Patents by Inventor Prabhudas Bodhuri

Prabhudas Bodhuri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR SYNTHESIZING ANHYDROUS LACTIC ACID
    Publication number: 20230348352
    Abstract: A method of synthesizing anhydrous lactic acid is provided by reacting a compound of formula (Ia): with an acid compound of formula HnX in a first solvent to produce a reaction mixture comprising a compound of formula (Ib) and a lactic acid compound of formula (I) in solution with the first solvent and/or water. n is an integer other than 0, x is 0, or an integer other than 0, M is an alkali metal or alkaline earth metal and X is the conjugate base of the acid compound of formula HnX. The resulting reaction mixture is filtered to produce a filtrate containing lactic acid in solution. The filtrate is crystalized from a second solvent to produce anhydrous lactic acid.
    Type: Application
    Filed: May 3, 2021
    Publication date: November 2, 2023
    Inventors: Prabhudas BODHURI, Hem Raj KHATRI, Nipun DAVAR
  • IAP ANTAGONIST COMPOUNDS AND INTERMEDIATES AND METHODS FOR SYNTHESIZING THE SAME
    Publication number: 20230183234
    Abstract: A compound of formula (XXIII) and methods for preparation thereof are provided (XXIII).
    Type: Application
    Filed: May 3, 2021
    Publication date: June 15, 2023
    Inventors: Prabhudas BODHURI, Hem Raj KHATRI, Nipun DAVAR, Ian SCOTT
  • Processes for the preparation of Tezacaftor and intermediates thereof
    Patent number: 10875846
    Abstract: The present invention provides processes for the preparation of Tezacaftor, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the preparation of a compound of Formula (3), and its conversion to Tezacaftor (1).
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: December 29, 2020
    Assignee: Apotex Inc.
    Inventors: Michael R. Emmett, Prabhudas Bodhuri, Yajun Zhao, Eduardo Gustavo Cammisa, Stuart P. Green
  • Process for the preparation of acalabrutinib
    Patent number: 10800787
    Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: October 13, 2020
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Boris Gorin, Melanie R. A. Green, Gamini Weeratunga
  • Processes for the Preparation of Tezacaftor and Intermediates Thereof
    Publication number: 20200223832
    Abstract: The present invention provides processes for the preparation of Tezacaftor, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the preparation of a compound of Formula (3), and its conversion to Tezacaftor (1).
    Type: Application
    Filed: January 13, 2020
    Publication date: July 16, 2020
    Inventors: Michael R. Emmett, Prabhudas Bodhuri, Yajun Zhao, Eduardo Gustavo Cammisa, Stuart P. Green
  • Processes for the Preparation of Veliparib and Intermediates Thereof
    Publication number: 20200172514
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Application
    Filed: February 6, 2020
    Publication date: June 4, 2020
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Acalabrutinib and Intermediates Thereof
    Publication number: 20200048264
    Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
    Type: Application
    Filed: April 17, 2018
    Publication date: February 13, 2020
    Inventors: Prabhudas Bodhuri, Boris Gorin, Melanie R. A. Green, Gamini Weeratunga
  • Processes for the preparation of Veliparib and intermediates thereof
    Patent number: 10556887
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: February 11, 2020
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Dasotraline and Intermediates Thereof
    Publication number: 20190390235
    Abstract: The present invention provides processes for the preparation of Dasotraline, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the enzymatic transamination of a compound of Formula (2) to afford Dasotraline.
    Type: Application
    Filed: June 12, 2019
    Publication date: December 26, 2019
    Inventors: Fabio E. S. Souza, Prabhudas Bodhuri, Eduardo Gustavo Cammisa, Gamini Weeratunga, Allan W. Rey
  • Processes for the preparation of apalutamide and intermediates thereof
    Patent number: 10513504
    Abstract: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: December 24, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Alfredo Paul Ceccarelli, Michael R. Emmett, Avedis Karadeolian, Fabio E. S. Souza, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of 3-(4-Halobutyl)-5-Cyanoindole
    Publication number: 20190330150
    Abstract: The present invention provides continuous flow processes for the preparation of the compound of Formula (1), an intermediate in the preparation of Vilazodone.
