Patents by Inventor Prabha Karnachi

Prabha Karnachi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3
    Publication number: 20240124451
    Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by NLPR3. The compounds of the present invention may be useful in the treatment, prevention or management of diseases, disorders and conditions mediated by NLRP3 such as, but not limited to, gout, pseudogout, CAPS, NASH fibrosis, heart failure, idiopathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease and traumatic brain injury.
    Type: Application
    Filed: September 21, 2023
    Publication date: April 18, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Donna A.A.W. Hayes, Prabha Karnachi, Madeleine Eileen Kieffer, Kyle S. McClymont, Rohan Rajiv Merchant, Essam Metwally, Anilkumar G. Nair, Ning Qi, Jillian Rose Sanzone, Nunzio Sciammetta, Emma H. Southgate, Zheng Tan, Brandon M. Taoka
  • HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS
    Publication number: 20100279986
    Abstract: This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Inventors: Yue-Mei ZHANG, Bangping Xiang, Shyh-Ming Yang, Kenneth Rhodes, Robert Scannevin, Paul Jackson, Davraj Chakravarty, Xiaodong Fan, Lawrence J. Wilson, Prabha Karnachi
  • Heterocyclic derived metalloprotease inhibitors
    Patent number: 7803793
    Abstract: This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: September 28, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Yue-Mei Zhang, Bangping Xiang, Shyh-Ming Yang, Kenneth Rhodes, Robert Scannevin, Paul Jackson, Davraj Chakravarty, Xiaodong Fan, Lawrence J. Wilson, Prabha Karnachi
  • HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS
    Publication number: 20080103129
    Abstract: This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
    Type: Application
    Filed: September 21, 2007
    Publication date: May 1, 2008
    Inventors: Yue-Mei Zhang, Bangping Xiang, Shyh-Ming Yang, Kenneth Rhodes, Robert Scannevin, Paul Jackson, Davraj Chakravarty, Xiaodong Fan, Lawrence Wilson, Prabha Karnachi
  • MATRIX METALLOPROTEASE INHIBITORS
    Publication number: 20080085893
    Abstract: The present invention relates to compounds of Formula I, wherein R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. In addition, the present invention relates to methods treating disorders related to matrix metalloproteases. More particularly, the compounds of the present invention are useful for treating stroke.
    Type: Application
    Filed: September 24, 2007
    Publication date: April 10, 2008
    Inventors: Shyh-Ming YANG, Bingbing Wang, Robert Scannevin, Kenneth Rhodes, Bharat Lagu, Lawrence Wilson, Prabha Karnachi, William Murray
  • SUBSTITUTED PYRIMIDINYL OXIME KINASE INHIBITORS
    Publication number: 20070270425
    Abstract: The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
    Type: Application
    Filed: December 12, 2006
    Publication date: November 22, 2007
    Inventors: Guozhang Xu, Lily Lee, Terry Hughes, Steven Wetter, Peter Connolly, Marta Abad, Stuart Emanuel, Prabha Karnachi, Steven Middleton