Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: An example system includes a vehicle having a prime mover motively coupled to a drive line; a motor/generator selectively coupled to the drive line, and configured to selectively modulate power transfer between an electrical load and the drive line; a battery pack; a DC/DC converter electrically interposed between the motor/generator and the electrical load, and between the battery pack and the electrical load, the DC/DC converter comprising a DC/DC converter housing; and a covering tray positioned over a plurality of batteries of the battery pack, the covering tray comprising a connectivity layer configured to provide electrical connectivity to terminals of the plurality of batteries.

Abstract: A firmware update system includes firmware storage device(s), an operating system engine coupled to the firmware storage device(s), and a remote access controller device coupled to the firmware storage device(s) and the operating system engine. The remote access controller device receives a single out-of-band firmware update command and, in response, performs a firmware storage device unlock operation to unlock the firmware storage device(s), transmits a firmware update package including a firmware update utility and a firmware update image to the operating system engine to cause the operating system engine to utilize the firmware update utility to update firmware stored in the firmware storage device(s) that was unlocked with the firmware update image and, subsequent to the operating system engine updating the firmware stored in the at least one firmware storage device that was unlocked, performs a firmware storage device lock operation to lock the firmware storage device(s).

Abstract: An Information Handling System (IHS) includes multiple hardware devices, and a baseboard Management Controller (BMC) in communication with the plurality of hardware devices. The BMC includes executable instructions for beginning execution of a first BMC firmware stack, and during execution of the first BMC firmware stack, halt execution of the first BMC firmware stack, and begin execution of a second BMC firmware stack. At least a portion of the executable instructions used to generate the first BMC firmware stack are different than the executable instructions used to generate the second BMC firmware stack.

Abstract: The invention relates to substituted nucleoside analogues of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: A Computing environment is described to enable an information handling system (IHS) to receive a public encryption key from another IHS; and decrypt with a public encryption key one or more encrypted symmetric encryption keys, encrypted via a private encryption key, to obtain one or more symmetric encryption keys respectively associated with one or more memory address ranges. The IHS may physically receive a memory device that was utilized by the other IHS to store information in an encrypted fashion. The IHS may further decrypt, with a first encryption key of the one or more symmetric encryption keys associated with a first address range of the one or more address ranges, first encrypted data stored by the at least one non-volatile memory medium to obtain first data.

Abstract: An Information Handling System (IHS) includes multiple hardware devices, and a baseboard Management Controller (BMC) in communication with the plurality of hardware devices. The BMC includes executable instructions for beginning execution of a first BMC firmware stack, and during execution of the first BMC firmware stack, halt execution of the first BMC firmware stack, and begin execution of a second BMC firmware stack. At least a portion of the executable instructions used to generate the first BMC firmware stack are different than the executable instructions used to generate the second BMC firmware stack.

Abstract: A firmware update system includes firmware storage device(s), an operating system engine coupled to the firmware storage device(s), and a remote access controller device coupled to the firmware storage device(s) and the operating system engine. The remote access controller device receives a single out-of-band firmware update command and, in response, performs a firmware storage device unlock operation to unlock the firmware storage device(s), transmits a firmware update package including a firmware update utility and a firmware update image to the operating system engine to cause the operating system engine to utilize the firmware update utility to update firmware stored in the firmware storage device(s) that was unlocked with the firmware update image and, subsequent to the operating system engine updating the firmware stored in the at least one firmware storage device that was unlocked, performs a firmware storage device lock operation to lock the firmware storage device(s).

Abstract: A method of detecting flame state of a combustor of a turbine engine. The method includes determining at least one of a first derivative and a second derivative of a compressor discharge pressure of a compressor of the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine exhaust gas temperature of the exhaust gases output by the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine shaft/rotor speed of the turbine engine; determining at least one of a first derivative and a second derivative of combustor dynamic pressure monitoring; and determining a flame state of a combustor of the turbine engine based on the combustor dynamic pressure monitoring, the determined derivatives of the combustion dynamics, compressor discharge pressure, gas turbine shaft/rotor speed, and gas turbine exhaust gas temperature of the exhaust gases.

