Patents by Inventor Pingyun Chen

Pingyun Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALT OF BENZOTHIAZOLE COMPOUND, AND CRYSTAL FORM AND USE THEREOF
    Publication number: 20230365518
    Abstract: Provided in the present invention are a salt of a benzothiazole compound as represented by formula I and a crystal form and the use thereof. The salt is selected from pamoate and palmitate. Further provided is the use of the salt of the compound of formula I and the crystal form thereof in the preparation of a drug for treating Parkinson's disease and restless leg syndrome.
    Type: Application
    Filed: November 9, 2021
    Publication date: November 16, 2023
    Inventors: Long LI, Shidong YI, Tianming WANG, Pingyun CHEN, Chengxi YANG, Jingyi WANG
  • SALT AND CRYSTAL FORM OF PYRIMIDINE COMPOUND, AND PREPARATION METHODS THEREFOR
    Publication number: 20230295174
    Abstract: Provided are a salt and a crystal form of a pyrimidine compound, and preparation methods therefor. Specifically, provided are a salt and a crystal form of a compound I, including a crystal form of the salt, and preparation methods therefor.
    Type: Application
    Filed: July 23, 2021
    Publication date: September 21, 2023
    Inventors: Zheng Gong, Hongming Li, Shidong Yi, Long Li, Tianming Wang, Pingyun Chen, Chengxi Yang, Tao Wang, Yaoyao Song, Jiangfeng Zhou, Yufeng Liang, Zhonghui Chen, Qiang Tian, Hongmei Song, Tongtong Xue, Jingyi Wang
  • Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone
    Patent number: 10035787
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: July 31, 2018
    Assignee: ELI LILLY AND COMPANY
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • Chemical compounds
    Patent number: 9814699
    Abstract: Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 14, 2017
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Pingyun Chen, Ricky Couch, Maosheng Duan, Beth Adams Norton
  • NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE
    Publication number: 20170283394
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Application
    Filed: June 15, 2017
    Publication date: October 5, 2017
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl)-(2-chlorophenyl)-methanone
    Patent number: 9708291
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 18, 2017
    Assignee: Vanda Pharmaceuticals Inc.
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 9687497
    Abstract: Disclosed herein is the crystalline form of the potassium salt of 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid. The crystalline form maybe formulated for treating subjects with bacterial infection. Accordingly, some embodiments relate to compositions and methods of administering the potassium salt of 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: June 27, 2017
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Joanna A. Bis, Pingyun Chen, Senthil Kumar Kusalakumari Sukumar
  • SALTS AND POLYMORPHS OF CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20170173055
    Abstract: Disclosed herein is the crystalline form of the potassium salt of 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid. The crystalline form maybe formulated for treating subjects with bacterial infection. Accordingly, some embodiments relate to compositions and methods of administering the potassium salt of 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid.
    Type: Application
    Filed: April 29, 2015
    Publication date: June 22, 2017
    Inventors: Joanna A. Bis, Pingyun Chen, Senthil Kumar Kusalakumari Sukumar
  • CHEMICAL COMPOUNDS
    Publication number: 20160158201
    Abstract: Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 9, 2016
    Inventors: Pingyun Chen, Ricky Couch, Maosheng Duan, Beth Adams Norton
  • NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE
    Publication number: 20160060250
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Application
    Filed: November 10, 2015
    Publication date: March 3, 2016
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • CHEMICAL COMPOUNDS
    Publication number: 20150374668
    Abstract: Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
    Type: Application
    Filed: September 9, 2015
    Publication date: December 31, 2015
    Inventors: Pingyun Chen, Ricky Couch, Maosheng Duan, Beth Adams Norton
  • Chemical compounds
    Patent number: 9150587
    Abstract: Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: October 6, 2015
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Pingyun Chen, Ricky Couch, Maosheng Duan, Beth Adams Norton
  • ACH-0142684 sodium salt polymorph, composition including the same, and method of manufacture thereof
    Patent number: 9085607
    Abstract: The disclosure provides a crystalline sodium salt of ACH-0142684 comprising a Form A polymorph, a Form B polymorph, a Form C polymorph, a Form D polymorph, a Form E polymorph, a Form F polymorph, a Form G polymorph, a Form H polymorph, a Form I polymorph, or a combination thereof, wherein the Form A, B, C, D, E, F, G, H, and I polymorph exhibits an X-ray powder diffraction pattern having peak locations in accordance with FIGS. 8; 12; 15; 21; 22; 27; 30, and 31, respectively.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: July 21, 2015
    Assignee: ACHILLION PHARMACEUTICALS, INC.
    Inventors: Avinash Phadke, Akihiro Hashimoto, Pingyun Chen, Senthil Kumar Kusalakumari Sukumar
  • Chemical compounds
    Publication number: 20140371455
    Abstract: Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 18, 2014
    Inventors: Pingyun Chen, Ricky Couch, Maosheng Duan, Beth Adams Norton
  • Heterocyclic inhibitors of histamine receptors for the treatment of disease
    Patent number: 8859550
    Abstract: The present invention relates to salts, hydrates, and polymorphs of bicyclic heteroaryl compounds, and pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of diseases including allergic rhinitis.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: October 14, 2014
    Assignee: Kalypsys, Inc.
    Inventors: Pingyun Chen, Stephen A. R. Carino, Ricky Wayne Couch, Daniel S. Kinder, Beth A. Norton
  • Chemical compounds
    Patent number: 8853416
    Abstract: Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: October 7, 2014
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Pingyun Chen, Ricky Couch, Maosheng Duan, Beth Adams Norton
  • ACH-0142684 SODIUM SALT POLYMORPH, COMPOSITION INCLUDING THE SAME, AND METHOD OF MANUFACTURE THEREOF
    Publication number: 20140274914
    Abstract: The disclosure provides a crystalline sodium salt of ACH-0142684 comprising a Form A polymorph, a Form B polymorph, a Form C polymorph, a Form D polymorph, a Form E polymorph, a Form F polymorph, a Form G polymorph, a Form H polymorph, a Form I polymorph, or a combination thereof, wherein the Form A, B, C, D, E, F, G, H, and I polymorph exhibits an X-ray powder diffraction pattern having peak locations in accordance with FIGS. 8; 12; 15; 21; 22; 27; 30, and 31, respectively.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Applicant: Achillion Pharmaceuticals Inc.
    Inventors: Avinash Phadke, Akihiro Hashimoto, Pingyun Chen, Senthil Kumar Kusalakumari Sukumar
  • NOVEL INTERMEDIATE AND PROCESS USEFUL IN THE PREPARATION OF -(2-CHLOROPHENYL)-METHANONE
    Publication number: 20140206877
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 24, 2014
    Applicant: Eli Lilly and Company
    Inventors: Michael Edward Kobierski, Michael E. Kopach, Pingyun Chen
  • Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone
    Patent number: 8772496
    Abstract: The present invention relates to novel compounds, (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone benzoate, and (2-chlorophenyl)-[2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-yl]methanone toluate, which are useful intermediates for the preparation of the compound of Formula I: (I) The present invention further relates to novel processes for preparing a crystalline compound, which is {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, Form IV.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: July 8, 2014
    Assignee: Eli Lilly and Company
    Inventor: Pingyun Chen
  • Hair dryer toy
    Patent number: D1020920
    Type: Grant
    Filed: December 29, 2023
    Date of Patent: April 2, 2024
    Inventor: Pingyun Chen