Abstract: The present invention relates to substituted nitrogen-containing heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using any of these derivatives and compositions for H4 receptor activity modulation and the treatment of states mediated by histamine H4 receptor activity.

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract: The invention relates to a PCB blank comprising a protective film which is resistant to acid and which is made of at least two layers which are chemically linked to each other underneath each other and/or are linked to the metal surface of the PCB blank. The invention also relates to a method for coating a PCB blank with a protective film which is resistant to acid and which is made of at least two layers.

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract: Quinazolines of the formula I in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent Claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

Abstract: A compact interrogator for the simultaneous interrogation of multi wavelength-modulated fiber optical sensors, includes a planar waveguide based demultiplexer receiving input signals from the sensors. An array of detectors is coupled to output waveguides of the demultiplexer corresponding to different nominal wavelengths. A tuning element matches the nominal wavelengths of the output waveguide to the input signals from the respective sensors to find the wavelengths of the individual sensors to be interrogated.

Abstract: A method for reducing expression of a target gene in a mammalian cell is provided. The method comprises (a) introducing siRNA into a first mammalian cell such that expression of the target gene is reduced in the first mammalian cell, and (b) exposing a second mammalian cell which does not contain siRNA that reduces expression of the target gene to the siRNA-containing first mammalian cell, thereby resulting in reduced expression of the target gene in the second mammalian cell. An additional aspect provides a method of reducing expression of a target gene in a mammal. Yet another aspect provides a mammalian cell transfected with an expression vector which directs expression of siRNA for a target gene such that expression of the target gene is reduced in the transfected mammalian cell, and the siRNA expression level is sufficient to signal reduction of target gene expression in a mammalian cell not transfected with siRNA for the target gene.

Abstract: The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: where R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

Abstract: Quinazolinones of formula (I) in which R, R1, R2, R3, R4, Y, n and m have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists

Abstract: A compact interrogator for the simultaneous interrogation of multi wavelength-modulated fiber optical sensors, includes a planar waveguide based demultiplexer receiving input signals from the sensors. An array of detectors is coupled to output waveguides of the demultiplexer corresponding to different nominal wavelengths. A tuning element matches the nominal wavelengths of the output waveguide to the input signals from the respective sensors to find the wavelengths of the individual sensors to be interrogated.

Abstract: Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.

Abstract: One embodiment of the present invention is a servo writing device comprising: (a) a servo track writer assembly that is adapted to write servo tracks; (b) a base that is adapted to support the servo track writer assembly; and (c) an adhesive damping layer that that is: (i) disposed between the servo track writer assembly and the base; and (ii) adapted to connect the servo track writer assembly and the base.

Abstract: Quinazolines of the formula I, in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

Abstract: Disclosed are compounds of formula (I): 1

Abstract: A method for analyzing large data arrays is provided. In one aspect, the invention provides a method for analyzing data from two or more data arrays. Each array includes a plurality of members, each member provides a signal, and the data is indexed by one or more parameters. In one embodiment, the method includes fitting a model to the data; determining the goodness of the fit by evaluating the statistical significance of the fit; and determining the statistical significance of the signal. In another embodiment, the method further includes correcting the data for heterogeneity among members prior to fitting the model to the data.

Abstract: Disclosed are compounds of formula (I): 1

Abstract: A magnetic rotational position sensor comprises a loop pole piece, at least one magnet, and at least one magnetic flux sensitive transducer. The magnet is disposed within an air gap of the loop pole piece to establish a magnetic field through the air gap and to enclose magnetic flux within the loop pole piece. A control shaft is rotatable about a first axis and the loop pole piece and the magnet are adjoined to the control shaft to synchronously rotate the magnetic field about a second axis. A working air gap area is defined within the air gap area of the loop pole piece between a pole surface of the magnet and an inner surface of the loop pole piece. A magnetic flux sensitive transducer is disposed within the air gap to sense a magnitude of magnetic flux density.