Abstract: A quick release assembly for supporting a bicycle wheel hub on a bicycle frame component. The assembly includes an elongated rod having an abutment nut threadedly disposed on one end thereof and a cam clamping assembly disposed on the other end. The clamping assembly includes a cup-shaped clamping head for rotatably supporting a cam member having an eccentric cam disposed within the cup-shaped clamping head. The eccentric cam is rotatably disposed in openings in a cylindrical reaction member. The cylindrical reaction member has a bore extending thereinto from one face to an annular flange adjacent the second face and the end of the rod has an enlarged head disposed in the bore of the reaction member and engaging the annular flange. The reaction member and the rod are separate members and the end of the rod has an arcuate recess concentric with the eccentric cam for engaging the eccentric cam to prevent rotation of the rod.