Abstract: A hybrid, optimized exchange is provided, the hybrid, optimized exchange operably connected to a demand-side platform (DSP), the hybrid, optimized exchange further operably connected to a supply-side platform (SSP), the hybrid, optimized exchange configured to receive an advertising request, the hybrid, optimized exchange further configured to conduct, using a bid floor, a hybrid, optimized DSP auction of the advertising request among a plurality of DSPs, thereby generating a winning DSP that makes a winning DSP bid in an automated advertising auction system after the SSP initiates an SSP auction of the advertising request, the hybrid, optimized exchange optimizing the bid floor provided to the plurality of DSPs in the hybrid, optimized DSP auction and simultaneously optimizing a shading factor used by the hybrid, optimized exchange to place a hybrid, optimized bid on behalf of the winning DSP in the SSP auction.

Abstract: The demand-side platform (DSP) is a technological ingredient that fits into the larger real-time-bidding (RTB) ecosystem. DSPs enable advertisers to purchase ad impressions from a wide range of ad slots, generally via a second-price auction mechanism. In this aspect, predicting the auction winning price notably enhances the decision for placing the right bid value to win the auction and helps with the advertiser's campaign planning and traffic reallocation between campaigns. This is a difficult task because the observed winning price distribution is biased due to censorship; the DSP only observes the win price in the case of winning the auction. For losing bids, the win price remains censored. In this invention, we generalize the winning price model to incorporate a gradient boosting framework adapted to learn from both observed and censored data. This yields a boost in predictive performance in comparison to classic linear censored regression.

Abstract: The demand-side platform (DSP) is a technological ingredient that fits into the larger real-time-bidding (RTB) ecosystem. DSPs enable advertisers to purchase ad impressions from a wide range of ad slots, generally via a second-price auction mechanism. In this aspect, predicting the auction winning price notably enhances the decision for placing the right bid value to win the auction and helps with the advertiser's campaign planning and traffic reallocation between campaigns. This is a difficult task because the observed winning price distribution is biased due to censorship; the DSP only observes the win price in the case of winning the auction. For losing bids, the win price remains censored. In this invention, we generalize the winning price model to incorporate a gradient boosting framework adapted to learn from both observed and censored data. This yields a boost in predictive performance in comparison to classic linear censored regression.

Abstract: A hybrid, optimized exchange is provided, the hybrid, optimized exchange operably connected to a demand-side platform (DSP), the hybrid, optimized exchange further operably connected to a supply-side platform (SSP), the hybrid, optimized exchange configured to receive an advertising request, the hybrid, optimized exchange further configured to conduct, using a bid floor, a hybrid, optimized DSP auction of the advertising request among a plurality of DSPs, thereby generating a winning DSP that makes a winning DSP bid in an automated advertising auction system after the SSP initiates an SSP auction of the advertising request, the hybrid, optimized exchange optimizing the bid floor provided to the plurality of DSPs in the hybrid, optimized DSP auction and simultaneously optimizing a shading factor used by the hybrid, optimized exchange to place a hybrid, optimized bid on behalf of the winning DSP in the SSP auction.

Abstract: A hybrid, optimized exchange is provided, the hybrid, optimized exchange operably connected to a demand-side platform (DSP), the hybrid, optimized exchange further operably connected to a supply-side platform (SSP), the hybrid, optimized exchange configured to receive an advertising request, the hybrid, optimized exchange further configured to conduct, using a bid floor, a hybrid, optimized DSP auction of the advertising request among a plurality of DSPs, thereby generating a winning DSP that makes a winning DSP bid in an automated advertising auction system after the SSP initiates an SSP auction of the advertising request, the hybrid, optimized exchange optimizing the bid floor provided to the plurality of DSPs in the hybrid, optimized DSP auction and simultaneously optimizing a shading factor used by the hybrid, optimized exchange to place a hybrid, optimized bid on behalf of the winning DSP in the SSP auction.

Abstract: The demand-side platform (DSP) is a technological ingredient that fits into the larger real-time-bidding (RTB) ecosystem. DSPs enable advertisers to purchase ad impressions from a wide range of ad slots, generally via a second-price auction mechanism. In this aspect, predicting the auction winning price notably enhances the decision for placing the right bid value to win the auction and helps with the advertiser's campaign planning and traffic reallocation between campaigns. This is a difficult task because the observed winning price distribution is biased due to censorship; the DSP only observes the win price in the case of winning the auction. For losing bids, the win price remains censored. In this invention, we generalize the winning price model to incorporate a gradient boosting framework adapted to learn from both observed and censored data. This yields a boost in predictive performance in comparison to classic linear censored regression.

Abstract: A typhoid vaccine using heat shock protein (Hsp) of Salmonella typhi and a method for the manufacture thereof. A composition comprising an effective amount of a complex of a Hsp, in part or whole, either alone or covalently or non-covalently bound to an antigenic molecule, which when administered to a mammal elicits specific immunological responses in the host. The antigenic molecule refers to the exogenous antigens/immunogens such as viz LPS, peptide, nucleic acid or polysaccharide or antigenic/immunogenic fragments and derivatives thereof.

Abstract: A typhoid vaccine using heat shock protein (Hsp) of Salmonella typhi and a method for the manufacture thereof. A method of administering a composition comprising an effective amount of a complex consisting of a Hsp, in part or whole, either alone or covalently or non-covalently bound to an antigenic molecule, which when administered elicits specific immunological responses in the host is also describe. The Antigenic molecule refers to the exogenous antigens/immunogens viz LPS, peptide, nucleic acid or polysaccharide or antigenic/immunogenic fragments and derivatives thereof.