aftertreatment module is disclosed for use with an engine. The aftertreatment module may have an inlet housing at least partially defining an inlet passage for exhaust, and at least one mixer disposed in the inlet passage. The aftertreatment module may also have an outlet housing at least partially defining an outlet passage for exhaust, and a catalyst housing removably connected between the inlet housing and the outlet housing. The aftertreatment module may further have a plurality of catalyst substrates configured to be mounted in the catalyst housing, to receive exhaust from the inlet passage in parallel, and to discharge exhaust to the outlet housing in parallel.

Abstract: A mixing element positioned at an exhaust inlet of a Selective Catalytic Reduction (SCR) module is provided. The mixing element includes a base plate having a plurality of perforations thereon. The mixing element also includes a plurality of vanes connected to the base plate. Each of the plurality of vanes is spaced apart from one another. The plurality of vanes includes a plurality of flaps extending radially from the base plate. Each of the plurality of flaps has a planar configuration. The plurality of vanes also includes a plurality of blades attached to the plurality of flaps. Each of the plurality of blades extends axially with respect to an axis of the exhaust inlet. The blade has a curved configuration.

Abstract: A mixing element positioned at an exhaust inlet of a Selective Catalytic Reduction (SCR) module is provided. The mixing element includes a base plate having a plurality of perforations thereon. The mixing element also includes a plurality of vanes connected to the base plate. Each of the plurality of vanes is spaced apart from one another. The plurality of vanes includes a plurality of flaps extending radially from the base plate. Each of the plurality of flaps has a planar configuration. The plurality of vanes also includes a plurality of blades attached to the plurality of flaps. Each of the plurality of blades extends axially with respect to an axis of the exhaust inlet. The blade has a curved configuration.

Abstract: A method uses a computer and software to measure bone density and structure of the proximal femur of the hip from a volumetric set of images containing pixels representing x-ray attenuation of the subject which are acquired with three-dimensional X-ray imaging devices. The method automatically locates anatomical markers of the hip without operator interaction, automatically positions regions of interest (ROIs) for measurement, automatically determines bone density measures of the ROIs, and automatically reports the results for individual subjects. Bone density measurements of ROIs include the integral bone of the total hip and neck as well as trabecular bone. The method automatically identifies a three-dimensional region-of-interest (ROI) volume which includes the hip, determines a three-dimensional coordinate system referenced to the anatomy of the subject, analyzes the ROI volume to identify voxels in the volume which satisfy defined criteria, and determines a measure of bone structure.

Abstract: An antibacterial agent including a photocatalytic antibacterial material. The photocatalytic antibacterial material includes a rare-earth element modified tetrapod-shaped zinc oxide whisker (T-ZnOw). A method for preparation of the antibacterial agent is also provided, and includes: 1) adding a tetrapod-shaped zinc oxide whisker and a dispersant into a dispersion medium, and dispersing to yield a tetrapod-shaped zinc oxide whisker dispersion system; and 2) adding a rare-earth element to the dispersion system under ultrasound conditions, stirring, performing ultrasonic vibration, filtering, washing, drying, and baking, to yield the antibacterial agent.