Patents by Inventor Pingkai Ouyang
Pingkai Ouyang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11920017Abstract: A method of a polyurethane foam includes the following steps of: (1) simultaneously pumping a mixed solution prepared from hydrogen peroxide, an organic acid, a catalyst and a stabilizer and a vegetable oil into a first microstructured reactor of a micro-channel modular reaction device for reacting to obtain a reaction solution containing epoxidized vegetable oil; (2) simultaneously pumping the reaction solution containing the epoxidized vegetable oil obtained from the step (1) and a compound of formula III into a second microstructured reactor of the micro-channel modular reaction device for reaction to obtain a vegetable oil polyol; and (3) reacting the vegetable oil polyol prepared from the step (2) with a foam stabilizer, a cyclohexylamine, an isocyanate and a foaming agent cyclopentane for foaming so as to prepare a rigid polyurethane foam.Type: GrantFiled: April 12, 2021Date of Patent: March 5, 2024Assignee: NANJING TECH UNIVERSITYInventors: Kai Guo, Zheng Fang, Chengkou Liu, Ning Zhu, Jingjing Meng, Junjie Tao, Xin Hu, Xin Li, Chuanhong Qiu, Pingkai Ouyang
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Patent number: 11912814Abstract: A preparation method of a flexible polyurethane foam includes the following steps of: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain a vegetable oil polyol for flexible polyurethane foam; and (3) using the vegetable oil polyol for flexible polyurethane foam obtained in the step (2) as the unique polyol, and subjecting the same and an isocyanate polyol to a foaming reaction to obtain the flexible polyurethane foam.Type: GrantFiled: April 12, 2021Date of Patent: February 27, 2024Assignee: NANJING TECH UNIVERSITYInventors: Kai Guo, Zheng Fang, Junjie Tao, Wei He, Chengkou Liu, Jindian Duan, Xin Li, Ning Zhu, Jiangkai Qiu, Shiyu Guo, Pingkai Ouyang
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Patent number: 11814516Abstract: The invention belongs to the field of rubber tire processing, and particularly discloses an application of a lignin in preparing a radial tire, wherein the lignin is capable of completely or partially replacing resorcinol, and meanwhile, the lignin is also capable of completely or partially replacing an anti-aging agent. Compared with the prior art, the resorcinol is replaced or partially replaced by a biomass-derived lignin or a modified lignin in the invention, so that requirements of cost reduction, environmental protection and no toxicity are satisfied. Especially, the lignin modified by demethylation according to the invention is capable of effectively enhancing various properties of rubber.Type: GrantFiled: July 5, 2021Date of Patent: November 14, 2023Assignee: NANJING TECH UNIVERSITYInventors: Chenjie Zhu, Hanjie Ying, Ming Li, Pingkai Ouyang, Jiannong Shen, Xinjian Xu, Wei Zhuang, Tao Shen
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Publication number: 20230135725Abstract: A modified lignin reinforced rubber is obtained by subjecting a lignin to composite modification by a compound containing a carbon-carbon double bond, a compound containing a sulfur element and a compound capable of blocking a hydroxyl; the lignin is modified with the compound containing the carbon-carbon double bond, and the contained double bond and an olefin in the rubber generate a bonding effect, which improves a binding force between the lignin and the rubber; furthermore, by modifying the lignin with the compound containing the sulfur element, the lignin contains a certain amount of the element sulfur, which improves an interaction between the lignin and the rubber, improves properties of the rubber, and reduces the use of a vulcanizing agent, and further increases a replacement amount of the lignin to carbon black.Type: ApplicationFiled: March 24, 2021Publication date: May 4, 2023Inventors: Chenjie ZHU, Xinjian XU, Hanjie YING, Ming LI, Wei ZHUANG, Pingkai OUYANG, Tao SHEN, Junqiang SHAN
