Abstract: A system for use in transseptally delivering a cardiac therapeutic device (“CTD”) to a target site in the heart, includes a CTD having an elongate flexible advancer on its distal end, and a flexible member proportioned for introduction into a vasculature and having a length to extend from the right subclavian vein, through the heart via a transseptal puncture, and to a femoral artery such that a first end of the flexible member is external to the patient at the right subclavian vein or other venous access site and a second end of the flexible member is external to the patient at the femoral artery. The flexible member has a grasper releasably engageable with the advancer.