Patents by Inventor Pius Spielhofer

Pius Spielhofer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins
    Patent number: 8158416
    Abstract: The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 17, 2012
    Assignee: Crucell Switzerland AG
    Inventors: Martin A. Billeter, Pius Spielhofer, Karin Kalin, Frank Radecke, Henriette Schneider
  • CDNA Corresponding to the Antigenome of Nonsegmented Negative Stranded RNA Viruses and Process for the Production of Such Viruses
    Publication number: 20120003264
    Abstract: The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
    Type: Application
    Filed: July 1, 2011
    Publication date: January 5, 2012
    Applicant: CRUCELL SWITZERLAND AG
    Inventors: Martin A. Billeter, Pius Spielhofer, Karin Kälin, Frank Radecke, Henriette Schneider
  • cDNA corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses
    Patent number: 7993924
    Abstract: The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: August 9, 2011
    Assignee: Crucell Switzerland AG
    Inventors: Martin A. Billeter, Pius Spielhofer, Karin Kälin, Frank Radecke, Henriette Schneider
  • Infectious recombinant paramyxovirus from antigenomic cDNA
    Patent number: 7851214
    Abstract: The present invention relates, in general, to a methodology or the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: December 14, 2010
    Assignee: Crucell Switzerland AG
    Inventors: Martin A. Billeter, Pius Spielhofer, Karin Kälin, Frank Radecke, Henriette Schneider
  • Host cells comprising cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, further encoding antigenically active proteins
    Patent number: 7402429
    Abstract: The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 22, 2008
    Assignee: Schweiz Serum & Impfinstitut Bern
    Inventors: Martin A. Billeter, Pius Spielhofer, Karin Kälin, Frank Radecke, Henriette Schneider
  • cDNA Corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses
    Publication number: 20080124803
    Abstract: The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
    Type: Application
    Filed: September 6, 2007
    Publication date: May 29, 2008
    Applicant: Crucell Holland B.V.
    Inventors: Martin A. Billeter, Pius Spielhofer, Karin Kalin, Frank Radecke, Henriette Schneider
  • cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses and process for the production of such viruses
    Publication number: 20070280961
    Abstract: The present invention relates, in general, to a methodology or the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
    Type: Application
    Filed: December 27, 2005
    Publication date: December 6, 2007
    Applicant: Schweiz. Serum & Impfinstitut Bern
    Inventors: Martin Billeter, Pius Spielhofer, Karin Kalin, Frank Radecke, Henriette Schneider