Patents by Inventor Piotr J. Czernik

Piotr J. Czernik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses of human UDP-glucuronosyltransferase 2B7 to detect and treat cancer
    Patent number: 7097992
    Abstract: Human UDP-glucuronosyltransferase 2B7 (UGT2B7) protein expression is limited to ovarian surface epithelium cells and that this protein is not present in tumors arising from this cell layer. UDP-glucuronosyltransferase 2B7 protein accumulates in cells when the cells enter stationary phase and growth inhibition. UGT2B7 protein is not expressed in exponentially growing ovarian tumor cells. Overexpression of UGT2B7 protein in human ovarian tumor cells results in cell growth arrest, significant reduction of lipid content and changes in cell morphology. Thus, active UGT2B7 protein expression in tumor cells can be used to decrease cell proliferation and to treat various cancers, whereas UGT2B7 mRNA expression, protein expression and/or enzymatic activity can be used as a tumor specific marker in diagnostic procedures.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: August 29, 2006
    Inventors: Piotr J. Czernik, Anna Radominska-Pandya
  • Uses of human UDP-glucuronosyltransferase 2B7 to detect and treat cancer
    Publication number: 20020198167
    Abstract: Human UDP-glucuronosyltransferase 2B7 (UGT2B7) protein expression is limited to ovarian surface epithelium cells and that this protein is not present in tumors arising from this cell layer. UDP-glucuronosyltransferase 2B7 protein accumulates in cells when the cells enter stationary phase and growth inhibition. UGT2B7 protein is not expressed in exponentially growing ovarian tumor cells. Overexpression of UGT2B7 protein in human ovarian tumor cells results in cell growth arrest, significant reduction of lipid content and changes in cell morphology. Thus, active UGT2B7 protein expression in tumor cells can be used to decrease cell proliferation and to treat various cancers, whereas UGT2B7 mRNA expression, protein expression and/or enzymatic activity can be used as a tumor specific marker in diagnostic procedures.
    Type: Application
    Filed: April 25, 2002
    Publication date: December 26, 2002
    Inventors: Piotr J. Czernik, Anna Radominska-Pandya