Patents by Inventor Piotr H. Karpinski

Piotr H. Karpinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8486930
    Abstract: This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: July 16, 2013
    Assignee: Novartis AG
    Inventors: Marilyn De La Cruz, Piotr H. Karpinski, Yugang Liu
  • Patent number: 8389537
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: March 5, 2013
    Assignee: Novartis AG
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Publication number: 20130023548
    Abstract: Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Application
    Filed: August 3, 2012
    Publication date: January 24, 2013
    Inventors: Paul W. MANLEY, Wen-Chung SHIEH, Paul Allen SUTTON, Piotr H. KARPINSKI, Raeann WU, Stéphanie MONNIER, Jörg BROZIO
  • Publication number: 20120308651
    Abstract: Salts of benzimidazolyl pyridyl ethers are provided, particularly salts of {1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yloxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethyl-phenyl)amine. Compositions and formulations including such salts and surfactants as well as methods of preparing such compositions and formulations are provided.
    Type: Application
    Filed: June 4, 2012
    Publication date: December 6, 2012
    Inventors: Rampurna Gullapalli, Ahmad Hashash, Piotr H. Karpinski, Kangwen L. Lin, Eric M. Loeser, Augustus Okhamafe, Paul Allen Sutton, Eduardo Sy
  • Publication number: 20120270891
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Application
    Filed: March 13, 2012
    Publication date: October 25, 2012
    Inventors: Paul W. Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H. Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Patent number: 8202998
    Abstract: Salts of benzimidazolyl pyridyl ethers are provided, particularly salts of {1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yloxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethyl-phenyl)amine. Compositions and formulations including such salts and surfactants as well as methods of preparing such compositions and formulations are provided.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: June 19, 2012
    Assignee: Novartis AG
    Inventors: Rampurna Gullapalli, Ahmad Hashash, Piotr H. Karpinski, Kangwen L. Lin, Eric M. Loeser, Augustus Okhamafe, Paul Allen Sutton, Eduardo Sy
  • Publication number: 20120115840
    Abstract: This invention relates to a hemifumarate salt of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of the hemifumarate salt form of Compound I, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: December 16, 2009
    Publication date: May 10, 2012
    Inventors: Lech Ciszewski, Marilyn De La Cruz, Piotr H. Karpinski, Michael Mutz, Christian Riegert, Caspar Vogel, Ricardo Schneeberger
  • Patent number: 8163904
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: April 24, 2012
    Assignees: Novartis AG, Novartis Pharma GmbH
    Inventors: Paul W Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H Karpinski, Raeann Wu, Stéphanie Monnier, Jörg Brozio
  • Publication number: 20110257150
    Abstract: This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: December 17, 2009
    Publication date: October 20, 2011
    Inventors: Marilyn De La Cruz, Piotr H. Karpinski, Yugang Liu
  • Patent number: 7977330
    Abstract: The invention relates to salts of 1-(2-Fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea and crystalline forms thereof, their production and usage, and pharmaceutical preparations containing such salts and crystalline forms.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: July 12, 2011
    Assignee: Novartis AG
    Inventors: Lilli Feng, Xinglong Jiang, Piotr H. Karpinski
  • Publication number: 20100168060
    Abstract: Salts of benzimidazolyl pyridyl ethers are provided, particularly salts of {1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yloxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethyl-phenyl)amine. Compositions and formulations including such salts and surfactants as well as methods of preparing such compositions and formulations are provided.
    Type: Application
    Filed: August 30, 2007
    Publication date: July 1, 2010
    Applicant: Novartis AG
    Inventors: Rampurna Gullapalli, Ahmad Hashash, Piotr H. Karpinski, Kangwen L. Lin, Eric M. Loeser, Augustus O. Okhamafe, Paul Allen Sutton, Eduardo Sy
  • Publication number: 20090163478
    Abstract: The invention relates to salts of 1-(2-Fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea and crystalline forms thereof, their production and usage, and pharmaceutical preparations containing such salts and crystalline forms.
    Type: Application
    Filed: May 21, 2007
    Publication date: June 25, 2009
    Inventors: Lili Feng, Xinglong Jiang, Piotr H. Karpinski
  • Publication number: 20080269269
    Abstract: Polymorphic forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide free base and salts thereof are prepared by various processes.
    Type: Application
    Filed: July 18, 2006
    Publication date: October 30, 2008
    Inventors: Paul W. Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H. Karpinski, Raeann Wu, Stephanie Monnier, Jorg Brozio
  • Publication number: 20080200487
    Abstract: Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide are prepared by various processes.
    Type: Application
    Filed: July 18, 2006
    Publication date: August 21, 2008
    Inventors: Paul W. Manley, Wen-Chung Shieh, Paul Allen Sutton, Piotr H. Karpinski, Raeann Wu, Stephanie Monnier, Jorg Brozio
  • Patent number: 5560932
    Abstract: This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of a suitable surface-modifying, surface-active agent to form a fine particle dispersion of the said pharmaceutical agent. This can be preferably followed by steps of diafiltration clean-up of the dispersion and then concentration of it to a desired level. This process of dispersion preparation leads to microcrystalline particles of Z-average diameters smaller than 400 nm as measured by photon correlation spectroscopy. Various modification of precipitation schemes are described, many of which are suitable for large-scale manufacture of these agent dispersions.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: October 1, 1996
    Assignee: Nano Systems L.L.C.
    Inventors: Pranab Bagchi, Piotr H. Karpinski, Gregory L. McIntire
  • Patent number: 5401492
    Abstract: This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns.In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate.In another preferred embodiment, the composition of the present invention further comprises a surfactant.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: March 28, 1995
    Assignee: Sterling Winthrop, Inc.
    Inventors: Kenneth E. Kellar, Piotr H. Karpinski, Elaine Liversidge, Wolfgang H. H. Gunther, Gregory L. McIntire, Barbara Van Orman