Patents by Inventor Piotr Marszalek

Piotr Marszalek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF IMPROVING SPECIFICITY IN GENOMIC ENGINEERING USING RNA-GUIDED ENDONUCLEASES
    Publication number: 20230304000
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and reduced off-target binding.
    Type: Application
    Filed: August 26, 2022
    Publication date: September 28, 2023
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • COMPOSITIONS AND METHODS OF IMPROVING SPECIFICITY IN GENOMIC ENGINEERING USING RNA-GUIDED ENDONUCLEASES
    Publication number: 20230047669
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs.
    Type: Application
    Filed: August 2, 2022
    Publication date: February 16, 2023
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • Compositions and methods of improving specificity in genomic engineering using RNA-guided endonucleases
    Patent number: 11427817
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • COMPOSITIONS AND METHODS OF IMPROVING SPECIFICITY IN GENOMIC ENGINEERING USING RNA-GUIDED ENDONUCLEASES
    Publication number: 20190136229
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and reduced off-target binding.
    Type: Application
    Filed: August 25, 2016
    Publication date: May 9, 2019
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • Methods, devices, systems and computer program products for stochastic, competitive, force-based analyte detection
    Patent number: 7598092
    Abstract: A cantilever array can be positioned adjacent a surface in the presence of a sample. The cantilever array includes a plurality of cantilevers having one member of a specific binding pair thereon. The surface includes the other member of a specific binding pair. Binding between the members of the binding pair on the cantilevers and the surface can be detected. The presence, absence and/or concentration of a member of the specific binding pair in the sample can be detected based on the detected binding between the specific binding pair member on the cantilevers and the specific binding pair member on the surface.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: October 6, 2009
    Inventors: Eric Toone, Piotr Marszalek, Robert L. Clark, Phil Snyder
  • METHODS, DEVICES, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR STOCHASTIC, COMPETITIVE, FORCE-BASED ANALYTE DETECTION
    Publication number: 20080090259
    Abstract: A cantilever array can be positioned adjacent a surface in the presence of a sample. The cantilever array includes a plurality of cantilevers having one member of a specific binding pair thereon. The surface includes the other member of a specific binding pair. Binding between the members of the binding pair on the cantilevers and the surface can be detected. The presence, absence and/or concentration of a member of the specific binding pair in the sample can be detected based on the detected binding between the specific binding pair member on the cantilevers and the specific binding pair member on the surface.
    Type: Application
    Filed: June 7, 2007
    Publication date: April 17, 2008
    Inventors: Eric Toone, Piotr Marszalek, Robert Clark, Phil Snyder