Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: A system for dynamically balancing power in a battery pack during charging and discharging includes a battery pack, a control unit, and a load unit. The battery pack includes one or more modules. Each module includes one or more bricks. Each brick includes one or more blocks connected either in a series configuration or in a parallel configuration. Each block includes one or more cells. The control unit is connected with the battery pack across each of the blocks for processing power from each of the blocks irrespective of a power mismatch between the blocks. The control unit dynamically balances the power in the battery pack by controlling a differential current from a block with higher state of charge (SOC) to a block of lower SOC, using one or more converters and thereby maximizing available energy of the battery pack during charging and discharging.

Abstract: A battery management system for dynamically balancing power in a battery module is provided. The battery management system comprises a plurality of modules, and each of the plurality of modules comprises a plurality of bricks. Each of the plurality of bricks comprises a plurality of blocks, electrically connected in one of a series configuration or a parallel configuration and a controller assembly provided in each of the plurality of the modules. The controller assembly comprises a first converter adapted to be connected to the plurality of bricks and a second converter adapted to be connected to an external system. The controller assembly is configured to obtain a plurality of battery pack parameters from the plurality of bricks using the first converter, process the obtained plurality of battery pack parameters and determine a current level to regulate a charging or discharging of the battery pack using the second converter.

Abstract: A system for dynamically balancing power in a battery pack during charging and discharging includes a battery pack, a control unit, and a load unit. The battery pack includes one or more modules. Each module includes one or more bricks. Each brick includes one or more blocks connected either in a series configuration or in a parallel configuration. Each block includes one or more cells. The control unit is connected with the battery pack across each of the blocks for processing power from each of the blocks irrespective of a power mismatch between the blocks. The control unit dynamically balances the power in the battery pack by controlling a differential current from a block with higher state of charge (SOC) to a block of lower SOC, using one or more converters and thereby maximizing available energy of the battery pack during charging and discharging.

Abstract: An isolated antigen-binding protein characterised in that it is capable of binding specifically to human Arginase II (ARG2) and inhibiting the enzyme activity of human ARG2.

Abstract: One example provides a system for dynamically balancing power in a battery pack during charging and discharging. The system includes a battery pack, a control unit, and a load unit. The battery pack includes one or more modules. Each module includes one or more bricks. Each brick includes one or more blocks connected either in a series configuration or in a parallel configuration. Each block includes one or more cells. The control unit is connected with the battery pack across each of the blocks for processing power from each of the blocks irrespective of a power mismatch between the blocks. The control unit dynamically balances the power in the battery pack by controlling a differential current from a block with higher state of charge (SOC) to a block of lower SOC, using one or more converters and thereby maximizing available energy of the battery pack during charging and discharging.

Abstract: The invention relates to novel heterocyclic compounds of Formula (I) which inhibit necroptosis and methods for their use. The compounds may be useful in the treatment of conditions associated with deregulated necroptosis.

Abstract: The present invention relates to methods for inhibiting necroptosis; screening methods for identifying compounds which inhibit necroptosis; and compounds for the inhibition of necroptosis, which may be useful in the treatment of conditions associated with deregulated necroptosis.

Abstract: A method and apparatus for performing mitral valve chordal repair on a patient include attaching at least one filament to a mitral valve leaflet and to a papillary muscle. A first end of a filament can be attached to the mitral valve leaflet and the length of the filament can be adjusted by adjusting the tension of the filament in a catheter. The second end of the filament can be attached to an attachment site.

Abstract: The present invention provides a process for the preparation of nanowires of metal oxides with dopant elements in lower valence state. The nanomaterials/materials with dopants in lower valence state are important as these exhibit markedly different characteristics than higher valence state materials of same composition. Nanowires show markedly enhanced properties in lateral direction. The invented process presents a procedure for preparation of different types of nanowires in oxide form that are useful for different applications. In this a precursor is ignited in a specially designed container/enclosure that produces the product with the described features. The process is simple and involves a single step/stage is of very short time per batch. The invention provides a process, which gives controlled size of nanowires and is suitable for the production of nanowires/nanomaterials of desired metal oxides with dopant elements in valence state.

Abstract: A method and apparatus for performing mitral valve chordal repair on a patient include attaching at least one filament to a mitral valve leaflet and to a papillary muscle. A first end of a filament can be attached to the mitral valve leaflet and the length of the filament can be adjusted by adjusting the tension of the filament in a catheter. The second end of the filament can be attached to an attachment site.

Abstract: The present invention provides a process for the preparation of nanowires of metal oxides with dopant elements in lower valence state. The nanomaterials/materials with dopants in lower valence state are important as these exhibit markedly different characteristics than higher valence state materials of same composition. Nanowires show markedly enhanced properties in lateral direction. The invented process presents a procedure for preparation of different types of nanowires in oxide form that are useful for different applications. In this a precursor is ignited in a specially designed container/enclosure that produces the product with the described features. The process is simple and involves a single step/stage is of very short time per batch. The invention provides a process, which gives controlled size of nanowires and is suitable for the production of nanowires/nanomaterials of desired metal oxides with dopant elements in valence state.