Abstract: An antenna device includes: a dielectric substrate; a first grounding face, a second grounding face and a third grounding face which are provided on a first face of the dielectric substrate and are isolated from each other; a first primary antenna and a first auxiliary antenna which are provided on the first face, cooperatively act with the first grounding face to operate at a first frequency range and are isolated from each other; a second primary antenna and a second auxiliary antenna which cooperatively act with the first grounding face to operate at a second frequency range and are isolated from each other; a third primary antenna which cooperatively acts with the second grounding face to operate at a third frequency range; and a third auxiliary antenna which cooperatively acts with the third grounding face to operate at the third frequency range.

Abstract: A method for seismic imaging of a subsurface using a full waveform inversion, FWI, includes the steps of obtaining an initial P-velocity model that describes how a seismic wave propagates through the subsurface, generating an S-velocity model based on the initial P-velocity model, generating an elastic synthetic dataset p based on the initial P-velocity model and the S-velocity model, receiving a recorded seismic dataset d of the subsurface, updating the P-velocity model based on a comparison between the synthetic dataset p and the recorded seismic dataset d, updating a reflectivity at various locations in the subsurface based on the updated P-velocity model, and generating an image of the subsurface based on the reflectivity.

Abstract: Disclosed herein are synthesis and use of covalent inhibitors selective for Transcriptional Enhancer Factor TEF-1 (TEAD1), which can be used for treatment of cancers such as glioblastoma, gastric cancer, colorectal cancer, pancreatic ductal adenocarcinoma (PDAC), and malignant pleural mesothelioma (MPM). Further disclosed herein are pharmaceutical compositions including the TEAD1 inhibitor and methods of treating cancers using the same.

Abstract: This application relates to novel bicyclic substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1? and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.

Abstract: System and techniques for vehicle operation safety model (VOSM) compliance measurement are described herein. A subject vehicle is tested in a vehicle following scenario against VOSM parameter compliance. The test measures the subject vehicle activity during phases of the following scenario in which a lead vehicle slows and produces log data and calculations that form the basis of a VOSM compliance measurement.

Abstract: A genetically engineered bacterial strain that produces N-acetylglucosamine, as well as a method of construction and use thereof. The genetically engineered bacterial strain can ferment N-acetylglucosamine under a condition of 40-50° C. Through knocking out genes for glucosamine 6-phosphate deaminase, N-acetylglucosamine-6-phosphate deacetylase and the N-acetylglucosamine transporter protein from a parental bacterium, an N-acetylglucosamine catabolism pathway is blocked. Moreover, overexpression genes for glucosamine 6-phosphate synthase and glucosamine 6-phosphate acetylase are introduced, enabling extra cellular accumulation of N-acetylglucosamine and high-temperature fermentation of N-acetylglucosamine at a temperature higher than 40° C.

Abstract: A computation offloading method includes: establishing an associated model of a terminal for computation offloading; training the associated model by taking a to-be-computed task of the terminal, an uplink communication channel gain, a sensing pulse response and an angle difference between a communication beam and a sensing beam as input, to obtain an offloading parameter of the terminal for the to-be-computed task, wherein the to-be-computed task comprises to-be-computed communication data and to-be-computed sensing data, and the offloading parameter comprises a decision for offloading a computing task and a decision for offloading radio frequency transmission power; and offloading the to-be-computed task to an edge side according to the offloading parameter.

Abstract: A fan with increased heat-removing ability and reduced noise in operation includes a hub, a baffle, a first blade layer, and a second blade layer. The first blade layer includes a plurality of first blades, and the second blade layer includes a plurality of second blades. An orthogonal projection of each of the plurality of first blades on the baffle is located between orthogonal projections of adjacent two of the plurality of second blades on the baffle. A length of the plurality of first blades is greater or less than a length of the plurality of second blades to avoid any resonance. An electronic device including the fan is also disclosed.

Abstract: A cooperative precoding method and device.

Abstract: The present disclosure provides processes for making enantiomerically pure isoxazoline compounds of formula (1), The present disclosure also provides processes for making enantiomerically pure isoxazoline compounds of formula (1) characterized by improving the enantiomeric purity of 3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]thiophene-2-carboxylic acid by crystallization.

