Abstract: The present invention relates to a disintegrant free pharmaceutical composition comprising apremilast or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. Particularly the present invention relates to disintegrant free immediate release dosage form comprising apremilast or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. It further relates to process of preparing such composition and its use in psoriatic arthritis and psoriasis.

Abstract: The present invention relates to a disintegrant free pharmaceutical composition comprising apremilast or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. Particularly the present invention relates to disintegrant free immediate release dosage form comprising apremilast or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. It further relates to process of preparing such composition and its use in psoriatic arthritis and psoriasis.

Abstract: An event monitoring, identifying and predicting system comprises at least one database comprising an incoming sensor data stream; a plurality of available data processing engines requiring engine-specific event identifying instruction sets; an abstraction engine configured to receive at least one engine-agnostic event identifying instruction set and convert the at least one engine-agnostic event identifying instruction set to an engine-specific event identifying instruction set suitable for a selected one of the plurality of available data processing engines; a user interface comprising a data processing engine selector by which a user can provide an engine-agnostic event identifying instruction set and select a available data processing engines; and a report generator configured to provide an output result of processing at least a portion of the incoming sensor data stream by the selected data processing engine according to the engine-specific event identifying instruction set.

Abstract: Embodiments relate to event monitoring, identifying and predicting system comprises at least one database comprising an incoming data stream; a plurality of available data processing engines, each of the plurality of available data processing engines requiring an engine-specific event identifying instruction set; an abstraction engine configured to receive at least one engine-agnostic event identifying instruction set and convert the at least one engine-agnostic event identifying instruction set to an engine-specific event identifying instruction set suitable for a selected one of the plurality of available data processing engines; and a user interface comprising a data processing engine selector by which a user can provide the at least one engine-agnostic event identifying instruction set and select the one of the plurality of available data processing engines, and a report generator configured to provide an output result of processing at least a portion of the incoming data stream from the database by the s

Abstract: Embodiments are directed to managing content over a network. A plurality of events that may be associated with event sources may be determined. Action information may be generated based on classification of events to action events, such that the events may correspond to a campaign for a merchant. Classifying the events may also include, determining an action type that may correspond to each event based in part on an event source that corresponds to the events. Performance information may be generated based on the action information. Comparison information may be generated based on at least other performance information that may correspond to other campaigns that may be associated with other merchants. Recommendation information may be generated based on the performance information and the comparison information. Report information may be generated for display to a user based on the performance information and the recommendation information.

Abstract: A consolidated electronic payment system operated by a retailer exclusively for its customers is disclosed. Otherwise independent and limited authentication and payment resources are consolidated within the unified system, facilitating broader access at retail checkout to several payment instruments. System functions are executed jointly by a customer-facing checkout facility and backend network resources comprising an authentication agent and a payment processor. Individual customers registered within the system are assigned a primary customer account, which is recorded within the network's data storage facility. Associated with these accounts are all available payment instruments and certain existing authentication accounts. For retail transactions, personal identification information and payment instructions submitted by the customer are transmitted to the network from checkout, with pertinent authentication and payment signals generated and transmitted back in response thereto.

Abstract: The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride monohydrate with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-AP), (b) reacting the 4-AP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80° C.

Abstract: The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride (NPP) with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-ANPP), (b) reacting the 4-ANPP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80° C.

Abstract: A process for the preparation of n-heneicosane is disclosed. The process comprises (a) reacting 2,4-alkaneanedione with 1-bromooctadecane in absolute ethanol in the presence of 18-crown-6 as catalyst to produce 2-heneicosanone; and (b) reducing said 2-heneicosanone using hydrazine hydrate and potassium hydroxide in ethylene glycol to obtain n-heneicosane.

Abstract: Pharmaceutical compositions comprising eszopiclone, including its pharmaceutically acceptable salts, hydrates, clathrates, solvates, polymorphs, and mixtures thereof. The invention also relates to processes for preparing the compositions and their methods of use.

Abstract: A system and the method for transport of microscopic objects/particles involving the use of laser source operatively connected to a microscope objective which is adapted to generate optical focal spots on said particle(s) with asymmetric intensity profile in transverse plane followed by varying the said asymmetry of the gradient optical forces on the micron sized object/particles to thereby transport the microscopic object(s). The system and the method can be used to transport microscopic objects including i) transportation of cells and intra-cellular organelles, ii) acceleration of microscopic objects along any direction in a plane transverse to the direction of propagation of laser beam, iii) optical channeling of objects through a micro-capillary from one micro-well to another and transfer to another channel after desired processing, iv) sorting of microscopic objects, v) optical control of micro-machines, micro-fluidic devices etc.