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Patent number: 11535708Abstract: A method for preparing a polyol comprises the following steps of: (1) dissolving 2,3 -epoxybutane and an acid catalyst in an inert solvent to obtain a solution A; dissolving triethylene glycol in an inert solvent to obtain a solution B; and dissolving epoxy vegetable oil in an inert solvent to obtain a solution C; (2) respectively and simultaneously pumping the solutions A and B into a first micromixer for mixing; (3) pumping the solution C and an effluent of the first microreactor into a second micromixer for mixing while carrying out step (2); and (4) dissolving the vegetable oil polyol in an inert solvent to obtain a solution D; dissolving epoxypropane and an alkaline catalyst in an inert solvent to obtain a solution E; and pumping the solution D and the solution E into a tank reactor for reaction, thereby obtaining the polyol.Type: GrantFiled: August 21, 2020Date of Patent: December 27, 2022Assignee: NANJING TECH UNIVERSITYInventors: Kai Guo, Zheng Fang, Man Yang, Junjie Tao, Ning Zhu, Wei He, Kequan Chen, Pingkai Ouyang
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Patent number: 11319339Abstract: Disclosed is a multi-channel peptide synthesizer, including a gas-bath thermotank, a plurality of reactor tubes, a motor, a rotating rack, a liquid-feeding tube, a feeding device, a vacuum tube and a nitrogen tube. The gas-bath thermotank body provides a desired constant temperature for reaction. The reactor tube provides a place for peptide synthesis and resin washing. The motor and the rotating rack are used to fully mix the reaction and cleaning solutions. Various liquid reagents required are fed to the reactor tube through the liquid-adding tube. Various materials required are prepared in advance in the feeding device and directly fed to the reactor tube. The reaction or washing solution in the reactor tube is pumped to a waste liquid tank through the vacuum tube. Nitrogen is introduced into each reactor tube through the nitrogen tube. This device can be applied in batch-wise peptide synthesis using solid-phase methods.Type: GrantFiled: June 12, 2019Date of Patent: May 3, 2022Assignee: HUNAN UNIVERSITY OF SCIENCE AND ENGINEERINGInventors: Xiaofang Luo, Yulu Gong, Zuodong Qin, Zongcheng Wang, Pingkai Ouyang
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Patent number: 11214584Abstract: It discloses a polyether polyols for preparing flexible polyurethane foam, and a preparation method and application thereof. The method comprises the following steps: (1) carrying out a reaction on phosphorus oxychloride, epichlorohydrin, a first acidic catalyst and an inert solvent in a first microchannel reactor to obtain a chloroalkoxy phosphorus compound; (2) carrying out a reaction on the chloroalkoxy phosphorus compound, glycidol, a second acidic catalyst and an inert solvent in a second microchannel reactor to obtain a hydroxy compound; (3) carrying out a ring-opening reaction on the hydroxy compound, epoxy vegetable oil, a basic catalyst and an inert solvent in a third microchannel reactor to obtain a vegetable oil polyol; and (4) carrying out an addition polymerization reaction on the vegetable oil polyol, propylene oxide and an inert solvent in a fourth microchannel reactor to obtain the polyether polyols for preparing flexible polyurethane foam.Type: GrantFiled: December 1, 2020Date of Patent: January 4, 2022Assignee: NANJING TECH UNIVERSITYInventors: Kai Guo, Zheng Fang, Wei He, Ning Zhu, Xin Hu, Jiangkai Qiu, Chengkou Liu, Jingjing Meng, Jindian Duan, Pingkai Ouyang
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Publication number: 20210332222Abstract: The invention belongs to the field of rubber tire processing, and particularly discloses an application of a lignin in preparing a radial tire, wherein the lignin is capable of completely or partially replacing resorcinol, and meanwhile, the lignin is also capable of completely or partially replacing an anti-aging agent. Compared with the prior art, the resorcinol is replaced or partially replaced by a biomass-derived lignin or a modified lignin in the invention, so that requirements of cost reduction, environmental protection and no toxicity are satisfied. Especially, the lignin modified by demethylation according to the invention is capable of effectively enhancing various properties of rubber.Type: ApplicationFiled: July 5, 2021Publication date: October 28, 2021Inventors: Chenjie ZHU, Hanjie YING, Ming LI, Pingkai OUYANG, Jiannong SHEN, Xinjian XU, Wei ZHUANG, Tao SHEN
