Abstract: The present invention relates to salts and solid forms of the FGFR inhibitor (7R,8aS)-2-(5-(5-(2,3-Dimethylphenyl)-6-methoxy-1H-pyrazolo[4,3-b]pyridin-3-yl)pyridin-2-yl)octahydropyrrolo[1,2-a]pyrazin-7-ol, including methods of preparation thereof, wherein the compounds, salts, and solid forms are useful in the treatment of FGFR-mediated diseases such as cancer.

Abstract: The present invention discloses a method for predicting fracture height during fracturing stimulation in multi-layer formation, comprising specific steps of: (1) acquiring basic parameters; (2) calculating a displacement discontinuity quantity of an artificial fracture; (3) calculating induced stress generated by the fracture; (4) calculating stress intensity factors at a fracture tip without considering a fracture tip plasticity; (5) calculating sizes of a plastic zone; (6) calculating stress intensity factors at the fracture tip considering the plastic zone; and (7) judging a relationship between the stress intensity factors and a fracture toughness. The present invention is suitable for multiple stratums, and the influences of parameters of tip plasticity, induced stress, crustal stress, and rock mechanics are considered so that a calculation result is more accurate and calculation efficiency is higher.

Abstract: The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.

Abstract: The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.

Abstract: The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

Abstract: The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.

Abstract: The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.

Abstract: The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.

Abstract: The present invention relates to crystalline forms of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2?-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, including methods of preparation thereof, and related synthetic intermediates, where the compound is useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: The present invention relates to processes of preparing PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2?-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or salts thereof, related synthetic intermediates, and salts of the intermediates, where the PD-1/PD-L1 inhibitor is useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: The present disclosure discloses a rotary downhole cavitation generator, including an upper connector, a lower connector, and a casing. Said casing is internally provided with a transmission shaft, an alignment bearing, a drive assembly, a thrust bearing, a rotating disk, a rectification cylinder, an inner sleeve, and an outer sleeve. Said transmission shaft is provided with a deep hole, a diversion hole radially communicating with said deep hole, and a diversion channel radially communicating with said deep hole. Said alignment bearing and said drive assembly are sleeved on an upper end of said transmission shaft, and said rotating disk, said inner sleeve, and said thrust bearing are sleeved on a lower end of said transmission shaft. Said rectification cylinder and said outer sleeve are mounted on an inner wall of said casing, and said upper connector and said lower connector are respectively connected to both ends of said casing.

Abstract: The present invention is related to processes for preparing ruxolitinib, or a salt thereof, and related synthetic intermediates related thereto.

Abstract: The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.

Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.

Abstract: The present disclosure discloses a rotary downhole cavitation generator, including an upper connector, a lower connector, and a casing. Said casing is internally provided with a transmission shaft, an alignment bearing, a drive assembly, a thrust bearing, a rotating disk, a rectification cylinder, an inner sleeve, and an outer sleeve. Said transmission shaft is provided with a deep hole, a diversion hole radially communicating with said deep hole, and a diversion channel radially communicating with said deep hole. Said alignment bearing and said drive assembly are sleeved on an upper end of said transmission shaft, and said rotating disk, said inner sleeve, and said thrust bearing are sleeved on a lower end of said transmission shaft. Said rectification cylinder and said outer sleeve are mounted on an inner wall of said casing, and said upper connector and said lower connector are respectively connected to both ends of said casing.

Abstract: The present invention is directed to 1, 2, 5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2, 3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1, 2, 5-oxadiazole derivatives.

Abstract: The present invention relates to an automatic cleaning device for suction port of electric submersible pump. The pipe string joint is connected between the oil pipe and the electric submersible pump. A plurality of oil drain passage inlets, steel balls, return springs, sealing plugs and oil drain passage outlets are evenly distributed in circumferential direction of a boss. The upper end of the connecting pipe is connected with the outlet of the oil drain passage, and the lower end is connected with the nozzle. The retaining ring secures the connecting pipe on the housing of the electric submersible pump. A high-pressure fluid ejected from the nozzle directly acts on the suction port of the electric submersible pump. The present invention can automatically clean the suction port of the electric submersible pump by relying on the pressure difference between the outlet and the suction port of the electric submersible pump.

Abstract: The present invention relates to a carbonate reservoir filtration-loss self-reducing acid fracturing method.

Abstract: The present invention relates to an automatic cleaning device for suction port of electric submersible pump. The pipe string joint is connected between the oil pipe and the electric submersible pump. A plurality of oil drain passage inlets, steel balls, return springs, sealing plugs and oil drain passage outlets are evenly distributed in circumferential direction of a boss. The upper end of the connecting pipe is connected with the outlet of the oil drain passage, and the lower end is connected with the nozzle. The retaining ring secures the connecting pipe on the housing of the electric submersible pump. A high-pressure fluid ejected from the nozzle directly acts on the suction port of the electric submersible pump. The present invention can automatically clean the suction port of the electric submersible pump by relying on the pressure difference between the outlet and the suction port of the electric submersible pump.

Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.