Patents by Inventor Piotr Pawel Graczyk

Piotr Pawel Graczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase
    Patent number: 8178552
    Abstract: The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: May 15, 2012
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Piotr Pawel Graczyk, Paschalis Dimopoulos, Afzal Khan, Gurpreet Singh Bhatia, Christopher Neil Farthing
  • DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE
    Publication number: 20110195951
    Abstract: The invention relates to diazaindole derivatives represented by the general formula (I): where A, E, G, R1, R2, R3 and R4 are defined herein, or pharmaceutically acceptable salts thereof, their use in the inhibition of c-Jun N-terminal kinase (JNK) activity, their use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases, autoimmune diseases and/or organ failure. The invention also provides processes for the manufacture of said diazaindole derivatives and compositions containing them.
    Type: Application
    Filed: July 28, 2009
    Publication date: August 11, 2011
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Piotr Pawel Graczyk, Gurpreet Singh Bhatia
  • 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS
    Publication number: 20110166173
    Abstract: The present invention provides novel compounds of forumula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
    Type: Application
    Filed: March 3, 2005
    Publication date: July 7, 2011
    Applicant: Eisai Co., Ltd.
    Inventors: Darren Peter Medland, Piotr Pawel Graczyk, Gurpreet Singh Bhatia
  • Use of 7-azaindoles in the inhibition of c-Jun N-terminal kinase
    Patent number: 7951802
    Abstract: The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: May 31, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Piotr Pawel Graczyk, Paschalis Dimopoulos, Christopher Neil Farthing, Gurpreet Singh Bhatia, Afzal Khan
  • USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE
    Publication number: 20100069358
    Abstract: The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
    Type: Application
    Filed: August 5, 2009
    Publication date: March 18, 2010
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Piotr Pawel GRACZYK, Paschalis DIMOPOULOS, Christopher Neil FARTHING, Gurpreet Singh BHATIA, Afzal KHAN
  • 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE
    Publication number: 20100069354
    Abstract: The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
    Type: Application
    Filed: August 5, 2009
    Publication date: March 18, 2010
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Piotr Pawel GRACZYK, Paschalis DIMOPOULOS, Afzal KHAN, Gurpreet Singh BHATIA, Christopher Neil FARTHING
  • Synthesis of 5 substituted 7-azaindoles and 7-azaindolines
    Patent number: 7652137
    Abstract: The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: January 26, 2010
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Piotr Pawel Graczyk, Afzal Khan, Gurpreet Singh Bhatia