Abstract: An artificial intelligence (“AI”) based system is disclosed for associating low-level user content, such as documents, email messages, and calendar invites, with high-level user activities using topics as an abstraction. The associations can enable a computing system to provide, among other things, activity-specific views that present a specific selection of low-level user content that is most relevant to a user at a particular point in time. The activity-specific views present the right information to users at the right time based on a context of a user and a user's past activities.

Abstract: The invention relates to substituted nucleoside analogues of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: A method of detecting flame state of a combustor of a turbine engine. The method includes determining at least one of a first derivative and a second derivative of a compressor discharge pressure of a compressor of the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine exhaust gas temperature of the exhaust gases output by the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine shaft/rotor speed of the turbine engine; determining at least one of a first derivative and a second derivative of combustor dynamic pressure monitoring; and determining a flame state of a combustor of the turbine engine based on the combustor dynamic pressure monitoring, the determined derivatives of the combustion dynamics, compressor discharge pressure, gas turbine shaft/rotor speed, and gas turbine exhaust gas temperature of the exhaust gases.

Abstract: An artificial intelligence (“AI”)-based system is disclosed for utilizing a schema to auto-generate an application for a specific context. An AI engine selects an activity schema associated with an activity. The schema identifies data sources for obtaining activity-specific content for the activity and can be selected based upon topics associated with the activity. The AI engine also selects a view definition that defines an arrangement of an activity-specific user interface (“UI”) for presenting relevant activity-specific content obtained from the data sources identified by the schema. An application is then generated using the schema and the view definition. The application can generate the activity-specific UI for presenting the relevant activity-specific content.

Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Abstract: An artificial intelligence (“AI”)-based system is disclosed for presenting activity-specific views of relevant activity-specific content. An AI engine selects activity-specific content relating to a multitude of activities. The selected activities can have associated relevance scores exceeding a predefined threshold value. The selected activity-specific content can be used to render user interface (“UI”) elements in a UI for the activities. The UI elements present an activity-specific view of the activity-specific content relating to each activity.

Abstract: An information handling system may include an information handling resource, and a management controller configured to provide out-of-band management of the information handling system and coupled to the information handling resource via a communications bus. The management controller may be configured to cause the information handling resource to update a firmware thereof by transmitting a plurality of datagrams to the information handling resource via the communications bus, wherein the plurality of datagrams includes: a pilot datagram comprising a first header that includes information regarding an update payload, wherein the pilot datagram is configured to trigger an update handler of the information handling resource; and one or more subsequent datagrams comprising second headers and respective portions of the update payload, wherein the update handler is configured to update the firmware based on the update payload.

Abstract: A support information provisioning system a support device, an external device; and a customer device. The customer device includes an external connector and a remote access controller device that is coupled to the external connector. In situations where the customer device is experiencing at least one customer device issue that prevents the customer device from provisioning support information related to the operation of the customer device, the remote access controller device operates to detect that the external device has been connected to the external connector and, in response, automatically cause new support information about that customer device to be generated. When the external device is subsequently connected to the support device, it may then provide that new support information to the support device for analysis.

Abstract: In one or more embodiments, an information handling system (IHS) may receive a public encryption key from another IHS; and decrypt with a public encryption key the one or more encrypted symmetric encryption keys, encrypted via a private encryption key, to obtain one or more symmetric encryption keys respectively associated with one or more memory address ranges. The IHS may physically receive a memory device, which includes at least one volatile memory medium and at least one non-volatile memory medium, that was utilized by the other IHS to store information in an encrypted fashion. The IHS may further decrypt with a first encryption key of the one or more symmetric encryption keys associated with a first address range of the one or more address ranges, by the information handling system, first encrypted data stored by the at least one non-volatile memory medium to obtain first data.

Abstract: Methods, systems, and computer programs encoded on computer storage medium, for identifying a first user access event that failed authentication at the first computing device; creating a transaction block of a distributed ledger based on the first user access event; determining that data indicating the first user access event is not included by the distributed ledger, and in response, adding the transaction block to a temporal vector space of the distributed ledger; sharing, to each other computing device of the local network, the transaction block, wherein each of the others computing devices of the local network updates a local copy of the distributed ledger to include the transaction block in the temporal vector space.