Patents by Inventor Pirouz Daftarian

Pirouz Daftarian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticle conjugates and uses thereof
    Patent number: 11364305
    Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a cell.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: June 21, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Paolo Serafini, Jennifer Vella, Vincenzo Bronte, Pirouz Daftarian, Angel Kaifer, Serena Zilio
  • Dendrimer conjugates for coating cells
    Patent number: 11253602
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: February 22, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
  • METHODS FOR ELICITING SELECTIVE HUMORAL RESPONSES
    Publication number: 20220023421
    Abstract: Conjugates of synthetic nanocarriers, complexed with syngeneic (self) proteins adducted with haptens or other poorly immunogenic antigens (antigens of low immunogenicity), elicit selective humoral responses or antibodies against the hapten or antigen and not to self-protein. Compositions include these conjugates, which can be used as vaccines. Methods of making and using them are described herein. In a typical embodiment, a conjugate including a hapten or antigen of low immunogenicity associated with a particular disease (e.g., infection, cancer) can be used as a vaccine by eliciting antibodies that specifically neutralize the hapten or antigen. These hapten (and other poorly immunogenic antigen)-carrying nanocarriers selectively target antigen presenting cells resulting in a strong anti-hapten humoral response, and thus find use in vaccines for cancer (e.g., cancers of lung, cervix, breast, brain, liver pancreas, ovaries, skin, etc.
    Type: Application
    Filed: August 17, 2021
    Publication date: January 27, 2022
    Applicant: University of Miami
    Inventors: Victor L. Perez Quinones, Pirouz Daftarian
  • NANOPARTICLE CONJUGATES AND USES THEREOF
    Publication number: 20200237928
    Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a cell.
    Type: Application
    Filed: February 17, 2020
    Publication date: July 30, 2020
    Inventors: Paolo Serafini, Jennifer Vella, Vincenzo Bronte, Pirouz Daftarian, Angel Kaifer, Serena Zilio
  • DENDRIMER CONJUGATES FOR COATING CELLS
    Publication number: 20200085962
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 19, 2020
    Inventors: Omaida VELAZQUEZ, Sylvia DAUNERT, Pirouz DAFTARIAN, Zhao-Jun LIU, Sapna DEO
  • Nanoparticle conjugates and uses thereof
    Patent number: 10561741
    Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: February 18, 2020
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Paolo Serafini, Jennifer Vella, Vincenzo Bronte, Pirouz Daftarian, Angel Kaifer, Serena Zilio
  • Dendrimer conjugates for coating cells
    Patent number: 10493163
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 3, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
  • COMPOSITIONS FOR SELECTIVE HUMORAL RESPONSES AND METHODS OF USE THEREOF
    Publication number: 20190184013
    Abstract: Conjugates of synthetic nanocarriers, complexed with syngeneic (self) proteins adducted with haptens or other poorly immunogenic antigens (antigens of low immunogenicity), elicit selective humoral responses or antibodies against the hapten or antigen and not to self-protein. Compositions include these conjugates, which can be used as vaccines. Methods of making and using them are described herein. In a typical embodiment, a conjugate including a hapten or antigen of low immunogenicity associated with a particular disease (e.g., infection, cancer) can be used as a vaccine by eliciting antibodies that specifically neutralize the hapten or antigen. These hapten (and other poorly immunogenic antigen)-carrying nanocarriers selectively target antigen presenting cells resulting in a strong anti-hapten humoral response, and thus find use in vaccines for cancer (e.g., cancers of lung, cervix, breast, brain, liver pancreas, ovaries, skin, etc.
    Type: Application
    Filed: May 23, 2017
    Publication date: June 20, 2019
    Inventors: Victor L. Perez Quinones, Pirouz Daftarian
  • NANOPARTICLE CONJUGATES AND USES THEREOF
    Publication number: 20180243443
    Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.
    Type: Application
    Filed: March 3, 2016
    Publication date: August 30, 2018
    Inventors: Paolo Serafini, Jennifer Vella, Vicenzo Bronte, Pirouz Daftarian, Angel Kaifer, Serena Zilio
  • Dendrimer Conjugates for Coating Cells
    Publication number: 20180050111
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Application
    Filed: June 30, 2017
    Publication date: February 22, 2018
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
  • Dendrimer conjugates for coating cells
    Patent number: 9737611
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: August 22, 2017
    Assignee: University of Miami
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
  • Dendrimer Conjugates for Coating Cells
    Publication number: 20150139904
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Application
    Filed: May 21, 2013
    Publication date: May 21, 2015
    Applicant: University of Miami
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Liu Zhao-Jun, Sapna Deo