Abstract: The present disclosure relates to the technical field of genetic engineering, in particular to a siRNA of an angiopoietin like 3 (ANGPTL3) and a use thereof. The inventor of the present disclosure targets to ANGPTL3 by designing an appropriate specific small interfering RNA sequence and a siRNA conjugate, and reduce the expression of an ANGPTL3 protein by degrading a transcript of an ANGPTL3 gene in a cell. Therefore, the siRNA provided in the present disclosure may be used to prevent and/or treat a dyslipidemia disease.

Abstract: The present disclosure provides an air conditioner defrosting control method and device, and a storage medium and an air conditioner. The control method includes: setting a target discharge temperature of a compressor and an initial opening degree of a throttle device when an air conditioner performs defrosting according to an outdoor ambient temperature when the air conditioner meets a defrosting condition and enters a defrosting mode; controlling a defrosting operation of the air conditioner according to the target discharge temperature of the compressor and the initial opening degree of the throttle device; and controlling the air conditioner to exit the defrosting mode when a temperature of an outdoor heart exchanger of the air conditioner reaches a set temperature value.

Abstract: Provided herein are reagents and methods for comprehensively enriching potential variants within targeted regions, named Amplicon Comprehensive Enrichment (ACE). The sequence variants enriched can include single nucleotide polymorphisms (SNPs), single nucleotide variants, or small insertions and deletions. Embodiments include procedures for integration with real-time polymerase chain reaction, next generation sequencing (NGS), and long-read sequencing.

Abstract: The invention provides a carbon-heated cigarette which comprises a carbon rod section, a tobacco section, a smoke extraction section and a filter section which are sequentially arranged from an upstream to a downstream. The carbon-heated cigarette can also comprise a composite paper and an outer wrapper wrapped around the outsides of the composite paper, the tobacco section, the smoke extraction section and the filter section. The composite paper is wrapped around a part of the carbon rod section and a part of or the entire tobacco section. The smoke extraction section has a cavity passing therethrough in an axial direction, and has a side wall having at least one side wall through-hole that communicates with the cavity. A wrapper through-hole is formed on the outer wrapper at a position corresponding to the side wall through-hole so as to allow the external air enter the smoke extraction section.

Abstract: A processing apparatus can include a memory device having a user space for executing user applications. The processing apparatus can further include infrastructure communication circuitry that can receive a request from a user application executing in the user space. The infrastructure communication circuitry can perform a service mesh operation, in response to the request, without a sidecar proxy. Other systems and methods are described.

Abstract: Systems and methods for space allocation for block device compression are provided. In particular, a computing device may receive an allocation request to write the compressed data, select a range list adequate for serving the allocation request from a plurality of range list, dequeue a range entry from the selected range list to allocate free space for the compressed data, and allocate the free space corresponding to the range entry to the compressed data to serve the allocation request.

Abstract: Disclosed are a pyrazolo[1,5-a]pyridine compound, a preparation method therefor and a use thereof. Also disclosed is a pharmaceutical composition containing the compound as an active ingredient or a pharmaceutically acceptable salt thereof. The present invention further relates to the use of a compound of formula (I) for treating and preventing diseases that can be treated with wild-type, gene fusion-type and mutant (including but not limited to G804 and G810) RET kinase inhibitors, including diseases or conditions mediated by an RET kinase.

Abstract: A compound represented by general formula (I) or stereoisomers thereof and pharmaceutically acceptable salts, solvates or prodrugs thereof, a preparation method therefor and a pharmaceutical composition containing the compound. An application of the compound of general formula (I) in preparation of drugs for treating and/or preventing she-mediated diseases, especially an application in preparation of drugs for treating inflammatory diseases, cardiovascular and cerebrovascular diseases, diabetes, diabetes complications, diabetes-related diseases, fibrotic diseases, neurological and mental diseases, pain, and ulcer diseases, etc.

Abstract: A microfluidic chip and a fabrication method of the microfluidic chip are provided. The microfluidic chip includes an array substrate, and a hydrophobic layer disposed on a side of the array substrate. The hydrophobic layer includes at least one through-hole, and a through-hole of the at least one through-hole penetrates through the hydrophobic layer along a direction perpendicular to a plane of the array substrate. The microfluidic chip also includes at least one hydrophilic structure. A hydrophilic structure of the at least one hydrophilic structure is disposed in the through-hole.

Abstract: A process of stabilizing the activity of an enzyme against inactivation by water weathering are provided including associating one or more polymeric moieties of a polyoxyethylene having a molecular weight of 10,000 Daltons or greater with an enzyme to form a chemically modified enzyme; and dispersing said chemically modified enzyme in a base to form a water-stabilized active coating material.