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Patent number: 11118171Abstract: The invention discloses a recombinant Corynebacterium glutamicum for producing lysine by biofilm continuous fermentation and a construction method thereof, wherein the recombinant Corynebacterium glutamicum is constructed by overexpressing a protease gene FtsH in a Corynebacterium glutamicum; and the construction method comprises the following steps of: (1) performing PCR on a genome of the Corynebacterium glutamicum, and amplifying the FtsH gene to obtain an amplified FtsH gene segment; (2) cloning the FtsH gene segment to an overexpression plasmid to obtain a recombinant plasmid; and (3) introducing the recombinant plasmid into the Corynebacterium glutamicum, and screening to obtain the recombinant Corynebacterium glutamicum.Type: GrantFiled: December 10, 2020Date of Patent: September 14, 2021Assignee: Nanjing Tech UniversityInventors: Hanjie Ying, Dong Liu, Yong Chen, Qingguo Liu, Pingkai Ouyang, Ming Lei, Huanqing Niu, Bin Yu, Di Zhang, Yuhan Yang, Shishi Wu
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Patent number: 11098331Abstract: The invention discloses a method for producing lysine by utilizing adsorption and immobilized fermentation of a recombinant Corynebacterium glutamicum, wherein the recombinant Corynebacterium glutamicum is constructed by simultaneously overexpressing an adenosine triphosphate ATPase while knocking out an extracellular nuclease ExeR in a Corynebacterium glutamicum. The recombinant Corynebacterium glutamicum can effectively improve eDNA secretion of the Corynebacterium glutamicum and reduce eDNA degradation of the Corynebacterium glutamicum, so that the Corynebacterium glutamicum can be more easily adsorbed on a surface of a solid carrier for immobilized fermentation, such that a yield of continuous immobilized fermentation of the Corynebacterium glutamicum is increased by 49.67% than that of free fermentation of an original bacterium, and a fermentation cycle is shortened by 29.17%.Type: GrantFiled: December 10, 2020Date of Patent: August 24, 2021Assignee: Nanjing Tech UniversityInventors: Hanjie Ying, Dong Liu, Yong Chen, Pingkai Ouyang, Qingguo Liu, Huanqing Niu, Bin Yu, Xiwei Peng, Ming Lei, Xingyuan Cao
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Publication number: 20210230350Abstract: A preparation method of a flexible polyurethane foam includes the following steps of: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain a vegetable oil polyol for flexible polyurethane foam; and (3) using the vegetable oil polyol for flexible polyurethane foam obtained in the step (2) as the unique polyol, and subjecting the same and an isocyanate polyol to a foaming reaction to obtain the flexible polyurethane foam.Type: ApplicationFiled: April 12, 2021Publication date: July 29, 2021Inventors: Kai GUO, Zheng FANG, Junjie TAO, Wei He, Chengkou LIU, Jindian DUAN, Xin LI, Ning ZHU, Jiangkai QIU, Shiyu GUO, Pingkai OUYANG
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Publication number: 20210230390Abstract: A method of a polyurethane foam includes the following steps of: (1) simultaneously pumping a mixed solution prepared from hydrogen peroxide, an organic acid, a catalyst and a stabilizer and a vegetable oil into a first microstructured reactor of a micro-channel modular reaction device for reacting to obtain a reaction solution containing epoxidized vegetable oil; (2) simultaneously pumping the reaction solution containing the epoxidized vegetable oil obtained from the step (1) and a compound of formula III into a second microstructured reactor of the micro-channel modular reaction device for reaction to obtain a vegetable oil polyol; and (3) reacting the vegetable oil polyol prepared from the step (2) with a foam stabilizer, a cyclohexylamine, an isocyanate and a foaming agent cyclopentane for foaming so as to prepare a rigid polyurethane foam.Type: ApplicationFiled: April 12, 2021Publication date: July 29, 2021Inventors: Kai GUO, Zheng FANG, Chengkou LIU, Ning ZHU, Jingjing MENG, Junjie TAO, Xin HU, Xin LI, Chuanhong QIU, Pingkai OUYANG
