Abstract: The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.

Abstract: The present invention is related to processes for preparing ruxolitinib, or a salt thereof, and related synthetic intermediates related thereto.

Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.

Abstract: The present disclosure discloses a rotary downhole cavitation generator, including an upper connector, a lower connector, and a casing. Said casing is internally provided with a transmission shaft, an alignment bearing, a drive assembly, a thrust bearing, a rotating disk, a rectification cylinder, an inner sleeve, and an outer sleeve. Said transmission shaft is provided with a deep hole, a diversion hole radially communicating with said deep hole, and a diversion channel radially communicating with said deep hole. Said alignment bearing and said drive assembly are sleeved on an upper end of said transmission shaft, and said rotating disk, said inner sleeve, and said thrust bearing are sleeved on a lower end of said transmission shaft. Said rectification cylinder and said outer sleeve are mounted on an inner wall of said casing, and said upper connector and said lower connector are respectively connected to both ends of said casing.

Abstract: The present invention is directed to 1, 2, 5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2, 3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1, 2, 5-oxadiazole derivatives.

Abstract: The present invention relates to an automatic cleaning device for suction port of electric submersible pump. The pipe string joint is connected between the oil pipe and the electric submersible pump. A plurality of oil drain passage inlets, steel balls, return springs, sealing plugs and oil drain passage outlets are evenly distributed in circumferential direction of a boss. The upper end of the connecting pipe is connected with the outlet of the oil drain passage, and the lower end is connected with the nozzle. The retaining ring secures the connecting pipe on the housing of the electric submersible pump. A high-pressure fluid ejected from the nozzle directly acts on the suction port of the electric submersible pump. The present invention can automatically clean the suction port of the electric submersible pump by relying on the pressure difference between the outlet and the suction port of the electric submersible pump.

Abstract: The present invention relates to a carbonate reservoir filtration-loss self-reducing acid fracturing method.

Abstract: The present invention relates to an automatic cleaning device for suction port of electric submersible pump. The pipe string joint is connected between the oil pipe and the electric submersible pump. A plurality of oil drain passage inlets, steel balls, return springs, sealing plugs and oil drain passage outlets are evenly distributed in circumferential direction of a boss. The upper end of the connecting pipe is connected with the outlet of the oil drain passage, and the lower end is connected with the nozzle. The retaining ring secures the connecting pipe on the housing of the electric submersible pump. A high-pressure fluid ejected from the nozzle directly acts on the suction port of the electric submersible pump. The present invention can automatically clean the suction port of the electric submersible pump by relying on the pressure difference between the outlet and the suction port of the electric submersible pump.

Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

Abstract: The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.

Abstract: The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.

Abstract: The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.

Abstract: The present invention relates to an amorphous solid form of (4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one, and processes for its preparation, which is an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and is useful in the treatment of various diseases such as cancer.

Abstract: The present invention relates to salt forms of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2?-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, including methods of preparation thereof, where the compound is useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

Abstract: This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of Janus kinases (JAK) including inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: The present invention relates to a carbonate reservoir filtration-loss self-reducing acid fracturing method.

Abstract: The present invention relates to an amorphous solid form of (4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one, and processes for its preparation, which is an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and is useful in the treatment of various diseases such as cancer.

Abstract: The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.

Abstract: The invention discloses a calculation method for dynamic fluid loss of acid-etched fracture considering wormhole propagation, which is applied to pad acid fracturing process, comprising the following steps: Step 1: dividing the construction time T of injecting acid fluid into artificial fracture into m time nodes at equal intervals, then the time step ?t=T/m and tn=n?t, where, n=0, 1, 2, 3, . . . , m, and to is the initial time; Step 2: calculating the fluid loss velocity vl(0) in the fracture at t0; Step 3: calculating the flowing pressure distribution P(n) in the fracture at tn; Step 4: calculating the width wa(n) of acid-etched fracture at tn; Step 5: calculating the wormhole propagation and the fluid loss velocity vl(n) at tn; Step 6: substituting the fluid loss velocity vl(n) into Step 3, and repeating Step 3 to Step 6 in turn until the end of acid fluid injection.