Patents by Inventor Poonsakdi Ploypradith

Poonsakdi Ploypradith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
    Patent number: 6160004
    Abstract: The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes; or when n is 3, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: December 12, 2000
    Assignees: Hauser, Inc., Johns Hopkins University
    Inventors: Gary H. Posner, Soon Hyung Woo, Poonsakdi Ploypradith, Michael H. Parker, Theresa A. Shapiro, Jeffrey S. Elias, John Northrop, Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh
  • C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
    Patent number: 6156790
    Abstract: The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: December 5, 2000
    Assignees: Hauser, Inc., Johns Hopkins University
    Inventors: Gary H. Posner, Soon Hyung Woo, Poonsakdi Ploypradith, Michael H. Parker, Theresa A. Shapiro, Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh
  • Trioxane dimer compounds having antiproliferative and antitumor activities
    Patent number: 6004997
    Abstract: Novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: December 21, 1999
    Assignees: Hauser, Inc., Johns Hopkins University
    Inventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner
  • Trioxane dimer compounds having antiproliferative and antitumor activities
    Patent number: 5840925
    Abstract: Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: November 24, 1998
    Assignee: Hauser, Inc.
    Inventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner
  • Trioxane dimer compound having antiproliferative and antitumor activities
    Patent number: RE38117
    Abstract: Described herein are novel trioxane dimers of structure which possess antiproliferative and antitumor activities.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: May 6, 2003
    Assignees: Hauser, Inc., Johns Hopkins
    Inventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner