Patents by Inventor Pottayil Govindan N. Sasikumar

Pottayil Govindan N. Sasikumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORMS OF 3-SUBSTITUTED 1,2,4- OXADIAZOLE
    Publication number: 20230278970
    Abstract: The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
    Type: Application
    Filed: May 15, 2023
    Publication date: September 7, 2023
    Inventors: Pottayil Govindan N. Sasikumar, Seetharamaiah Setty S. Naremaddepalli
  • Crystalline forms of 3-substituted 1,2,4-oxadiazole
    Patent number: 11680051
    Abstract: The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: June 20, 2023
    Assignee: Aurigene Discovery Technologies Limited
    Inventors: Pottayil Govindan N. Sasikumar, Seetharamaiah Setty S. Naremaddepalli
  • 1,2,4-Oxadiazole and Thiadiazole Compounds as Immunomodulators
    Publication number: 20230110077
    Abstract: The present invention relates to 1,2,4-oxadiazole and thiadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
    Type: Application
    Filed: October 10, 2022
    Publication date: April 13, 2023
    Applicant: Aurigene Discovery Technologies Limited
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty Sudarshan Naremaddepalli
  • CONJOINT THERAPIES FOR IMMUNOMODULATION
    Publication number: 20230081191
    Abstract: The present disclosure relates to methods comprising administering compounds that inhibit VISTA and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways with a compound that inhibits TIM-3 and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by VISTA, TIM-3, PD-1, PD-L1, and/or PD-L2.
    Type: Application
    Filed: October 5, 2022
    Publication date: March 16, 2023
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Raghuveer K. Ramachandra, Adam S. Lazorchak, Timothy L. Wyant
  • DUAL INHIBITORS OF TIM-3 AND PD-1 PATHWAYS
    Publication number: 20230062570
    Abstract: The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by TIM-3, PD-1, PD-L1, and/or PD-L2.
    Type: Application
    Filed: October 7, 2022
    Publication date: March 2, 2023
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty S. Naremaddepalli, Nagaraj Gowda
  • Conjoint therapies for immunomodulation
    Patent number: 11497735
    Abstract: The present disclosure relates to methods comprising administering compounds that inhibit VISTA and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways with a compound that inhibits TIM-3 and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by VISTA, TIM-3, PD-1, PD-L1, and/or PD-L2.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: November 15, 2022
    Assignees: Aurigene Discovery Technologies Limited, Curis, Inc.
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Raghuveer K. Ramachandra, Adam S. Lazorchak, Timothy L. Wyant
  • Dual inhibitors of TIM-3 and PD-1 pathways
    Patent number: 11497734
    Abstract: The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by TIM-3, PD-1, PD-L1, and/or PD-L2.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: November 15, 2022
    Assignee: Aurigene Discovery Technologies Limited
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty S. Naremaddepalli, Nagaraj Gowda
  • 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
    Patent number: 11465976
    Abstract: The present invention relates to 1,2,4-oxadiazole and thiadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
    Type: Grant
    Filed: August 1, 2020
    Date of Patent: October 11, 2022
    Assignee: Aurigene Discovery Technologies Limited
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty Sudarshan Naremaddepalli
  • CRYSTALLINE FORMS OF 3-SUBSTITUTED 1,2,4- OXADIAZOLE
    Publication number: 20220048875
    Abstract: The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
    Type: Application
    Filed: August 30, 2021
    Publication date: February 17, 2022
    Inventors: Pottayil Govindan N. Sasikumar, Seetharamaiah Setty S. Naremaddepalli
  • Crystalline forms of 3-substituted 1,2,4-oxadiazole
    Patent number: 11136300
    Abstract: The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: October 5, 2021
    Assignee: Aurigene Discovery Technologies Limited
    Inventors: Pottayil Govindan N. Sasikumar, Seetharamaiah Setty S. Naremaddepalli
  • DUAL INHIBITORS OF TIM-3 AND PD-1 PATHWAYS
    Publication number: 20200368210
    Abstract: The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by TIM-3, PD-1, PD-L1, and/or PD-L2.
    Type: Application
    Filed: October 31, 2018
    Publication date: November 26, 2020
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Sethy S. Naremaddepalli, Nagaraj Gowda
  • 1,2,4-Oxadiazole and Thiadiazole Compounds as Immunomodulators
    Publication number: 20200361880
    Abstract: The present invention relates to 1,2,4-oxadiazole and thiadiazole compounds of formula (1) and their use to inhibit the programmed cell death 1 (PD1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
    Type: Application
    Filed: August 1, 2020
    Publication date: November 19, 2020
    Applicant: Aurigene Discovery Technologies Limited
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty Sudarshan Naremaddepalli
  • CONJOINT THERAPIES FOR IMMUNOMODULATION
    Publication number: 20200289477
    Abstract: The present disclosure relates to methods comprising administering compounds that inhibit VISTA and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways with a compound that inhibits TIM-3 and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by VISTA, TIM-3, PD-1, PD-L1, and/or PD-L2.
    Type: Application
    Filed: October 31, 2018
    Publication date: September 17, 2020
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Raghuveer K. Ramachandra, Adam S. Lazorchak, Timothy L. Wyant
  • CRYSTALLINE FORMS OF 3-SUBSTITUTED 1,2,4- OXADIAZOLE
    Publication number: 20200239422
    Abstract: The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
    Type: Application
    Filed: October 10, 2018
    Publication date: July 30, 2020
    Inventors: Pottayil Govindan N. Sasikumar, Seetharamaiah Setty S. Naremaddepalli
  • DUAL INHIBITORS OF VISTA AND PD-1 PATHWAYS
    Publication number: 20200061030
    Abstract: The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as V-domain immunoglobulin suppressor of T-cell activation (VISTA) inhibitors or as dual inhibitors of VISTA and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by VISTA and its ligands, PD-1, PD-L1, and/or PD-L2.
    Type: Application
    Filed: October 18, 2017
    Publication date: February 27, 2020
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty S. Naremaddepalli
  • 1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS
    Publication number: 20180044303
    Abstract: The present invention relates to 1,2,4-oxadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD-1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
    Type: Application
    Filed: March 7, 2016
    Publication date: February 15, 2018
    Inventors: Pottayil Govindan N. Sasikumar, Muralidhara Ramachandra, Seetharamaiah Sudarshan Naremaddepalli