Abstract: Provided in the present disclosure are a pharmaceutically acceptable salt of an epidermal growth factor receptor (EGFR) inhibitor, a crystal form thereof, a preparation method therefor and an application thereof. The structural formula of the EGFR inhibitor is as shown in formula I, and the pharmaceutically acceptable salt is a mesylate, p-toluenesulfonate, phosphate, hydrochloride or citrate salt of the EGFR inhibitor. The pharmaceutically acceptable salt of EGFR inhibitor of the present disclosure has a specific crystal form, has a higher solubility and stability than a corresponding free base, is more suitable for preparing drugs for use in treating cancer (especially non-small cell lung cancer), and satisfies the requirements for bioavailability and drug efficacy.

Abstract: One embodiment of the present invention provides a system for a fine-grained power management. The system receives, by a first server, a task assigned based on a global power state, wherein the first server includes one or more drives, a drive includes one or more channels, and a channel includes one or more integrated circuits. The system places an inactive drive into a power-saving mode. The system places an inactive channel of an active drive into the power-saving mode by using a power switch associated with each integrated circuit in the inactive channel. The system places an inactive integrated circuit of an active channel into the power-saving mode by using a power switch associated with the inactive integrated circuit. The system updates a data structure storing the global power state based on a current power state of the first server, the drives, the channels, and the integrated circuits.

Abstract: An automatic handle assembly system for a paint brush, including a feeding device, a conveying device, a handle pushing device, a pneumatic system, and a control system. The feeding device is used for transporting a glue-filled paint brush head to an entrance of the conveying device. The conveying device is used for realizing transportation, pressing and precise positioning of the paint brush head. The handle pushing device is used for pushing a paint brush handle to precisely insert into the paint brush head. The feeding device, the conveying device, and the handle pushing device are all connected to the pneumatic system and the control system.

Abstract: This application provides a data transmission method, user equipment, and a base station. The method is applied to a scheduling-free scenario of the base station for the user equipment UE, and the method includes: determining, by the UE, a target resource group from a plurality of transmission resource groups; and sending, by the UE, data to the base station by using a transmission resource in the target resource group, so that the base station performs data processing on the data by using a transmission format corresponding to the target resource group.

Abstract: Systems and methods are provided for constructing a physical system. Characteristic data associated with a physical system is received. A model of the physical system is built based on the characteristic data. A nonlinear transient simulation of the physical system is performed using the model, where the simulation is performed over a plurality of time intervals. The simulation includes segmenting the plurality of time intervals into groups of time intervals, each group containing multiple time intervals, transmitting data associated with each group of time intervals to a different solving unit, and solving each of the groups of time intervals in parallel using the different solving units. A physical characteristic is determined based on results of the simulation, where the physical system is built or modified based on the simulation-determined physical characteristic.

Abstract: Using persistent memory for key-value storage is disclosed, including: receiving a put key operation including a key and a corresponding value; directly storing the key at a persistent memory media using a physical address that is determined based at least in part on the key, wherein the persistent memory media supports memory persistence and in-place updating; directly storing the value to the persistent memory media; receiving a get key operation including the key; and directly accessing the persistent memory media using the physical address that is determined based at least in part on the key to retrieve the value corresponding to the key.

Abstract: One embodiment facilitates data destruction in a phase change memory-based storage device. During operation, the system detects, by the storage device, a power loss. Subsequent to the power loss, the system overwrites keys and configuration information used to transform data stored in the phase change memory, wherein the keys and the configuration information are stored in the phase change memory, thereby preventing the data from being recovered.

Abstract: One embodiment facilitates an active persistent memory. During operation, the system receives, by a non-volatile memory of a storage device via a memory bus, a command to manipulate data on the non-volatile memory, wherein the memory bus is connected to a volatile memory. The system executes, by a controller of the non-volatile memory, the command.

Abstract: Methods, systems, and devices for wireless communication are described. A user equipment (UE) may be enabled for voice over long term evolution (VoLTE). The UE may include an audio layer to encode and decode voice information and a packet layer to transmit voice packets. The packet layer may store parameters related to a discontinuous reception (DRX) in a shared memory. The audio layer may obtain the DRX parameters and encode voice information based on the parameters. For example, the audio layer coding may be synchronized with the wake period of the DRX cycle. The audio layer may encode voice information during a wake up period of the packet layer DRX cycle, and the packet layer may transmit the voice packets while awake. The audio layer may perform back to back encodings at the beginning of the DRX cycle. The packet layer may extend the wake period to transmit the voice packets.

Abstract: One embodiment facilitates mitigating write amplification in a phase change memory-based storage device. During operation, the system receives, by a controller of the storage device, data to be stored in a phase change memory (PCM) of the storage device. The system writes, by the controller, the data to a sector of a volatile memory of the same storage device to obtain an updated portion of the sector. In response to detecting a predetermined condition, the system writes the updated portion to the PCM.