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Publication number: 20210155917Abstract: The invention discloses a recombinant Corynebacterium glutamicum for producing lysine by biofilm continuous fermentation and a construction method thereof, wherein the recombinant Corynebacterium glutamicum is constructed by overexpressing a protease gene FtsH in a Corynebacterium glutamicum; and the construction method comprises the following steps of: (1) performing PCR on a genome of the Corynebacterium glutamicum, and amplifying the FtsH gene to obtain an amplified FtsH gene segment; (2) cloning the FtsH gene segment to an overexpression plasmid to obtain a recombinant plasmid; and (3) introducing the recombinant plasmid into the Corynebacterium glutamicum, and screening to obtain the recombinant Corynebacterium glutamicum.Type: ApplicationFiled: December 10, 2020Publication date: May 27, 2021Inventors: Hanjie Ying, Dong Liu, Yong Chen, Qingguo Liu, Pingkai Ouyang, Ming Lei, Huanqing Niu, Bin Yu, Di Zhang, Yuhan Yang, Shishi Wu
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Publication number: 20210147887Abstract: The invention discloses a method for producing lysine by utilizing adsorption and immobilized fermentation of a recombinant Corynebacterium glutamicum, wherein the recombinant Corynebacterium glutamicum is constructed by simultaneously overexpressing an adenosine triphosphate ATPase while knocking out an extracellular nuclease ExeR in a Corynebacterium glutamicum. The recombinant Corynebacterium glutamicum can effectively improve eDNA secretion of the Corynebacterium glutamicum and reduce eDNA degradation of the Corynebacterium glutamicum, so that the Corynebacterium glutamicum can be more easily adsorbed on a surface of a solid carrier for immobilized fermentation, such that a yield of continuous immobilized fermentation of the Corynebacterium glutamicum is increased by 49.67% than that of free fermentation of an original bacterium, and a fermentation cycle is shortened by 29.17%.Type: ApplicationFiled: December 10, 2020Publication date: May 20, 2021Inventors: Hanjie Ying, Dong Liu, Yong Chen, Pingkai Ouyang, Qingguo Liu, Huanqing Niu, Bin Yu, Xiwei Peng, Ming Lei, Xingyuan Cao
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Publication number: 20210087211Abstract: It discloses a polyether polyols for preparing flexible polyurethane foam, and a preparation method and application thereof. The method comprises the following steps: (1) carrying out a reaction on phosphorus oxychloride, epichlorohydrin, a first acidic catalyst and an inert solvent in a first microchannel reactor to obtain a chloroalkoxy phosphorus compound; (2) carrying out a reaction on the chloroalkoxy phosphorus compound, glycidol, a second acidic catalyst and an inert solvent in a second microchannel reactor to obtain a hydroxy compound; (3) carrying out a ring-opening reaction on the hydroxy compound, epoxy vegetable oil, a basic catalyst and an inert solvent in a third microchannel reactor to obtain a vegetable oil polyol; and (4) carrying out an addition polymerization reaction on the vegetable oil polyol, propylene oxide and an inert solvent in a fourth microchannel reactor to obtain the polyether polyols for preparing flexible polyurethane foam.Type: ApplicationFiled: December 1, 2020Publication date: March 25, 2021Inventors: Kai GUO, Zheng FANG, Wei HE, Ning ZHU, Xin HU, Jiangkai QIU, Chengkou LIU, Jingjing MENG, Jindian DUAN, Pingkai OUYANG
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Publication number: 20200377656Abstract: The method of the polyurethane polyol comprises (1) dissolving 2,3-epoxybutane and an acid catalyst in an inert solvent to obtain a solution A; dissolving triethylene glycol in an inert solvent to obtain a solution B; and dissolving epoxy vegetable oil in an inert solvent to obtain a solution C; (2) respectively and simultaneously pumping the solutions A and B into a first micromixer for mixing; (3) pumping the solution C and an effluent of the first microreactor into a second micromixer for mixing while carrying out step (2)?; and (4) dissolving the vegetable oil polyol in an inert solvent to obtain a solution D; dissolving epoxypropane and an alkaline catalyst in an inert solvent to obtain a solution E; and pumping the solution D and the solution E into a tank reactor for reaction, thereby obtaining the polyurethane polyol.Type: ApplicationFiled: August 21, 2020Publication date: December 3, 2020Inventors: Kai GUO, Zheng FANG, Man YANG, Junjie TAO, Ning ZHU, Wei HE, Kequan CHEN, Pingkai OUYANG
