Abstract: The present disclosure provides a preparation method of a non-natural anti-human CD45RA murine chimeric antigen receptor (CAR). In the present disclosure, eukaryotic expression vectors pcDNA3.1/Mu3A4-4-1BB-3? and pcDNA3.1/Mu3A4-4-1BB-3?-EGFP and a lentiviral expression vector pLenti/Mu3A4-4-1BB-3? are constructed based on molecular biology using a mouse-derived 3A4 antibody. The lentiviral expression vector pLenti/Mu3A4-4-1BB-3? can successfully infect human T cells and effectively kill 3A4-positive target cells such as KG1a cells and Raji cells. The recognition of antigens by Mu3A4CAR does not depend on antigen presentation process and is not restricted by a major histocompatibility complex (MHC), thus overcoming tumor immune evasion to kill 3A4-positive tumor cells more effectively.

Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds, as well as methods and uses of these compounds in the treatment of diseases.

Abstract: Disclosed are a combined blade device and a combined air outlet device. The combined blade device includes a hub, diagonal flow blades, and centrifugal blades, where a first air inlet is formed outside an edge of a first end of the hub, and a first air outlet is formed outside an edge of a second end of the hub, the hub is internally provided with a centrifugal cavity, the first end of the hub is provided with a second air inlet, the first air inlet surrounds the second air inlet, the second end of the hub is provided with a second air outlet, both the second air inlet and the second air outlet are communicated with the centrifugal cavity, and the hub expands gradually in a direction from the second air inlet to the second air outlet.

Abstract: A multi-functional reconfigurable intelligence surface (MF-RIS) integrating signal reflection, refraction and amplification and energy harvesting and an application thereof are provided. The MF-RIS can support wireless signal reflection, refraction and amplification and energy harvesting on one surface, to amplify, reflect, or refract a signal through harvested energy, and further enhance effective coverage of wireless signals. When a signal model of the MF-RIS constructed in the present disclosure is applied to a multi-user wireless network, a non-convex optimization problem of jointly designing operation modes and parameters that include BS transmit beamforming, and different components and a deployment position of the MF-RIS is constructed with an objective of maximizing a sum rate (SR) of a plurality of users in an MF-RIS-assisted non-orthogonal multiple access network.

Abstract: A display device, a method for producing a display device, and a gesture recognition method are disclosed. The display device includes a display module including a base and an array substrate, a resin layer, a first electrode layer, a pixel definition layer, a light-emitting unit layer, a second electrode layer disposed opposite to the first electrode layer, and an encapsulation layer. The light-emitting unit layer is between the first electrode layer and the second electrode layer and includes a plurality of light-emitting units respectively in a plurality of openings of the pixel definition layer, and an ultrasonic sensor including the second electrode layer, a piezoelectric material layer between the first electrode layer and the pixel definition layer, and a third electrode layer between the pixel definition layer and the resin layer. The piezoelectric material layer includes a plurality of piezoelectric material units separated by the plurality of light-emitting units.

Abstract: A preparation method for a tungsten sulfide (WS2) solid lubricating film based on high power impulse magnetron sputtering (HiPIMS) is provided. The preparation method includes the following steps: step 1: depositing a metal conductive film on a surface of a WS2 target; step 2: using magnetic field sputtering to remove the metal conductive film in a target sputtering area on the surface of the WS2 target, thereby obtaining a first WS2 target; and step 3: performing the HiPIMS on the first WS2 target to obtain the WS2 solid lubricating film. The preparation method can achieve stable glow discharge of a WS2 target and use the high deposition energy of HiPIMS to prepare the WS2 solid lubricating film with high compactness and excellent wear resistance.

Abstract: A generation method for a magnetic configuration of a magnetic material includes: obtaining an initial magnetic configuration and an initial atomic configuration of the magnetic material; and randomly generating a variety of random configuration combinations; selecting one of the random configuration combinations as a target magnetic configuration and a target atomic configuration, to obtain a constraint constant and a wave function of the target magnetic configuration; determining energy, temperature and pressure, and storing them; returning to select a new random configuration combination, and repeating the above steps by using different magnetic materials; obtaining the magnetic material of a specified phase transition temperature. The present disclosure also provides and a simulation method for a magnetic configuration of a magnetic material, which can simulate the target magnetic configuration to form a magnetic configuration library and guide the synthesis of the target magnetic materials.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: A preparation method for a tungsten sulfide (WS2) solid lubricating film based on high power impulse magnetron sputtering (HiPIMS) is provided. The preparation method includes the following steps: step 1: depositing a metal conductive film on a surface of a WS2 target; step 2: using magnetic field sputtering to remove the metal conductive film in a target sputtering area on the surface of the WS2 target, thereby obtaining a first WS2 target; and step 3: performing the HiPIMS on the first WS2 target to obtain the WS2 solid lubricating film. The preparation method can achieve stable glow discharge of a WS2 target and use the high deposition energy of HiPIMS to prepare the WS2 solid lubricating film with high compactness and excellent wear resistance.

Abstract: A wear-resistant coating with a low friction coefficient of aluminum titanium nitride-tungsten disulfide (AlTiN—WS2) and a preparation method are provided. The preparation method includes: (1) performing a titanium ion cleaning on a preprocessed substrate by using a titanium ion arc target to obtain a cleaned substrate; (2) depositing a titanium transition coating on the cleaned substrate by using a multi-arc ion plating to obtain a deposited substrate; (3) depositing an aluminum titanium nitride (AlTiN) coating on the deposited substrate by using an AlTi alloy ion arc target to obtain an AlTiN coating substrate; and (4) depositing a titanium coating and a tungsten disulfide (WS2) coating by using a high power impulse magnetron sputtering (HiPIMS) to obtain the wear-resistant coating of AlTiN—WS2. The wear-resistant coating is prepared by pre-depositing the AlTiN solid coating using the multi-arc ion plating, and followed by depositing the WS2 solid lubrication coating using HiPIMS.

Abstract: The disclosure relates to a light-emitting diode, which includes a semiconductor stacked structure, a channel, a first electrode, and a second electrode. The channel surrounds the semiconductor stacked structure. When viewed from above the light-emitting diode toward the semiconductor stacked structure, the semiconductor stacked structure has at least one chamfered portion located in the channel, and a range of a radius of curvature of the chamfered portion is from 5 to 50 microns. Through the optimization of the morphology of the LED chip epitaxial layer edges in the intersection region of the channel, the damage to the epitaxial layer caused by laser energy during stealth dicing is reduced, thereby achieving the objective of enhancing chip reliability.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: Provided is a wearable display device. The wearable display device includes a display panel, comprising a display region and a peripheral region surrounding the display region; a plurality of light-emitting elements, configured to emit light to be irradiated to eyes of a user; a lens assembly, disposed on a light-exiting side of the display panel, the lens assembly comprising a lens mount and a lens within the lens mount, a light transmittance of the lens mount being greater than a threshold; and a plurality of photoelectric sensor assemblies in the peripheral region.

Abstract: Disclosed herein are methods of preparing a composite, comprising mixing a solid elastomer, a wet filler, and a resin. Single-stage or multi-stage mixing methods can be used. Also disclosed are composite comprising the filler dispersed in the elastomer at a loading of at least 20 phr, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: The combined fan blade structure includes: an inner hub, an outer hub, a first blade set, and a second blade set. The outer hub and the inner hub are coaxially arranged, the first blade set is connected to an outer peripheral surface of the outer hub, the second blade set is located between the inner hub and the outer hub, and the outer hub blocks the second blade set.