Abstract: A travel smart collision avoidance warning system is provided, comprising a plurality of mobile devices and a positioning device. Each mobile device is provided with an application program downloaded by a corresponding user. The positioning device is coupled to the application so as to store location information of the mobile devices. Each mobile device comprises a processing unit for the corresponding user to pre-set a detection range of the mobile device and an indicating unit. The processing unit is coupled to the positioning device and calculates whether the other mobile devices will be encountered in a pre-set time according to location information, detection range, and traveling speed of the mobile device. If any of the other mobile devices enter a warning range within the pre-set time, the indicating unit is triggered to provide a warning signal so as to make travel much more brilliant and safe.