Patents by Inventor Prabhakar K. Jadhav
Prabhakar K. Jadhav has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6489333Abstract: This invention relates to novel heterocycles which are useful as antagonists of the &agr;v&bgr;3 integrin, the &agr;2b&bgr;3 integrin, and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.Type: GrantFiled: April 9, 2001Date of Patent: December 3, 2002Assignee: Bristol - Meyers Squibb Pharma CompanyInventors: William J. Pitts, Prabhakar K. Jadhav
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Patent number: 6455560Abstract: This invention relates to novel isoxazolines of formula (I): or a pharmaceutically acceptable salt form thereof. This invention also relates to novel isoxazolines of formula (I) which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.Type: GrantFiled: July 13, 2001Date of Patent: September 24, 2002Inventors: John Wityak, Prabhakar K. Jadhav
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Publication number: 20020082253Abstract: Fibrinogen receptor antagonists of the formula: 1Type: ApplicationFiled: July 13, 2001Publication date: June 27, 2002Inventors: John Wityak, Prabhakar K. Jadhav
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Publication number: 20010044535Abstract: This invention relates to novel heterocycles which are useful as antagonists of the &agr;v&bgr;3 integrin, the &agr;2b&bgr;3 integrin, and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.Type: ApplicationFiled: April 9, 2001Publication date: November 22, 2001Inventors: William J. Pitts, Prabhakar K. Jadhav
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Patent number: 6319937Abstract: This invention relates to novel isoxazolines of formula (I): or a pharmaceutically acceptable salt form thereof. This invention also relates to novel isoxazolines of formula (I) which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.Type: GrantFiled: November 17, 1999Date of Patent: November 20, 2001Assignee: DuPont Pharmaceuticals CompanyInventors: John Wityak, Prabhakar K. Jadhav
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Patent number: 6214834Abstract: This invention relates to novel heterocycles which are useful as antagonists of the &agr;v&bgr;3 integrin and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, to iontophoretic delivery of such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.Type: GrantFiled: March 27, 1998Date of Patent: April 10, 2001Assignee: Dupont Pharmaceuticals CompanyInventors: Prabhakar K. Jadhav, Douglas G. Batt, Munir A. Hussain, William J. Pitts, Arnold J. Repta
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Patent number: 5637780Abstract: This invention relates to methods for preparing alkylating agents and use of the agents prepared. In particular, this invention relates to preparation methods for hydroxy halide and organooxy halide alkylating agents and their use for alkylating cyclic urea compounds.Type: GrantFiled: June 30, 1994Date of Patent: June 10, 1997Assignee: The DuPont Merck Pharmaceutical CompanyInventors: Prabhakar K. Jadhav, George C. Emmett, Michael E. Pierce
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Patent number: 5610294Abstract: This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: ##STR1## wherein R.sup.22 and R.sup.23 are allyl.Type: GrantFiled: February 16, 1994Date of Patent: March 11, 1997Assignee: The Du Pont Merck Pharmaceutical CompanyInventors: Patrick Y. Lam, Prabhakar K. Jadhav, Charles J. Eyermann, Carl N. Hodge, George V. De Lucca, James D. Rodgers
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Patent number: 5506355Abstract: The present invention discloses processes for the preparation of substituted cyclic sulfamides which are useful as intermediates for the synthesis of cyclic sulfamide human immunodeficiency virus (HIV) protease inhibitors. Such substituted cyclic sulfamide intermediates contain a cyclic acetal-protected diol.Type: GrantFiled: June 30, 1994Date of Patent: April 9, 1996Assignee: The Du Pont Merck Pharmaceutical CompanyInventors: Prabhakar K. Jadhav, Wayne F. Daneker, Francis J. Woerner
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Patent number: 5491149Abstract: This invention relates to substituted dihydroxypropylamines, a process to prepare intermediates useful for the synthesis of these compounds, compositions comprising such compounds, and a method of treating retroviral infection.Type: GrantFiled: August 26, 1994Date of Patent: February 13, 1996Assignee: The Du Pont Merck Pharmaceutical CompanyInventor: Prabhakar K. Jadhav