Abstract: One embodiment of the present invention provides a system for a fine-grained power management. The system receives, by a first server, a task assigned based on a global power state, wherein the first server includes one or more drives, a drive includes one or more channels, and a channel includes one or more integrated circuits. The system places an inactive drive into a power-saving mode. The system places an inactive channel of an active drive into the power-saving mode by using a power switch associated with each integrated circuit in the inactive channel. The system places an inactive integrated circuit of an active channel into the power-saving mode by using a power switch associated with the inactive integrated circuit. The system updates a data structure storing the global power state based on a current power state of the first server, the drives, the channels, and the integrated circuits.

Abstract: One embodiment described herein provides a data storage system. The storage system includes a communication interface for receiving a write command from a host of the data storage system and a first write cache coupled to the host via the communication interface. The write command includes to-be-written data and address information associated with the to-be-written data. The first write cache is configured to temporarily store the to-be-written data before sending the to-be-written data to a high-capacity storage device coupled to the host, and the first write cache is configured to update its content by performing byte-level in-place writing based on the received write command.

Abstract: The invention provides a B-stageable adhesive composition, based on the total weight of the adhesive composition, comprising: 13-59 wt % of an epoxy resin; 18-69 wt % of a carboxyl terminated butadiene-acrylonitrile copolymer; and 3-34 wt % of a polyterpene modified phenol-formaldehyde resin. Additionally, the B-stageable adhesive composition may further comprise a hardener, an inorganic filler including a flame retardant agent, a thermal conductive filler or the like. According to the disclosure of the application, a new B-stageable adhesive composition having a high tackiness, a high temperature resistance, a high flame resistance and a high thermal conductivity can be provided.

Abstract: Resource management includes: operating in a first mode, including executing a controller operation in connection with a plurality of local elements, wherein the controller operation is executed by a configurable resource; switching from the first mode to a second mode; and operating in the second mode, including: executing a data processing task in a first portion of the configurable resource; and executing the controller operation in connection with the plurality of local elements, in a second portion of the configurable resource.

Abstract: MyD88 inhibitor can be used to prevent, for example, post myocardial infarction ischemia reperfusion injury, post severed limb replantation ischemia reperfusion injury and post transplantation ischemia reperfusion injury, and to play important role in production of organ preservation solution, cell preservation solution etc. Furthermore, results of in vitro experiment show that MyD88 inhibitor TJM2010-5 can effectively reduce the level of inflammatory factors in graft through inhibiting the pathway, which means that it is closely related to the generation of inflammatory factors, therefore, the TJM2010-5 can become the effective method for treating of various inflammations, prevent the vicious circle and vicious transformation of chronic inflammation, and prevent and treat inflammatory cancerization etc.

Abstract: Using persistent memory for key-value storage is disclosed, including: receiving a put key operation including a key and a corresponding value; directly storing the key at a persistent memory media using a physical address that is determined based at least in part on the key, wherein the persistent memory media supports memory persistence and in-place updating; directly storing the value to the persistent memory media; receiving a get key operation including the key; and directly accessing the persistent memory media using the physical address that is determined based at least in part on the key to retrieve the value corresponding to the key.

Abstract: The present invention provides compositions and methods to treat Alzheimer's disease and other neurodegenerative diseases and conditions by expressing exogenous prohibitin in the neurons of the brain of the subject.

Abstract: The present disclosure relates to a B-stageable adhesive composition and an article prepared by the same. In the present disclosure, the adhesive composition comprises the following components in solid content percentage: (A) 10% to 50% by weight of a first epoxy resin with a weight average molecular weight Mw of 8,000 g/mol or more; (B) 5% to 20% by weight of a second epoxy resin with a weight average molecular weight Mw of 200 to 6,000 g/mol; (C) 30% to 80% by weight of a hydroxyl terminated polyester or derivates thereof; (D) 0.1% to 2.5% by weight of a first curing agent capable of reacting with epoxy group; and (E) 0.1% to 2.5% by weight of a second curing agent capable of reacting with hydroxyl group; the sum of components of the composition is equal to 100% by weight. The coating obtained from the adhesive composition of the present disclosure shows high adhesive strength, excellent heat resistance and flame retardance.

Abstract: The present disclosure relates to a B-stageable adhesive composition and a coating prepared by the same. In the present disclosure, the adhesive composition comprises the following components in solid content percentage: (A) 15% to 50% by weight of a first epoxy resin with a weight average molecular weight Mw of 8,000 g/mol or more; (B) 3% to 15% by weight of a second epoxy resin with a weight average molecular weight Mw of 200 to 2,000 g/mol; (C) 20% to 50% by weight of a carboxyl terminated polyester or derivates thereof; (D) 0.1% to 2.5% by weight of a first curing agent capable of reacting with epoxy group; (E) 0.1% to 2.5% by weight of a second curing agent capable of reacting with carboxyl group; and (F) 0% to 40% by weight of a flame retardant. The coating obtained from the adhesive composition of the present disclosure shows good adhesion strength, heat resistance and functional properties such as flame retardance and prolonged shelf life.

Abstract: The invention provides a device and the use thereof in a cell experiment in vitro. This device has a polydopamine layer-carboxymethyl chitosan layer-peptide layer structure, which is capable of regulating behaviors of human pluripotent stem cells and is useful in cell culture or a cell experiment in vitro.