Patents by Inventor Pirmin Hidber

Pirmin Hidber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180055845
    Abstract: The present invention relates to pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer as well as processes for their preparation and their use as medicament.
    Type: Application
    Filed: August 9, 2017
    Publication date: March 1, 2018
    Applicant: Genentech, Inc.
    Inventors: REINHARD REENTS, PIRMIN HIDBER, ANDRE HELL, PETER STEIDLE, MARTIN WUNDERLICH, MARIE PEPELNJAK, FRANCIS GOSSELIN, EDWARD YOST
  • Patent number: 8895729
    Abstract: Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: November 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Srinivasan Babu, Zhigang Cheng, Francis Gosselin, Pirmin Hidber, Ursula Hoffmann, Theresa Humphries, Reinhard Reents, Qingping Tian, Herbert Yajima
  • Patent number: 8765989
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: July 1, 2014
    Assignee: Hoffmann - La Roche Inc.
    Inventors: Declan Costello, Gerard John Hamett, Pirmin Hidber, Ursula Hoffmann, Thomas McCarthy, Reinhard Reents, Dennis A. Smith, Timothy Smyth
  • Publication number: 20140100366
    Abstract: Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 10, 2014
    Applicant: Genentech, Inc.
    Inventors: Srinivasan Babu, Zhigang Cheng, Francis Gosselin, Pirmin Hidber, Ursula Hoffmann, Theresa Humphries, Reinhard Reents, Qingping Tian, Herbert Yajima
  • Publication number: 20130338391
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.
    Type: Application
    Filed: August 22, 2013
    Publication date: December 19, 2013
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Declan Costello, Gerard John Harnett, Pirmin Hidber, Ursula Hoffmann, Thomas McCarthy, Reinhard Reents, Dennis A. Smith, Timothy Smyth
  • Patent number: 7867452
    Abstract: A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: January 11, 2011
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Publication number: 20110004011
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 6, 2011
    Inventors: Declan Costello, Gerard John Harnett, Pirmin Hidber, Ursula Hoffmann, Thomas McCarthy, Reinhard Reents, Dennis A. Smith, Timothy Smyth
  • Publication number: 20070297950
    Abstract: An equilibration device for equilibrating a comparably economic equilibration of a fluid. A first sealing layer is adjacent to the surface side between the plate and the cover. A second sealing layer is arrangeable adjacent to the cover between the plate and the cover and a tube with an open end, which is inside the well such that the open end of the tube projects above the opening of the well. The use of two sealing layers in the equilibration device allows combining the advantages of a material of the first sealing layer, e.g. high flexibility to seal uneven areas and to compensate the step formed by the tube projecting above the opening of the well, as well as the advantages of the second sealing layer, e.g. inexpensiveness, can come to combined effect when the two sealing layers are arranged appropriately.
    Type: Application
    Filed: June 14, 2007
    Publication date: December 27, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Publication number: 20070264163
    Abstract: A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 15, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Patent number: 7148231
    Abstract: The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: December 12, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andre Gerard Bubendorf, Michael Hennig, Pirmin Hidber, Goesta Rimmler, Franziska Rohrer
  • Publication number: 20040162300
    Abstract: The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph.
    Type: Application
    Filed: February 3, 2004
    Publication date: August 19, 2004
    Inventors: Andre Gerard Bubendorf, Michael Hennig, Pirmin Hidber, Goesta Rimmler, Franziska Rohrer
  • Patent number: 6299906
    Abstract: The present invention relates to a process for manufacturing a pulverous preparation of a submicron-sized biologically active compound comprising the steps of dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; and rapidly expanding the compressed solution thereby precipitating the dissolved compound. An alternative process comprises dissolving the biologically active compound in compressed dimethylether, which may optionally contain a surface modifier; and spraying the compressed solution into an antisolvent phase, optionally containing a surface modifier, under vacuum, atmospheric pressure or elevated pressure. An optional third step involves converting the antisolvent phase into a pulverous preparation using conventional powder processing.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: October 9, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Bausch, Pirmin Hidber
  • Patent number: 6060121
    Abstract: A method of transferring a chemical activating agent from an applicator to a substrate surface involves providing an applicator having a raised application surface, applying a chemical activating agent to the application surface, contacting the substrate surface with the application surface, and removing the applicator. The chemical activating agent is transferred in a form in which it is capable of effecting a chemical reaction, such as catalysis, at the surface. Thus, following transfer of the chemical activating agent to the surface in a pattern, a metal can be plated at the substrate surface in the pattern. The applicator can be an elastomeric stamp having a raised portion defining a stamping surface.
    Type: Grant
    Filed: March 15, 1996
    Date of Patent: May 9, 2000
    Assignee: President and Fellows of Harvard College
    Inventors: Pirmin Hidber, Wolfgang Helbig, Enoch Kim, George M. Whitesides