Abstract: This invention relates to a pharmaceutical composition comprising 5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine as the active pharmaceutical ingredient, and therapeutic uses of the pharmaceutical formulation. In particular, the invention is directed to tablets comprising the pharmaceutical composition, methods of preparing the tablets, and therapeutic uses thereof.

Abstract: Rate limiting of cloud account change events and state management is described herein. One embodiment includes instructions to process each of a first stream of change events received from a cloud provider and associated with any assets of a particular public cloud account, determine that the first stream of change events exceeds a rate threshold, discard each of a second stream of change events received from the public cloud provider and associated with any assets of the particular public cloud account, query the cloud provider to perform a collection on all the assets of the particular public cloud account after a particular delay period, and process each of a third stream of change events received from the cloud provider and associated with any assets of the particular public cloud account responsive to a completion of the collection.

Abstract: Systems and methods are described for linking Kubernetes resources with underlying infrastructure. An agent running in a Kubernetes cluster can collect data about the cluster. The agent can add universal identifiers (“UIDs”) corresponding to specific characteristics of the Kubernetes cluster. The agent can send the data with the UIDs to a backend service. The backend service can identify a cluster on a host platform that corresponds to the Kubernetes cluster based on the UIDs. The backend service can then link components of the Kubernetes cluster to host machines in the host platform that they are running on. Using the links, a graph model can be displayed in a graphical user interface. The graph model can visually illustrate how the components in the Kubernetes cluster and the host cluster connect to each other.

Abstract: Rate limiting of cloud account change events and state management is described herein. One embodiment includes instructions to process each of a first stream of change events received from a cloud provider and associated with any assets of a particular public cloud account, determine that the first stream of change events exceeds a rate threshold, discard each of a second stream of change events received from the public cloud provider and associated with any assets of the particular public cloud account, query the cloud provider to perform a collection on all the assets of the particular public cloud account after a particular delay period, and process each of a third stream of change events received from the cloud provider and associated with any assets of the particular public cloud account responsive to a completion of the collection.

Abstract: A content publisher can use a publisher tool to tag various content elements, which enables a user viewing content from the publisher to view related advertising. In at least some embodiments, the tool is a toolbar that the publisher can use to tag content elements such as images and text, whereby the toolbar can recommend related items to be linked to those content elements. The items can be associated with an entity, such as an advertiser or electronic retailer, that will provide some level of compensation to the publisher in return for the linking. Such an approach enables the publisher to monetize the content in a way that is minimally intrusive for the end user.

Abstract: A method and system for transit characteristic prediction. In one embodiment, a method may include determining respective transit latencies from a source location to a number of destination locations, and grouping the destination locations according to a similarity criterion into a number of subsets corresponding to respective geographical regions, where transit characteristics of locations grouped into a geographical region may each satisfy the similarity criterion. The method may further include determining a respective distribution associated with each of the geographical regions, where a given respective distribution correlates a given transit characteristic from the source location to a given geographical region with a respective surety factor, where the respective surety factor includes a cumulative probability that the given transit characteristic will be achieved.

Abstract: A content publisher can use a publisher tool to tag various content elements, which enables a user viewing content from the publisher to view related advertising. In at least some embodiments, the tool is a toolbar that the publisher can use to tag content elements such as images and text, whereby the toolbar can recommend related items to be linked to those content elements. The items can be associated with an entity, such as an advertiser or electronic retailer, that will provide some level of compensation to the publisher in return for the linking. Such an approach enables the publisher to monetize the content in a way that is minimally intrusive for the end user.

Abstract: A content publisher can use a publisher tool to tag various content elements, which enables a user viewing content from the publisher to view related advertising. In at least some embodiments, the tool is a toolbar that the publisher can use to tag content elements such as images and text, whereby the toolbar can recommend related items to be linked to those content elements. The items can be associated with an entity, such as an advertiser or electronic retailer, that will provide some level of compensation to the publisher in return for the linking. Such an approach enables the publisher to monetize the content in a way that is minimally intrusive for the end user.

Abstract: A content publisher can use a publisher tool to tag various content elements, which enables a user viewing content from the publisher to view related advertising. In at least some embodiments, the tool is a toolbar that the publisher can use to tag content elements such as images and text, whereby the toolbar can recommend related items to be linked to those content elements. The items can be associated with an entity, such as an advertiser or electronic retailer, that will provide some level of compensation to the publisher in return for the linking. Such an approach enables the publisher to monetize the content in a way that is minimally intrusive for the end user.

Abstract: Various embodiments of a system and method for constraint-based reduction of a solution space for vehicle routing are described. Embodiments may include a system configured to identify sets of redundant routes within a solution space. For each given set of redundant routes, the system may utilize one or more constraints associated with conveying shipments on routes of the given set in order to eliminate one or more routes of that set from consideration. For each of multiple routes of the given set that have not been eliminated from consideration, the system may determine a respective cost associated with utilizing that route. The system may also, in response to determining that the cost associated with a particular route that has not been eliminated from consideration is less than the cost associated with other routes that have not been eliminated from consideration, add the particular route to a reduced solution space.

Abstract: In various embodiments, approaches for the placement of inbound inventory in a materials handling facility are described. A product identifier is input from inbound inventory into a computer system, where the inbound inventory is to be stocked in a materials handling facility. At least one available inventory location is identified in the computer system that presents a lowest cost for storage of the inbound inventory in the materials handling facility. The inbound inventory is stocked in the at least one available inventory location contemporaneously with the determination of the at least one available inventory location in the computer system that presents the lowest cost for storage of the inbound inventory in the materials handling facility.

Abstract: A method and system for transit characteristic prediction. In one embodiment, a method may include determining respective transit latencies from a source location to a number of destination locations, and grouping the destination locations according to a similarity criterion into a number of subsets corresponding to respective geographical regions, where transit characteristics of locations grouped into a geographical region may each satisfy the similarity criterion. The method may further include determining a respective distribution associated with each of the geographical regions, where a given respective distribution correlates a given transit characteristic from the source location to a given geographical region with a respective surety factor, where the respective surety factor includes a cumulative probability that the given transit characteristic will be achieved.