Abstract: The present invention relates to a method for reducing an effective amount of Bevacizumab required for treating brain tumor. The present invention also provides a kit used for the aforesaid method. The present method adopts a combination strategy to combine Bevacizumab treatment with ultrasound exposure, which comprises at least the following steps: administering Bevacizumab to a subject; administering an ultrasound-response medium to said subject; and administering said subject with an ultrasound exposure. Specific effective amount of the Bevacizumab treatment and the ultrasound exposure were identified. The efficacy of conventional Bevacizumab treatment is significantly improved.

Abstract: Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.

Abstract: Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.

Abstract: A method for measuring the amount of material removed from a target in pulsed laser ablation is provided. The method includes generating a laser beam with a laser generator for ablating the target; driving the laser generator with a delay generator; acquiring the acoustic signal generated when the target is being ablated by the laser beam and generating an electrical signal accordingly with a microphone; amplifying the electrical signal generated by the microphone with a pre-amplifier; displaying an acoustic waveform indicating the intensity of the acoustic signal generated when the target is being ablated by the laser beam with a digital oscilloscope connected to the delay generator and the pre-amplifier; and deducing the amount of material removed from the target in the pulsed laser ablation according to the acoustic waveform in real time. An apparatus for performing the method is also provided.

Abstract: A method for measuring the amount of material removed from a target in pulsed laser ablation is provided. The method includes generating a laser beam with a laser generator for ablating the target; driving the laser generator with a delay generator; acquiring the acoustic signal generated when the target is being ablated by the laser beam and generating an electrical signal accordingly with a microphone; amplifying the electrical signal generated by the microphone with a pre-amplifier; displaying an acoustic waveform indicating the intensity of the acoustic signal generated when the target is being ablated by the laser beam with a digital oscilloscope connected to the delay generator and the pre-amplifier; and deducing the amount of material removed from the target in the pulsed laser ablation according to the acoustic waveform in real time. An apparatus for performing the method is also provided.