Patents by Inventor Piotr Graczyk

Piotr Graczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • JNK inhibitors
    Patent number: 7612086
    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: November 3, 2009
    Assignee: Eisai R & D Management Co. Ltd.
    Inventors: Piotr Graczyk, Vanessa Palmer, Afzal Khan
  • JNK INHIBITORS
    Publication number: 20090215771
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: June 20, 2008
    Publication date: August 27, 2009
    Inventors: Piotr GRACZYK, Afzal KHAN, Gurpreet BHATIA, Yoichi IIMURA
  • 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders
    Patent number: 7534800
    Abstract: The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: May 19, 2009
    Assignee: Eisai R & D Development Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer
  • JNK inhibitors
    Patent number: 7432375
    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: October 7, 2008
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Piotr Graczyk, Afzal Khan, Gurpreet Bhatia, Yoichi Iimura
  • Jun kinase inhibitors
    Patent number: 7314940
    Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: January 1, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer, Darren Peter Medland, Hitoshi Oinuma, Gurpreet Bhatia
  • Azaindoles as inhibitors of c-Jun N-terminal kinases
    Patent number: 7291630
    Abstract: The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: November 6, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Gurpreet Bhatia, Darren Peter Medland
  • Jnk inhibitors
    Publication number: 20070142366
    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: May 14, 2004
    Publication date: June 21, 2007
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Vanessa Palmer, Afzal Khan
  • Jnk inhibitors
    Publication number: 20060270646
    Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: March 5, 2004
    Publication date: November 30, 2006
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Afzat Khan, Gurpreet Bhatia, Yoichi Iimura
  • Synthesis
    Publication number: 20060235042
    Abstract: The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.
    Type: Application
    Filed: March 5, 2004
    Publication date: October 19, 2006
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Afzal Khan, Gurpreet Bhatia
  • Azaindoles as inhibitors of c-jun n-terminal kinases
    Publication number: 20060111390
    Abstract: The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Application
    Filed: March 17, 2003
    Publication date: May 25, 2006
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Gurpreet Bhatia, Darren Medland
  • 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
    Publication number: 20050272761
    Abstract: The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
    Type: Application
    Filed: March 17, 2003
    Publication date: December 8, 2005
    Applicant: Eisai Co., Ltd.
    Inventors: Piotr Graczyk, Hirotoshi Numata, Afzal Khan, Vanessa Palmer
  • Jun kinase inhibitors
    Publication number: 20040235864
    Abstract: The present invention provides novel compounds of formula I 1
    Type: Application
    Filed: April 23, 2004
    Publication date: November 25, 2004
    Inventors: Piotr Graczyk, Hiroshi Numata, Afzal Khan, Vanessa Palmer, Darren Peter Medland, Hitoshi Oinuma, Gurpreet Bhatia