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Patent number: 5491083Abstract: Poly(fluoroalkyl) sugar reagents are prepared containing a sugar such as a monosaccharide or a disaccharide to which are bonded a plurality of fluoroalkyl anchor groups capable of attaching to a fluorocarbon surface, and either a reactive group capable of covalent coupling to a biomolecule such as an enzyme or a charged group to form an ion-exchanger or a non-ionic group to give a neutral fluorosurfactant. A spacer may be between the reactive group and the sugar. The poly(fluoroalkyl) sugar reagents are strongly adsorbed onto fluorocarbon surfaces to provide supports for such applications as separation and immobilization of biomolecules such as enzymes, carrying out heterogeneous diagnostic assays, and preparation of biosensors.Type: GrantFiled: October 5, 1994Date of Patent: February 13, 1996Assignee: E. I. Du Pont de Nemours and CompanyInventors: Rene Arentzen, Prabhakar K. Jadhav, Robert K. Kobos, Bruce E. Smart
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Patent number: 5430155Abstract: There are provided novel 1,4 Diamine 2,3 Dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.Type: GrantFiled: December 17, 1993Date of Patent: July 4, 1995Assignee: The Du Pont Merck Pharmaceutical CompanyInventors: Prabhakar K. Jadhav, Lawrence R. McGee, Ashok Shenvi, Carl N. Hodge
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Patent number: 5384254Abstract: Poly(fluoroalkyl) sugar reagents are prepared containing a sugar such as a monosaccharide or a disaccharide to which are bonded a plurality of fluoroalkyl anchor groups capable of attaching to a fluorocarbon surface, and either a reactive group capable of covalent coupling to a biomolecule such as an enzyme or a charged group to form an ion-exchanger or a non-ionic group to give a neutral fluorosurfactant. A spacer may be between the reactive group and the sugar. The poly(fluoroalkyl) sugar reagents are strongly adsorbed onto fluorocarbon surfaces to provide supports for such applications as separation and immobilization of biomolecules such as enzymes, carrying out heterogeneous diagnostic assays, and preparation of biosensors.Type: GrantFiled: May 20, 1993Date of Patent: January 24, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: Rene Arentzen, Prabhakar K. Jadhav, Robert K. Kobos, Bruce E. Smart
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Patent number: 5352811Abstract: Preparaing alkanoyloxytetradecanoic acids by asymmetric allylboration, acylation, and oxidation of homoallylic alcohols in the operational presence of a phase transfer catalyst.Type: GrantFiled: July 22, 1992Date of Patent: October 4, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventor: Prabhakar K. Jadhav
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Patent number: 5294720Abstract: There are provided novel 1,4 Diamine 2,3 Dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.Type: GrantFiled: May 31, 1991Date of Patent: March 15, 1994Assignee: The DuPont Merck Pharmaceutical Co.Inventors: Prabhakar K. Jadhav, Lawrence R. McGee, Ashok Shenvi, Carl N. Hodge
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Patent number: 5243037Abstract: Poly(fluoroalkyl) sugar reagents are prepared containing a sugar such as a monosaccharide or a disaccharide to which are bonded multiple fluoroalkyl anchor groups capable of attaching to a fluorocarbon surface, and either a reactive group capable of covalent coupling to a biomolecule or a charged group to form an ion-exchanger or a non-ionic group to give a neutral fluorosurfactant. A spacer may be between the reactive group and the sugar. The poly(fluoroalkyl) sugar reagents are strongly adsorbed onto fluorocarbon surfaces to provide supports for such applications as separation and immobilization of biomolecules such as enzymes, carrying out heterogeneous diagnostic assays, and preparation of biosensors.Type: GrantFiled: September 21, 1990Date of Patent: September 7, 1993Assignee: E. I. Du Pont de Nemours and CompanyInventors: Rene Arentzen, Prabhakar K. Jadhav, Robert K. Kobos, Bruce E. Smart
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Patent number: 5158941Abstract: This invention concerns the use of synthetic Lipid A analog P9132 to activate human monocytes, and inhibit growth of tumor cells.Type: GrantFiled: June 8, 1990Date of Patent: October 27, 1992Assignee: E. I. Du Pont de Nemours and CompanyInventors: Prabhakar K. Jadhav, Mary E. Neville, Robert C. Newton, Subramaniam Sabesan
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Patent number: 4824657Abstract: A process for reducing halogen-containing compounds of silicon, germanium or tin with lithium hydride in the presence of tetrahydrofuran wherein the lithium hydride is first heated in the tetrahydrofuran and then the halogen-containing compound is added.Type: GrantFiled: November 27, 1985Date of Patent: April 25, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventor: Prabhakar K. Jadhav
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Patent number: RE37781Abstract: This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: wherein R22 and R23 are allyl.Type: GrantFiled: March 10, 1999Date of Patent: July 2, 2002Assignee: DuPont Pharmaceuticals CompanyInventors: Patrick Y. Lam, Prabhakar K. Jadhav, Charles J. Eyermann, Carl N. Hodge, George V. De Lucca, James D. Rodgers