Abstract: The present disclosure relates to methods and devices for testing video data being rendered at or using a media device. A plurality of video frames to be rendered is received, each frame comprising one or more primary screen objects and at least one further screen object. The received frames are rendered at or using the media device wherein the at least one further screen object is superimposed on the one or more primary screen objects of a given frame during rendering. The rendered frames are provided to a data model. Extracted metadata indicating the presence or absence of further screen objects in the rendered video frames is the output of the data model. The data model is also provided with original metadata associated with the video frames prior to rendering. The rendering of each further screen object is then tested based on the original metadata and extracted metadata relating to a given video frame.

Abstract: The present invention discloses a pharmaceutical composition and a brexpiprazole oral soluble film. The pharmaceutical composition comprises brexpiprazole, a film-forming material and a plasticizer, wherein D90 of brexpiprazole is: 25 ?m?D90?50 ?m. The pharmaceutical composition provided by the present invention can achieve a better dissolution rate with the same efficacy and safety as the reference tablet. Meanwhile, the brexpiprazole oral soluble film provided by the present invention has the advantages of improving the uniformity of API content, controllable dissolution rate, simple preparation process and simple preparation materials.

Abstract: Disclosed are a pharmaceutical composition, an aprepitant injection, and an aprepitant freeze-dried powder injection. The pharmaceutical composition comprises aprepitant, a primary stabilizer, and a secondary stabilizer, wherein the primary stabilizer comprises sodium deoxycholate and the secondary stabilizer comprises povidone. The aprepitant injection can be administered by injecting. The formulation uses a largely reduced amount of excipients, and is less irritative to an injection site, less prone to cause a hypersensitive reaction, and thus safer when being used by a patient. The formulation has good stability and can be stored and transported at room temperature, largely reducing production, storage, and transportation costs.

Abstract: A method and system provide for searching a computer-aided design (CAD) drawing. A CAD drawing is obtained and includes vector based geometric entities. For each entity, primitives are extracted. A feature coordinate system is created for each of the entities using the primitives. The primitives are transformed from a world coordinate system to feature coordinates of a feature coordinate system. Geometry data of the transformed entities is encoded into index codes that are utilized in an index table as keys. A target geometric entity is identified and a target index code is determined and used to query the index table to identify instances of the target geometric entity in the CAD drawing.

Abstract: A related substance of linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline, 4,4?-(2-methylpropane-1,3-diyl)bis(2-(chloromethyl)quinazoline) and a method for synthesizing the related substance (impurity) by reacting 2-(chloromethyl)-4-methylquinazoline with acetaldehyde under an alkaline condition and a purification method are provided. The preparation method is simple and convenient to operate, short in reaction time, high in product purity, and high in yield. The synthesized related substance can be used for qualitative and quantitative analysis of the linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline and API impurities of linagliptin, so that the medication safety of the linagliptin is improved.

Abstract: Systems and methods for computing with multiple nodes. In some embodiments, the method includes: determining that a first data value in a cache is a global data value; setting a first flag to indicate that the first data value is a global data value; and selectively invalidating one or more portions of the cache, wherein the selective invalidating of the cache includes: determining, based on the first flag, that the first data value is a global data value; and based on the determining, invalidating the first data value.

Abstract: A data restoration method and a related device are provided. To avoid a data loss in a cache in a process of restoring an offline RAID system, a security area is configured in a disk, where the security area is used to back up data in the cache of a RAID controller after the RAID system is offline. Therefore, when a first instruction used to indicate that the RAID system is offline is obtained, the data in the cache may be backed up to the security area. In this way, after the RAID system is restored, the RAID system can obtain backup data of the data in the cache from the security area, to avoid problems such as an operating system startup failure or a user data loss caused by the data loss in the cache.

Abstract: A method and system provide for searching a computer-aided design (CAD) drawing. A CAD drawing is obtained and includes vector based geometric entities. For each entity, primitives are extracted and held in a graph with graph nodes that record entity paths. A feature coordinate system is created for each of the entities using the primitives. The primitives are transformed from a world coordinate system to feature coordinates of the feature coordinate system. Geometry data of the transformed entities is encoded into index codes that are utilized in an index table as keys with the graph nodes as values. A target geometric entity is identified and a target index code is determined and used to query the index table to identify instances of the target geometric entity in the CAD drawing. Found instances in the CAD drawing are displayed in a visually distinguishable manner.

Abstract: The present disclosure relates to synthesis of an mRNA delivery agent, in particular to a reaction of a related amino compound with ethylene oxide in the presence of ytterbium triflate.

Abstract: A method and system is provided. The method and system enable content to be filtered intelligently to remove content which is not likely to be of interest to a user.

Abstract: The present disclosure relates to methods and devices for testing video data being rendered at or using a media device. A plurality of video frames to be rendered is received, each frame comprising one or more primary screen objects and at least one further screen object. The received frames are rendered at or using the media device wherein the at least one further screen object is superimposed on the one or more primary screen objects of a given frame during rendering. The rendered frames are provided to a data model. Extracted metadata indicating the presence or absence of further screen objects in the rendered video frames is the output of the data model. The data model is also provided with original metadata associated with the video frames prior to rendering. The rendering of each further screen object is then tested based on the original metadata and extracted metadata relating to a given video frame.