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Publication number: 20200048302Abstract: Disclosed is a multi-channel peptide synthesizer, including a gas-bath thermotank, a plurality of reactor tubes, a motor, a rotating rack, a liquid-feeding tube, a feeding device, a vacuum tube and a nitrogen tube. The gas-bath thermotank body provides a desired constant temperature for reaction. The reactor tube provides a place for peptide synthesis and resin washing. The motor and the rotating rack are used to fully mix the reaction and cleaning solutions. Various liquid reagents required are fed to the reactor tube through the liquid-adding tube. Various materials required are prepared in advance in the feeding device and directly fed to the reactor tube. The reaction or washing solution in the reactor tube is pumped to a waste liquid tank through the vacuum tube. Nitrogen is introduced into each reactor tube through the nitrogen tube. This device can be applied in batch-wise peptide synthesis using solid-phase methods.Type: ApplicationFiled: June 12, 2019Publication date: February 13, 2020Inventors: Xiaofang LUO, Yulu GONG, Zuodong QIN, Zongcheng WANG, Pingkai OUYANG
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Publication number: 20190119496Abstract: A method comprises enabling epoxy vegetable oil to react with a compound of a formula III in a second microstructured reactor to obtain the vegetable oil polyol. Compared with the existing technology, the present invention adopts a novel, environment-friendly ring-opening agent, the obtained polyol is novel in structure, high in hydroxyl value, even in distribution and low in viscosity, and can completely replace traditional petrochemical polyol to be applied to the preparation of polyurethane foam materials.Type: ApplicationFiled: December 14, 2018Publication date: April 25, 2019Inventors: Kai GUO, Zheng FANG, Chengkou LIU, Ning ZHU, Jingjing MENG, Junjie TAO, Xin HU, Xin LI, Chuanhong QIU, Pingkai OUYANG
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Publication number: 20190119493Abstract: A vegetable oil polyol for flexible polyurethane foam, a preparation method and application thereof. The method includes the following steps: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; and (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain the vegetable oil polyol for flexible polyurethane foam.Type: ApplicationFiled: December 14, 2018Publication date: April 25, 2019Inventors: Kai GUO, Zheng FANG, Junjie TAO, Wei He, Chengkou LIU, Jindian DUAN, Xin LI, Ning ZHU, Jiangkai QIU, Shiyu GUO, Pingkai OUYANG
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Publication number: 20190112475Abstract: A polyurethane polyol, and a preparation method and application thereof. The method comprises the following steps: (1) carrying out a reaction on phosphorus oxychloride, epichlorohydrin, a first acidic catalyst and an inert solvent in a first microchannel reactor to obtain a chloroalkoxy phosphorus compound; (2) carrying out a reaction on the chloroalkoxy phosphorus compound, glycidol, a second acidic catalyst and an inert solvent in a second microchannel reactor to obtain a hydroxy compound; (3) carrying out a ring-opening reaction on the hydroxy compound, epoxy vegetable oil, a basic catalyst and an inert solvent in a third microchannel reactor to obtain a vegetable oil polyol; and (4) carrying out an addition polymerization reaction on the vegetable oil polyol, propylene oxide and an inert solvent in a fourth microchannel reactor to obtain the polyurethane polyol.Type: ApplicationFiled: December 14, 2018Publication date: April 18, 2019Inventors: Kai GUO, Zheng FANG, Wei HE, Ning ZHU, Xin HU, Jiangkai QIU, Chengkou LIU, Jingjing MENG, Jindian DUAN, Pingkai OUYANG