Patents by Inventor Prabakaran Mookkan

Prabakaran Mookkan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monovalent H5 vaccine
    Patent number: 9694067
    Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: July 4, 2017
    Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Fang He, Hwei-Sing Jimmy Kwang, Prabakaran Mookkan
  • Universal vaccine against H5N1 lineages
    Patent number: 9555093
    Abstract: The present invention relates to a universal H5N1 vaccine. More specifically, the present invention relates to the identification of three H5N1 strains which cover the entire variants in the neutralizing epitopes of hemagglutinin among most H5N1 lineages. The present invention further relates a universal H5N1 vaccine that comprises the three H5N1 strains or that comprises hemagglutinin peptides of each of these three strains.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: January 31, 2017
    Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Prabakaran Mookkan, Fang He, Hwei-Sing Jimmy Kwang
  • MONOVALENT H5 VACCINE
    Publication number: 20170000877
    Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.
    Type: Application
    Filed: December 12, 2014
    Publication date: January 5, 2017
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Fang HE, Hwei-Sing Jimmy KWANG, Prabakaran MOOKKAN
  • Monoclonal antibody specific to major neutralizing epitope of influenza H5 hemagglutinin
    Patent number: 8992929
    Abstract: The present invention relates to the murine monoclonal antibody 4C2 or to chimeric or humanized monoclonal antibodies specific to a major neutralizing epitope of influenza H5 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H5N1 influenza using such murine or chimeric or humanized monoclonal antibodies or fragments thereof.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: March 31, 2015
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Prabakaran Mookkan, Fang He, Hwei-Sing Jimmy Kwang
  • Binding protein and epitope-blocking ELISA for the universal detection of H5-subtype influenza viruses
    Patent number: 8574830
    Abstract: Monoclonal antibodies and related binding proteins specific to influenza H5 subtype HA protein can be used in serological diagnosis of influenza H5 infection in mammalian and avian serum samples, including human serum samples. Each antibody reacts strongly with a wide variety of strains of H5 subtype and does not show cross-reactivity with non-H5 influenza subtypes.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: November 5, 2013
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Prabakaran Mookkan, Nayana Prabhu Padubidhri, Sumathy Velumani, Hwei-Sing Jimmy Kwang
  • Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza A viruses and uses thereof
    Patent number: 8540995
    Abstract: This invention relates to methods and products for the diagnosis, surveillance, prevention, and treatment of influenza A virus infections in animals and humans. More particularly, the invention relates to antibodies and related binding proteins for the detection, prevention and treatment of influenza A viruses. The monoclonal antibodies and related binding proteins of the invention are useful for the treatment of the highly pathogenic H5 subtypes of avian influenza virus (AIV).
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: September 24, 2013
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Prabakaran Mookkan, Nayana Prabhu Padubidhri, Sumathy Velumani, Hwei-Sing Jimmy Kwang
  • MONOCLONAL ANTIBODY SPECIFIC TO MAJOR NEUTRALIZING EPITOPE OF INFLUENZA H5 HEMAGGLUTININ
    Publication number: 20130202608
    Abstract: The present invention relates to the murine monoclonal antibody 4C2 or to chimeric or humanized monoclonal antibodies specific to a major neutralizing epitope of influenza H5 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H5N1 influenza using such murine or chimeric or humanized monoclonal antibodies or fragments thereof.
    Type: Application
    Filed: August 23, 2010
    Publication date: August 8, 2013
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Prabakaran Mookkan, Fang He, Hwei-Sing Jimmy Kwang
  • Monoclonal Antibodies Specific to the Fusion Peptide From Hemagglutinin From Influenza A Viruses and Uses Thereof
    Publication number: 20110256141
    Abstract: This invention relates to methods and products for the diagnosis, surveillance, prevention, and treatment of influenza A virus infections in animals and humans. More particularly, the invention relates to antibodies and related binding proteins for the detection, prevention and treatment of influenza A viruses. The monoclonal antibodies and related binding proteins of the invention are useful for the treatment of the highly pathogenic H5 subtypes of avian influenza virus (AIV).
    Type: Application
    Filed: December 24, 2008
    Publication date: October 20, 2011
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Prabakaran Mookkan, Nayana Prabhu Padubidhri, Sumathy Velumani, Hwei-Sing Jimmy Kwang
  • Binding Protein and Epitope-Blocking Elisa for the Universal Detection of H5-Subtype Influenza Viruses
    Publication number: 20110053142
    Abstract: Monoclonal antibodies and related binding proteins specific to influenza H5 subtype HA protein can be used in serological diagnosis of influenza H5 infection in mammalian and avian serum samples, including human serum samples. Each antibody reacts strongly with a wide variety of strains of H5 subtype and does not show cross-reactivity with non-H5 influenza subtypes.
    Type: Application
    Filed: February 5, 2008
    Publication date: March 3, 2011
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Prabakaran Mookkan, Nayana Prabhu Padubidhri, Sumathy Velumani, Hwei-Sing Jimmy Kwang