    Type: Application
    Filed: April 23, 2019
    Publication date: October 31, 2019
    Inventors: Gamini Weeratunga, Avedis Karadeolian, Prabhudas Bodhuri, Dineshkumar N. Patel, Boris Gorin
  • Processes for the Preparation of Apalutamide and Intermediates Thereof
    Publication number: 20190276424
    Abstract: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
    Type: Application
    Filed: March 6, 2019
    Publication date: September 12, 2019
    Inventors: Prabhudas Bodhuri, Alfredo Paul Ceccarelli, Michael R. Emmett, Avedis Karadeolian, Fabio E. S. Souza, Gamini Weeratunga, Boris Gorin
  • Processes for the preparation of lesinurad and intermediates thereof
    Patent number: 10351537
    Abstract: The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1).
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: July 16, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Melanie R. A. Green, Avedis Karadeolian, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Dasotraline and Intermediates Thereof
    Publication number: 20190194122
    Abstract: The present invention provides processes for the preparation of Dasotraline (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (2), or a salt thereof, and its deprotection to afford Dasotraline (1).
    Type: Application
    Filed: December 18, 2018
    Publication date: June 27, 2019
    Inventors: Prabhudas Bodhuri, Eduardo Gustavo Cammisa, Melanie R.A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the preparation of edoxaban and intermediates thereof
    Patent number: 10301322
    Abstract: The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate compounds and/or salts of the Formulae (3), (4), (6-A), (7-A), (8-A), (9-A) and (10-AS) are provided.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 28, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Avedis Karadeolian, Eduardo Gustavo Cammisa, Stuart P. Green, Melanie R. A. Green, Alfredo Paul Ceccarelli
  • Processes for the Preparation of Veliparib and Intermediates Thereof
    Publication number: 20190119257
    Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).
    Type: Application
    Filed: October 23, 2018
    Publication date: April 25, 2019
    Inventors: Prabhudas Bodhuri, Kaarina K. Milnes, Melanie R. A. Green, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Lesinurad and Intermediates Thereof
    Publication number: 20180258057
    Abstract: The present invention provides processes for the preparation of Lesinurad (1), as well as intermediates useful in the preparation thereof. In particular, the processes of the invention utilize novel intermediate compounds of Formulas (3) and (11), which provide improvements over the known processes for the preparation of Lesinurad (1).
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: Prabhudas Bodhuri, Melanie R. A. Green, Avedis Karadeolian, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Edoxaban and Intermediates Thereof
    Publication number: 20180179226
    Abstract: The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate compounds and/or salts of the Formulae (3), (4), (6-A), (7-A), (8-A), (9-A) and (10-AS) are provided.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 28, 2018
    Inventors: Prabhudas Bodhuri, Avedis Karadeolian, Eduardo Gustavo Cammisa, Stuart P. Green, Melanie R. A. Green, Alfredo Paul Ceccarelli
  • Solid forms of tofacitinib salts
    Patent number: 9260438
    Abstract: Solid and crystalline forms of tofacitinib hydrochloride and tofacitinib hydrobromide, processes for the preparation thereof and processes for the use thereof in preparing tofacitinib citrate are provided.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: February 16, 2016
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Stuart P. Green, Fan Wang, Cameron L. McPhail, Eduardo Gustavo Cammisa, Avedis Karadeolian
  • SOLID FORMS OF TOFACITINIB SALTS
    Publication number: 20150225406
    Abstract: Solid and crystalline forms of tofacitinib hydrochloride and tofacitinib hydrobromide, processes for the preparation thereof and processes for the use thereof in preparing tofacitinib citrate are provided.
    Type: Application
    Filed: February 6, 2015
    Publication date: August 13, 2015
    Inventors: Prabhudas Bodhuri, Stuart P. Green, Fan Wang, Cameron L. McPhail, Eduardo Gustavo Cammisa, Avedis Karadeolian