Patents by Inventor Pin-Yi Wang

Pin-Yi Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CANCER-TARGETED, VIRUS-ENCODED, REGULATABLE T (CATVERT) OR NK CELL (CATVERN) LINKERS
    Publication number: 20260137779
    Abstract: Recombinant polynucleotides and vectors containing an engineered (artificial) exon-intron-exon gene structure in a transgene are provided, which undergoes splicing when it is expressed in a target cell.
    Type: Application
    Filed: January 16, 2026
    Publication date: May 21, 2026
    Inventors: Timothy P. Cripe, Chun-yu Chen, Brian Hutzen, Mark Currier, Pin-yi Wang, Dawn Chandler
  • MACROPHAGE POLARIZING ONCOLYTIC HERPES SIMPLEX VIRUS FOR CANCER THERAPY
    Publication number: 20260097088
    Abstract: This disclosure relates to a modified oncolytic herpes simplex virus (oHSV) comprising an expression cassette encoding a histidine-rich glycoprotein (HRG), and uses thereof. One promising avenue for the treatment of cancer is oncolytic virotherapy, e.g., oncolytic Herpes Simplex Virus (oHSV) which utilizes genetically modified viruses to selectively target and lyse cancer cells while sparing the normal cells. Oncolytic virotherapy is a safe and effective immunotherapeutic platform for different types of cancers.
    Type: Application
    Filed: August 17, 2023
    Publication date: April 9, 2026
    Inventors: Chun-Yu Chen, Pin-Yi Wang, Timothy P. Cripe
  • Syncytial oncolytic herpes simplex mutants as potent cancer therapeutics
    Patent number: 12480097
    Abstract: The disclosure provides a non-natural herpes simplex virus (“HSV”), compositions comprising, or alternatively consisting essentially of, or yet further consisting of the HSV, and methods of producing the HSV, or infecting a cell with the HSV. Also provided herein are methods of treating cancer or inhibiting the growth or metastasis of cancer cell in a subject in need thereof.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: November 25, 2025
    Assignee: Research Institute at Nationwide Children's Hospital
    Inventors: Timothy P. Cripe, Kevin A. Cassady, Pin-Yi Wang, Julia K. Halley
  • CANCER-TARGETED, VIRUS-ENCODED, REGULATABLE T (CATVERT) OR NK CELL (CATVERN) LINKERS
    Publication number: 20220257760
    Abstract: Recombinant polynucleotides and vectors containing an engineered (artificial) exon-intron-exon gene structure in a transgene are provided, which undergoes splicing when it is expressed in a target cell.
    Type: Application
    Filed: February 19, 2020
    Publication date: August 18, 2022
    Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: Timothy P. Cripe, Chun-yu Chen, Brian Hutzen, Mark Currier, Pin-yi Wang, Dawn Chandler
  • SYNCYTIAL ONCOLYTIC HERPES SIMPLEX MUTANTS AS POTENT CANCER THERAPEUTICS
    Publication number: 20220154149
    Abstract: The disclosure provides a non-natural herpes simplex virus (“HSV”), compositions comprising, or alternatively consisting essentially of, or yet further consisting of the HSV, and methods of producing the HSV, or infecting a cell with the HSV. Also provided herein are methods of treating cancer or inhibiting the growth or metastasis of cancer cell in a subject in need thereof.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: Timothy P. Cripe, Kevin A. Cassady, Pin-Yi Wang, Julia K. Halley