Abstract: A preparation method of an intermediate compound of formula II ((1R,2S,3S,4S,5S,6R,11S,14S,17S,19R,21R,23S,25R,26R,27S,31R,34S)-25-[(2S)-2,3-dihydroxy]-2,5-dihydroxy-26-methoxy-19-methyl-13,20-dimethylene-24,35,36,37,38,39-hexaoxane[29.3.1.13,6.14,34.111,14.117,21.023,27]nonatriacontan-8,29-dione) for eribulin mesylate is provided, including subjecting a compound of formula I to a reaction with an additive in the presence of tetra-n-butylammonium fluoride (TBAF). The additive is piperidine hydrochloride or pyridine hydrochloride, and a reaction formula is as follows: The present invention aims to avoid the problem that a traditional synthetic route has a low yield.

Abstract: A method and system provide for searching a computer-aided design (CAD) drawing. A CAD drawing is obtained and includes vector based geometric entities. For each entity, primitives are extracted and held in a graph with graph nodes that record entity paths. A feature coordinate system is created for each of the entities using the primitives. The primitives are transformed from a world coordinate system to feature coordinates of the feature coordinate system. Geometry data of the transformed entities is encoded into index codes that are utilized in an index table as keys with the graph nodes as values. A target geometric entity is identified and a target index code is determined and used to query the index table to identify instances of the target geometric entity in the CAD drawing. Found instances in the CAD drawing are displayed in a visually distinguishable manner.

Abstract: The present disclosure relates to methods and devices for testing video data being rendered at or using a media device. A plurality of video frames to be rendered is received, each frame comprising one or more primary screen objects and at least one further screen object. The received frames are rendered at or using the media device wherein the at least one further screen object is superimposed on the one or more primary screen objects of a given frame during rendering. The rendered frames are provided to a data model. Extracted metadata indicating the presence or absence of further screen objects in the rendered video frames is the output of the data model. The data model is also provided with original metadata associated with the video frames prior to rendering. The rendering of each further screen object is then tested based on the original metadata and extracted metadata relating to a given video frame.

Abstract: A more environmentally friendly synthesis method of 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene with simplified steps provides a more effective synthetic strategy for producing key intermediates of SGLT-2 inhibitors such as dapagliflozin, sotagliflozin, and ertugliflozin. In the presence of trifluoroacetic anhydride, 5-bromo-2-chlorobenzoic acid and phenetole are selected to complete a direct acylation reaction under the catalysis of boron trifluoride diethyl etherate, and triethylsilane is added thereinto without treatment for one-pot reaction to obtain a target compound 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene.

Abstract: A related substance of linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline, 4,4?-(2-methylpropane-1,3-diyl)bis(2-(chloromethyl)quinazoline) and a method for synthesizing the related substance (impurity) by reacting 2-(chloromethyl)-4-methylquinazoline with acetaldehyde under an alkaline condition and a purification method are provided. The preparation method is simple and convenient to operate, short in reaction time, high in product purity, and high in yield. The synthesized related substance can be used for qualitative and quantitative analysis of the linagliptin intermediate 2-(chloromethyl)-4-methylquinazoline and API impurities of linagliptin, so that the medication safety of the linagliptin is improved.

Abstract: A preparation method of an intermediate compound of formula II ((1R,2S,3S,4S,5S,6R,11S,14S,17S,19R,21R,23S,25R,26R,27S,31R,34S)-25-[(2S)-2,3-dihydroxy]-2,5-di hydroxy-26-methoxy-19-methyl-13,20-dimethylene-24,35,36,37,38,39-hexaoxane[29.3.1.13,6.14,34.111,14.117,21.023,27]nonatriacontan-8,29-dione) for eribulin mesylate is provided, including subjecting a compound of formula I to a reaction with an additive in the presence of tetra-n-butylammonium fluoride (TBAF). The additive is piperidine hydrochloride or pyridine hydrochloride, and a reaction formula is as follows: The present invention aims to avoid the problem that a traditional synthetic route has a low yield.

Abstract: An embodiment of an integrated circuit comprises circuitry to generate a cache tag for data to be stored in a cache memory, store a first portion of the cache tag in a primary tag memory, and store a second portion of the cache tag in a secondary tag memory, wherein a size of the first portion is smaller than a size of the second portion. Other embodiments are disclosed and claimed.

Abstract: A data restoration method and a related device are provided. To avoid a data loss in a cache in a process of restoring an offline RAID system, a security area is configured in a disk, where the security area is used to back up data in the cache of a RAID controller after the RAID system is offline. Therefore, when a first instruction used to indicate that the RAID system is offline is obtained, the data in the cache may be backed up to the security area. In this way, after the RAID system is restored, the RAID system can obtain backup data of the data in the cache from the security area, to avoid problems such as an operating system startup failure or a user data loss caused by the data loss in the cache.

Abstract: A more environmentally friendly synthesis method of 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene with simplified steps provides a more effective synthetic strategy for producing key intermediates of SGLT-2 inhibitors such as dapagliflozin, sotagliflozin, and ertugliflozin. In the presence of trifluoroacetic anhydride, 5-bromo-2-chlorobenzoic acid and phenetole are selected to complete a direct acylation reaction under the catalysis of boron trifluoride diethyl etherate, and triethylsilane is added thereinto without treatment for one-pot reaction to obtain a target compound 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene.