Patents by Inventor Poncho Meisenheimer

Poncho Meisenheimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bioluminescent detection of cyanohydroxy benzothiazole compounds
    Patent number: 8551721
    Abstract: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. Also provided are novel compounds that can be used in the methods. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: October 8, 2013
    Assignee: Promega Corporation
    Inventors: Jessica Anderson, Poncho Meisenheimer, John Shultz, James J. Cali, Dongping Ma
  • Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
    Patent number: 8476450
    Abstract: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: July 2, 2013
    Assignee: Promega Corporation
    Inventors: James J. Cali, William Daily, Erika Hawkins, Dieter Klaubert, Jianquan Liu, Poncho Meisenheimer, Michael Scurria, John Shultz, James Unch, Michael P. Valley, Keith V. Wood, Wenhui Zhou
  • Luminogenic compounds and methods to detect cytochrome P450 3A enzymes
    Patent number: 8288559
    Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: October 16, 2012
    Assignee: Promega Corporation
    Inventors: Cesear Corona, Poncho Meisenheimer, Harry Tetsuo Uyeda
  • NOVEL COELENTERAZINE SUBSTRATES AND METHODS OF USE
    Publication number: 20120117667
    Abstract: An isolated polynucleotide encoding a modified luciferase polypeptide and novel coelenterazine-based substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.
    Type: Application
    Filed: November 2, 2011
    Publication date: May 10, 2012
    Inventors: Dieter H. Klaubert, Poncho Meisenheimer, James Unch
  • COELENTERAZINE DERIVATIVES AND METHODS OF USING SAME
    Publication number: 20120107849
    Abstract: The invention provides coelenterazine derivatives which are substrates for a non-luminescent enzyme and a pro-substrate for a luminescent enzyme. The invention also provides a method of using the derivatives.
    Type: Application
    Filed: November 2, 2011
    Publication date: May 3, 2012
    Inventors: Dieter H. Klaubert, Poncho Meisenheimer, James Unch, Wenhui Zhou
  • BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS
    Publication number: 20110223625
    Abstract: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.
    Type: Application
    Filed: March 11, 2011
    Publication date: September 15, 2011
    Applicant: PROMEGA CORPORATION
    Inventors: Jessica Kelts, Poncho Meisenheimer, John Shultz, James J. Cali, Dongping Ma
  • Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
    Patent number: 7951550
    Abstract: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: May 31, 2011
    Assignee: Promega Corporation
    Inventors: James J. Cali, William Daily, Erika Hawkins, Dieter Klaubert, Jianquan Liu, Poncho Meisenheimer, Michael Scurria, John W. Shultz, James Unch, Michael P. Valley, Keith V. Wood, Wenhui Zhou
  • BIOLUMINESCENT DETECTION OF CYANOHYDROXY BENZOTHIAZOLE COMPOUNDS
    Publication number: 20100075351
    Abstract: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. Also provided are novel compounds that can be used in the methods. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.
    Type: Application
    Filed: September 9, 2009
    Publication date: March 25, 2010
    Applicant: Promega Corporation
    Inventors: Jessica Anderson, Poncho Meisenheimer, John Shultz, James J. Cali, Dongping Ma
  • LUMINOGENIC COMPOUNDS AND METHODS TO DETECT CYTOCHROME P450 3A ENZYMES
    Publication number: 20100062470
    Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.
    Type: Application
    Filed: August 18, 2009
    Publication date: March 11, 2010
    Applicant: Promega Corporation
    Inventors: Cesear Corona, Poncho Meisenheimer, Harry Tetsuo Uyeda
  • Protein labeling with cyanobenzothiazole conjugates
    Publication number: 20090263843
    Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.
    Type: Application
    Filed: March 26, 2009
    Publication date: October 22, 2009
    Applicant: Promega Corporation
    Inventors: Jessica Anderson, Poncho Meisenheimer, John Shultz
  • Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
    Publication number: 20080299593
    Abstract: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
    Type: Application
    Filed: July 3, 2008
    Publication date: December 4, 2008
    Applicant: Promega Corporation
    Inventors: James J. Cali, William Daily, Erika Hawkins, Dieter Klaubert, Jianquan Liu, Poncho Meisenheimer, Michael Scurria, John W. Shultz, James Unch, Michael P. Valley, Keith V. Wood, Wenhui Zhou
  • Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
    Publication number: 20070015790
    Abstract: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
    Type: Application
    Filed: May 31, 2006
    Publication date: January 18, 2007
    Inventors: James Cali, William Daily, Erika Hawkins, Dieter Klaubert, Jianquan Liu, Poncho Meisenheimer, Michael Scurria, John Shultz, James Unch, Michael Valley, Keith Wood, Wenhui Zhou