Patents by Inventor Ping-Yu Wu

Ping-Yu Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11008288
    Abstract: The present invention discloses a method for preparation of Apremilast. ?-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: May 18, 2021
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Hsyueh-Liang Wu, Ping Yu Wu, Jin-Fong Syu, Julian P. Henschke
  • Patent number: 9670234
    Abstract: This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted -4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: June 6, 2017
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Julian Paul Henschke, Ping-Yu Wu, Hsyueh-Liang Wu, Wen-Hsien Wen
  • Patent number: 9328100
    Abstract: The present application discloses a stereoselective process for the preparation of ?-C-arylglucosides that does not require the use of conventional carbohydrate protecting groups. In one embodiment, the stereoselective process comprises the preparation of the compound of formula I: the process comprising: a) contacting 1,6-anhydro-?-D-glucopyranose with a compound of formula II, R1R2R3Al, in a solvent to form a first reaction mixture; b) contacting the first reaction mixture of step a) with a second reaction mixture to form a third reaction mixture, wherein the second reaction mixture is prepared by contacting an organoaluminum compound of formula III, R4aR5bAlXc, with a compound of formula IV, ArM; and c) contacting the third reaction mixture with a reagent to form the compound of the formula I.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 3, 2016
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Julian Paul Henschke, Ping-Yu Wu, Jyh-Hsiung Liao, Chen-Wei Lin
  • Publication number: 20160009740
    Abstract: This invention provides a novel method for the preparation of 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted-4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.
    Type: Application
    Filed: July 9, 2015
    Publication date: January 14, 2016
    Inventors: Julian Paul Henschke, Ping-Yu Wu, Hsyueh-Liang Wu, Wen-Hsien Wen
  • Publication number: 20150291569
    Abstract: The present application discloses a stereoselective process for the preparation of ?-C-arylglucosides that does not require the use of conventional carbohydrate protecting groups.
    Type: Application
    Filed: April 10, 2015
    Publication date: October 15, 2015
    Applicant: ScinoPharm Taiwan, Ltd.
    Inventors: Julian Paul Henschke, Ping-Yu Wu, Jyh-Hsiung Liao, Chen-Wei Lin
  • Patent number: 8952139
    Abstract: The present invention provides processes (e.g., arylation reaction) for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: February 10, 2015
    Assignee: ScinoPharm Taiwan, Ltd
    Inventors: Julian Paul Henschke, Chen-Wei Lin, Ping-Yu Wu, Chi-Nung Hsiao, Jyh-Hsiung Liao, Tsung-Yu Hsiao
  • Patent number: 8865893
    Abstract: A method for preparing 2-morpholinoisobornane-10-thiol is disclosed, which has simplified steps and avoids the use of Na metal. Accordingly, it is advantageous to apply the method in a mass production.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: October 21, 2014
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Yu-Han Tsao, Ping-Yu Wu
  • Patent number: 8859765
    Abstract: The present invention provides efficient and economical methods for synthesis of (?)-2-exo-morpholinoisoborne-10-thiol, its enantiomer, and related chiral catalysts. Novel compounds and methods of asymmetric synthesis are also disclosed.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: October 14, 2014
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Ping-Yu Wu, Julian Paul Henschke
  • Publication number: 20140128595
    Abstract: The present invention provides processes for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors.
    Type: Application
    Filed: November 7, 2012
    Publication date: May 8, 2014
    Applicant: ScinoPharm Taiwan, LTD.
    Inventors: Julian Paul Henschke, Chen-Wei Lin, Ping-Yu Wu, Chi-Nung Hsiao, Jyh-Hsiung Liao, Tsung-Yu Hsiao
  • Patent number: 8309715
    Abstract: A novel camphor-derived ?-amino alcohol compound is disclosed. The novel camphor-derived ?-amino alcohol compound can be used in asymmetric addition of organozinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, thus generating corresponding secondary alcohols in high yields and enantiomeric excess.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: November 13, 2012
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Chi-Rui Wu, Hsyueh-Liang Wu, Ping-Yu Wu
  • Patent number: 8168835
    Abstract: A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: May 1, 2012
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Ping-Yu Wu, Hsyueh-Liang Wu
  • Publication number: 20110295042
    Abstract: A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 1, 2011
    Inventors: Biing-Jiun UANG, Ping-Yu Wu, Hsyueh-Liang Wu
  • Publication number: 20110269955
    Abstract: A method for preparing 2-morpholinoisobornane-10-thiol is disclosed, which has simplified steps and avoids the use of Na metal. Accordingly, it is advantageous to apply the method in a mass production.
    Type: Application
    Filed: October 8, 2010
    Publication date: November 3, 2011
    Inventors: Biin-Jiun UANG, Yu-Han Tsao, Ping-Yu Wu