Patents by Inventor PJ Anand
PJ Anand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10675438Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.Type: GrantFiled: November 14, 2018Date of Patent: June 9, 2020Assignee: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
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Patent number: 10668247Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.Type: GrantFiled: November 14, 2018Date of Patent: June 2, 2020Assignee: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
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Patent number: 10653442Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: GrantFiled: December 21, 2017Date of Patent: May 19, 2020Assignee: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl, Ayesha Arzumand, Stela Moura
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Publication number: 20200101275Abstract: Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.Type: ApplicationFiled: September 13, 2019Publication date: April 2, 2020Applicant: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Andrew East
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Publication number: 20200101239Abstract: Methods and devices are disclosed herein that generally provide protection for devices (e.g., microcatheters) having small tips. Methods and devices are also disclosed herein that generally facilitate use of commercially-available stereotactic systems with devices (e.g., microcatheters) having small tips.Type: ApplicationFiled: October 1, 2019Publication date: April 2, 2020Inventors: Deep Arjun Singh, PJ Anand
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Publication number: 20200061337Abstract: Fluid delivery systems and methods of delivering an agent and treating a disorder are disclosed that include a subcutaneously implantable port having a body defining a chamber with an open top and a delivery opening and a septum coupled to the body to extend over the open top of the chamber. The systems and methods can further include an intrathecal catheter having an proximal end configured to be coupled to the port and fluidly coupled to the delivery opening of the chamber and a plug having a body with a passage to receive the intrathecal catheter therethrough. The plug can be configured to be inserted into the fascia to protect against leakage of cerebrospinal fluid.Type: ApplicationFiled: August 27, 2018Publication date: February 27, 2020Inventors: Deep Arjun Singh, Jonathan Freund, PJ Anand, Thomas T. Washburn, Andrew William East, Elsa Chi Abruzzo
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Publication number: 20200061362Abstract: Fluid delivery systems and methods of delivering a therapeutic agent are disclosed that include a subcutaneously implantable port that can be easily and efficiently located through the tissue of a patient. The port includes a body that defines a chamber having an open top, a delivery opening, and a catheter connection portion, and a septum disposed on the body, where the septum includes a lower surface extending over the open top of the chamber and an opposite, upper surface. The port further includes a cap of the port that defines an opening extending therethrough and the cap is configured to be coupled to the body to secure the septum within the port with the opening of the cap providing needle access to the septum. The cap includes a downwardly tapered surface that extends around the opening and is configured to direct a needle towards the upper surface of the septum.Type: ApplicationFiled: August 27, 2018Publication date: February 27, 2020Inventors: Deep Arjun Singh, Jonathan Freund, PJ Anand, Thomas T. Washburn, Andrew William East, Elsa Chi Abruzzo
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Publication number: 20190374715Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: August 21, 2019Publication date: December 12, 2019Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
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Patent number: 10493249Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: GrantFiled: July 20, 2017Date of Patent: December 3, 2019Assignee: Anuncia, Inc.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20190344046Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: July 26, 2019Publication date: November 14, 2019Inventors: Deep Arjun Singh, PJ Anand, Blake Sama
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Publication number: 20190314574Abstract: Percutaneous therapy or drug delivery devices are described herein. The device can include one or multiple lumens inside a cannula or catheter body. The device can include features for reducing or preventing backflow or reflux of infusate along the device insertion track, such as one or more bullet noses, over tubes, and/or micro-tips. The device can be used in any of a variety of treatment methods, including to inject cancer therapy medicinal products directly into pulmonary tumors or tumors located in other regions of the body. The device can include features to keep the distal tip secure during patient respiration or during other patient movement, and can reduce the incidence of reflux during therapy delivery.Type: ApplicationFiled: February 27, 2019Publication date: October 17, 2019Inventors: Katelyn Perkins-Neaton, Gregory Eberl, Morgan Brophy, Andrew East, PJ Anand, Deep Arjun Singh, Loredana Guseila, Jon Freund, Derek Peter
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Patent number: 10441770Abstract: Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.Type: GrantFiled: July 31, 2014Date of Patent: October 15, 2019Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Andrew East
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Patent number: 10434251Abstract: The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.Type: GrantFiled: August 1, 2012Date of Patent: October 8, 2019Assignee: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Deep Arjun Singh
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Patent number: 10406285Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: GrantFiled: May 25, 2017Date of Patent: September 10, 2019Assignee: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
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Publication number: 20190255284Abstract: Catheters, catheter ports, connectors, and related methods are disclosed herein, e.g., for drug delivery to a subject. The catheters and catheter ports can include various features to facilitate dosing protocols that require multiple injections, and/or for reducing or eliminating damage that may occur to the catheter, port, or patient tissue as a result of multiple injections.Type: ApplicationFiled: February 21, 2019Publication date: August 22, 2019Inventors: Jonathan Freund, PJ Anand, Deep Arjun Singh, Gregory Eberl
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Publication number: 20190160254Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: November 15, 2018Publication date: May 30, 2019Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl, Ayesha Arzumand, Stela Moura, Andrew East, Jonathan Freund
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Publication number: 20190143038Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.Type: ApplicationFiled: November 14, 2018Publication date: May 16, 2019Inventors: Pj Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
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Publication number: 20190143037Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.Type: ApplicationFiled: November 14, 2018Publication date: May 16, 2019Inventors: PJ Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
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Publication number: 20190117886Abstract: The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.Type: ApplicationFiled: November 13, 2018Publication date: April 25, 2019Inventor: PJ Anand
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Publication number: 20190009055Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: August 31, 2018Publication date: January 10, 2019Applicant: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Blake Sama